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Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061

The Journal of pharmacology and experimental therapeutics, 2018-05, Vol.365 (2), p.301-313

2018

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Sodium Nitrite-Mediated Killing of the Major Cystic Fibrosis Pathogens Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia under Anaerobic Planktonic and Biofilm Conditions

Antimicrobial Agents and Chemotherapy, 2010-11, Vol.54 (11), p.4671-4677

2010

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Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor

The Journal of pharmacology and experimental therapeutics, 2004-05, Vol.309 (2), p.634-640

2004

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Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction

Respiratory research, 2010-06, Vol.11 (1), p.81-81, Article 81

2010

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A caspase inhibitor, IDN‐6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia

Liver transplantation, 2007-03, Vol.13 (3), p.361-366

2007

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Modes of Cell Death in Rat Liver after Monocrotaline Exposure

Toxicological sciences, 2004-01, Vol.77 (1), p.172-182

2004

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Reactions of Peroxynitrite with γ-Tocopherol

Chemical research in toxicology, 1997-04, Vol.10 (4), p.401-407

1997

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Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury

The Journal of pharmacology and experimental therapeutics, 2001-05, Vol.297 (2), p.811

2001

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A 26-Week Toxicity Assessment of AIR001 (Sodium Nitrite) by Inhalation Exposure in Rats and by Intravenous Administration in Dogs

International journal of toxicology, 2014-05, Vol.33 (3), p.162-174

2014

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Diethyldithiocarbamate Enhances Production of Nitric Oxide and TNF-α by Lipopolysaccharide-Stimulated Rat Kupffer Cells

Toxicological sciences, 2000-05, Vol.55 (1), p.206-214

2000

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874 IDN-6556, the first anti-apoptotic caspase inhibitor in clinical trials: tissue distribution and pharmacokinetics

Hepatology (Baltimore, Md.), 2003, Vol.38, p.580-581

2003

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Role of Nitric Oxide and Peroxynitrite in Bile Salt-Induced Apoptosis: Relevance to Colon Carcinogenesis

Nutrition and cancer, 1999-01, Vol.35 (2), p.180-188

1999

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871 IDN-6556, the first anti-apoptotic caspase inhibitor: preclinical efficacy and safety

Hepatology (Baltimore, Md.), 2003, Vol.38, p.579-579

2003

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[49] Products from reaction of peroxynitrite with γ-tocopherol

Methods in Enzymology, 1999, Vol.301, p.483-490

1999

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Activated caspase 3 and tunel-positive cells in livers of patients with decompensated alcoholic hepatitis

Gastroenterology (New York, N.Y. 1943), 2000-04, Vol.118 (4), p.A975-A975

2000

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Reduction of thyroid hormone may participate in the modulation of cytochromes P450 2C11 and 3A2 by retinol

Life sciences (1973), 1998, Vol.63 (25), p.PL367-PL372

1998

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1,2-Dichlorobenzene-lnduced Lipid Peroxidation in Male Fischer 344 Rats is Kupffer Cell Dependent

Toxicological sciences, 1998-12, Vol.46 (2), p.376-385

1998

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Mechanisms of polyhalogenated biphenyl enhancement of endotoxicity

Hoglen, Niel Christian

1993

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3,3′,4,4′-Tetrabromobiphenyl sensitizes rats to the hepatotoxic effects of endotoxin by a mechanism that involves more than tumor necrosis factor

Hepatology (Baltimore, Md.), 1991-12, Vol.14 (6), p.1201-1208

1991

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3,3′,4,4′‐Tetrabromobiphenyl sensitizes rats to the hepatotoxic effects of endotoxin by a mechanism that involves more than tumor necrosis factor

Hepatology (Baltimore, Md.), 1991-12, Vol.14 (6), p.1201-1208

1991

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Modulation of Kupffer cell and peripheral blood monocyte activity by in vivo treatment of rats with all-trans-retinol

Liver (Copenhagen), 1997-06, Vol.17 (3), p.157-165

1997

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Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061

Sodium Nitrite-Mediated Killing of the Major Cystic Fibrosis Pathogens Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia under Anaerobic Planktonic and Biofilm Conditions

Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor

Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction

A caspase inhibitor, IDN‐6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia

Modes of Cell Death in Rat Liver after Monocrotaline Exposure

Reactions of Peroxynitrite with γ-Tocopherol

Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury

A 26-Week Toxicity Assessment of AIR001 (Sodium Nitrite) by Inhalation Exposure in Rats and by Intravenous Administration in Dogs

First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease

Diethyldithiocarbamate Enhances Production of Nitric Oxide and TNF-α by Lipopolysaccharide-Stimulated Rat Kupffer Cells

874 IDN-6556, the first anti-apoptotic caspase inhibitor in clinical trials: tissue distribution and pharmacokinetics

Role of Nitric Oxide and Peroxynitrite in Bile Salt-Induced Apoptosis: Relevance to Colon Carcinogenesis

871 IDN-6556, the first anti-apoptotic caspase inhibitor: preclinical efficacy and safety

[49] Products from reaction of peroxynitrite with γ-tocopherol

Activated caspase 3 and tunel-positive cells in livers of patients with decompensated alcoholic hepatitis

Reduction of thyroid hormone may participate in the modulation of cytochromes P450 2C11 and 3A2 by retinol

1,2-Dichlorobenzene-lnduced Lipid Peroxidation in Male Fischer 344 Rats is Kupffer Cell Dependent

Mechanisms of polyhalogenated biphenyl enhancement of endotoxicity

3,3′,4,4′-Tetrabromobiphenyl sensitizes rats to the hepatotoxic effects of endotoxin by a mechanism that involves more than tumor necrosis factor

3,3′,4,4′‐Tetrabromobiphenyl sensitizes rats to the hepatotoxic effects of endotoxin by a mechanism that involves more than tumor necrosis factor

Modulation of Kupffer cell and peripheral blood monocyte activity by in vivo treatment of rats with all-trans-retinol

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