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In Vivo Inhibition of RIPK2 Kinase Alleviates Inflammatory Disease

The Journal of biological chemistry, 2014-10, Vol.289 (43), p.29651-29664

2014

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Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells

JBMR plus, 2019-11, Vol.3 (11), p.e10230-n/a

2019

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Abstract 3298: Unlocking the potential of OPM-383: A novel LRRK2 inhibitor in cancer therapy

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.3298-3298

2024

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Abstract 1957: OPM-116, a highly potent and specific PI3Kγ inhibitor to enhance antitumor immunity

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.1957-1957

2024

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Development of small macrocyclic kinase inhibitors

Future medicinal chemistry, 2022-03, Vol.14 (6), p.389-391

2022

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Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin

FEBS letters, 1996-11, Vol.397 (2), p.201-206

1996

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Inhibiting Endothelial Cell Function in Normal and Tumor Angiogenesis Using BMP Type I Receptor Macrocyclic Kinase Inhibitors

Cancers, 2021-06, Vol.13 (12), p.2951

2021

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Abstract 5370: New oncology target identification and validation platform combining artificial intelligence and preclinical pharmacology

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.5370-5370

2023

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Phase 0/1 of positron emission tomography (PET) imaging agent [18F]-ODS2004436 as a marker of EGFR mutation in patients with non-small cell lung cancer (NSCLC)

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.e24184-e24184

2018

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Abstract 1875A: Preclinical proof of concept for the first Nanocyclix TKI-PET radiotracer targeting activated EGFR positive lung tumors

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1875-1875A

2017

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Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors

Journal of medicinal chemistry, 1992-09, Vol.35 (19), p.3448-3462

1992

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Abstract 740: Oncodesign translational drug discovery process

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.740-740

2010

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The binding site of neuropeptide vasopressin V1a receptor. Evidence for a major localization within transmembrane regions

The Journal of biological chemistry, 1995-10, Vol.270 (43), p.25771-25777

1995

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Three-dimensional models of neurotransmitter G-binding protein-coupled receptors

Molecular pharmacology, 1991-07, Vol.40 (1), p.8

1991

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Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor

The EMBO journal, 1995-05, Vol.14 (10), p.2176-2182

1995

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Solution structure of salmon calcitonin

Biopolymers, 1991-02, Vol.31 (2), p.233-241

1991

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REALISIS: A Medicinal Chemistry-Oriented Reagent Selection, Library Design, and Profiling Platform

Journal of Chemical Information and Computer Sciences, 2004-11, Vol.44 (6), p.2199-2206

2004

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The Binding Site of Neuropeptide Vasopressin V1a Receptor

The Journal of biological chemistry, 1995-10, Vol.270 (43), p.25771-25777

1995

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Structure of neuropeptide Y dimer in solution

European journal of biochemistry, 1992-05, Vol.205 (3), p.1099-1106

1992

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α-Hydroxytropolones: A New Class of Potent Inhibitors of Inositol Monophosphatase and Other Bimetallic Enzymes

Journal of the American Chemical Society, 1997-04, Vol.119 (14), p.3201-3204

1997

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Re-evaluation of bacteriorhodopsin as a model for G protein-coupled receptors

Trends in pharmacological sciences (Regular ed.), 1994, Vol.15 (1), p.7-9

1994

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This is not a G protein-coupled receptor

Trends in Pharmacological Sciences, 1993, Vol.14 (1), p.7-12

1993

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Inhibition of myo-inositol monophosphatase isoforms by aromatic phosphonates

Bioorganic & medicinal chemistry, 1998-10, Vol.6 (10), p.1865-1874

1998

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Activation of neurotensin receptors and purinoceptors in human colonic adenocarcinoma cells detected with the microphysiometer

Biochemical pharmacology, 1997-10, Vol.54 (7), p.825-832

1997

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Modelling of the binding site of the human m1 muscarinic receptor: experimental validation and refinement

Journal of computer-aided molecular design, 1997-07, Vol.11 (4), p.317-332

1997

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In Vivo Inhibition of RIPK2 Kinase Alleviates Inflammatory Disease

Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells

Abstract 3298: Unlocking the potential of OPM-383: A novel LRRK2 inhibitor in cancer therapy

Abstract 1957: OPM-116, a highly potent and specific PI3Kγ inhibitor to enhance antitumor immunity

Development of small macrocyclic kinase inhibitors

Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin

Inhibiting Endothelial Cell Function in Normal and Tumor Angiogenesis Using BMP Type I Receptor Macrocyclic Kinase Inhibitors

Abstract 5370: New oncology target identification and validation platform combining artificial intelligence and preclinical pharmacology

Phase 0/1 of positron emission tomography (PET) imaging agent [18F]-ODS2004436 as a marker of EGFR mutation in patients with non-small cell lung cancer (NSCLC)

Abstract 1875A: Preclinical proof of concept for the first Nanocyclix TKI-PET radiotracer targeting activated EGFR positive lung tumors

Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors

Abstract 740: Oncodesign translational drug discovery process

The binding site of neuropeptide vasopressin V1a receptor. Evidence for a major localization within transmembrane regions

Three-dimensional models of neurotransmitter G-binding protein-coupled receptors

Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptor

Solution structure of salmon calcitonin

REALISIS: A Medicinal Chemistry-Oriented Reagent Selection, Library Design, and Profiling Platform

The Binding Site of Neuropeptide Vasopressin V1a Receptor

Structure of neuropeptide Y dimer in solution

α-Hydroxytropolones: A New Class of Potent Inhibitors of Inositol Monophosphatase and Other Bimetallic Enzymes

Re-evaluation of bacteriorhodopsin as a model for G protein-coupled receptors

This is not a G protein-coupled receptor

Inhibition of myo-inositol monophosphatase isoforms by aromatic phosphonates

Activation of neurotensin receptors and purinoceptors in human colonic adenocarcinoma cells detected with the microphysiometer

Modelling of the binding site of the human m1 muscarinic receptor: experimental validation and refinement

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