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Antibacterial Discovery: 21st Century Challenges

Antibiotics (Basel), 2020-04, Vol.9 (5), p.213

Hoffman, Paul S

2020

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Germination and Amplification of Anthrax Spores by Soil-Dwelling Amoebas

Applied and Environmental Microbiology, 2012-11, Vol.78 (22), p.8075-8081

2012

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Antiparasitic Drug Nitazoxanide Inhibits the Pyruvate Oxidoreductases of Helicobacter pylori, Selected Anaerobic Bacteria and Parasites, and Campylobacter jejuni

Antimicrobial Agents and Chemotherapy, 2007-03, Vol.51 (3), p.868-876

2007

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Response to Metronidazole and Oxidative Stress Is Mediated through Homeostatic Regulator HsrA (HP1043) in Helicobacter pylori

Journal of Bacteriology, 2014-02, Vol.196 (4), p.729-739

2014

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New functions of pirin proteins and a 2‐ketoglutarate: Ferredoxin oxidoreductase ortholog in Bacteroides fragilis metabolism and their impact on antimicrobial susceptibility to metronidazole and amixicile

MicrobiologyOpen (Weinheim), 2024-08, Vol.13 (4), p.e1429-n/a

2024

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Amixicile targets anaerobic bacteria within the oral microbiome

Journal of oral biosciences, 2019-12, Vol.61 (4), p.226-235

2019

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Structure of RdxA – an oxygen‐insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori

The FEBS journal, 2012-12, Vol.279 (23), p.4306-4317

2012

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Vancomycin Treatment's Association with Delayed Intestinal Tissue Injury, Clostridial Overgrowth, and Recurrence of Clostridium difficile Infection in Mice

Antimicrobial Agents and Chemotherapy, 2013-02, Vol.57 (2), p.689-696

2013

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The Helicobacter pylori Chemotaxis Receptor TlpB (HP0103) Is Required for pH Taxis and for Colonization of the Gastric Mucosa

Journal of Bacteriology, 2006-04, Vol.188 (7), p.2656-2665

2006

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Amixicile, a Novel Inhibitor of Pyruvate:Ferredoxin Oxidoreductase, Shows Efficacy against Clostridium difficile in a Mouse Infection Model

Antimicrobial Agents and Chemotherapy, 2012-08, Vol.56 (8), p.4103-4111

2012

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Amixicile depletes the ex vivo periodontal microbiome of anaerobic bacteria

Journal of oral biosciences, 2020-06, Vol.62 (2), p.195-204

2020

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Non-human Primate Macaca mulatta as an Animal Model for Testing Efficacy of Amixicile as a Targeted Anti-periodontitis Therapy

Frontiers in oral health, 2021-11, Vol.2, p.752929-752929

2021

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Disulfide Bond Oxidoreductase DsbA2 of Legionella pneumophila Exhibits Protein Disulfide Isomerase Activity

Journal of Bacteriology, 2013-04, Vol.195 (8), p.1825-1833

2013

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Mutations to Essential Orphan Response Regulator HP1043 of Helicobacter pylori Result in Growth-Stage Regulatory Defects

Infection and Immunity, 2013-05, Vol.81 (5), p.1439-1449

2013

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Cysteine Metabolism in Legionella pneumophila: Characterization of an l-Cystine-Utilizing Mutant

Applied and Environmental Microbiology, 2006-06, Vol.72 (6), p.3993-4000

2006

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Nitazoxanide Inhibits Biofilm Production and Hemagglutination by Enteroaggregative Escherichia coli Strains by Blocking Assembly of AafA Fimbriae

Antimicrobial Agents and Chemotherapy, 2010-04, Vol.54 (4), p.1526-1533

2010

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Compensatory Functions of Two Alkyl Hydroperoxide Reductases in the Oxidative Defense System of Legionella pneumophila

Journal of Bacteriology, 2006-09, Vol.188 (17), p.6235-6244

2006

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Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori

Antimicrobial Agents and Chemotherapy, 2002-07, Vol.46 (7), p.2116-2123

2002

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Essential Thioredoxin-Dependent Peroxiredoxin System from Helicobacter pylori: Genetic and Kinetic Characterization

Journal of Bacteriology, 2001-03, Vol.183 (6), p.1961-1973

2001

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Nitazoxanide Inhibits Biofilm Formation by Staphylococcus epidermidis by Blocking Accumulation on Surfaces

Antimicrobial Agents and Chemotherapy, 2010-07, Vol.54 (7), p.2767-2774

2010

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Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

Nature chemical biology, 2018-01, Vol.14 (1), p.94-101

2018

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Flavodoxin:Quinone Reductase (FqrB): a Redox Partner of Pyruvate:Ferredoxin Oxidoreductase That Reversibly Couples Pyruvate Oxidation to NADPH Production in Helicobacter pylori and Campylobacter jejuni

Journal of Bacteriology, 2007-07, Vol.189 (13), p.4764-4773

2007

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Intracellular Growth of Legionella pneumophila Gives Rise to a Differentiated Form Dissimilar to Stationary-Phase Forms

Infection and Immunity, 2002-11, Vol.70 (11), p.6273-6283

2002

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Infection of nonphagocytic host cells by legionella

Methods in molecular biology (Clifton, N.J.), 2013, Vol.954, p.463

2013

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Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane

Antimicrobial agents and chemotherapy, 2016-04, Vol.60 (4), p.2028-2038

2016

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Antibacterial Discovery: 21st Century Challenges

Germination and Amplification of Anthrax Spores by Soil-Dwelling Amoebas

Antiparasitic Drug Nitazoxanide Inhibits the Pyruvate Oxidoreductases of Helicobacter pylori, Selected Anaerobic Bacteria and Parasites, and Campylobacter jejuni

Response to Metronidazole and Oxidative Stress Is Mediated through Homeostatic Regulator HsrA (HP1043) in Helicobacter pylori

New functions of pirin proteins and a 2‐ketoglutarate: Ferredoxin oxidoreductase ortholog in Bacteroides fragilis metabolism and their impact on antimicrobial susceptibility to metronidazole and amixicile

Amixicile targets anaerobic bacteria within the oral microbiome

Structure of RdxA – an oxygen‐insensitive nitroreductase essential for metronidazole activation in Helicobacter pylori

Vancomycin Treatment's Association with Delayed Intestinal Tissue Injury, Clostridial Overgrowth, and Recurrence of Clostridium difficile Infection in Mice

The Helicobacter pylori Chemotaxis Receptor TlpB (HP0103) Is Required for pH Taxis and for Colonization of the Gastric Mucosa

Amixicile, a Novel Inhibitor of Pyruvate:Ferredoxin Oxidoreductase, Shows Efficacy against Clostridium difficile in a Mouse Infection Model

Amixicile depletes the ex vivo periodontal microbiome of anaerobic bacteria

Non-human Primate Macaca mulatta as an Animal Model for Testing Efficacy of Amixicile as a Targeted Anti-periodontitis Therapy

Disulfide Bond Oxidoreductase DsbA2 of Legionella pneumophila Exhibits Protein Disulfide Isomerase Activity

Mutations to Essential Orphan Response Regulator HP1043 of Helicobacter pylori Result in Growth-Stage Regulatory Defects

Cysteine Metabolism in Legionella pneumophila: Characterization of an l-Cystine-Utilizing Mutant

Nitazoxanide Inhibits Biofilm Production and Hemagglutination by Enteroaggregative Escherichia coli Strains by Blocking Assembly of AafA Fimbriae

Compensatory Functions of Two Alkyl Hydroperoxide Reductases in the Oxidative Defense System of Legionella pneumophila

Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori

Essential Thioredoxin-Dependent Peroxiredoxin System from Helicobacter pylori: Genetic and Kinetic Characterization

Nitazoxanide Inhibits Biofilm Formation by Staphylococcus epidermidis by Blocking Accumulation on Surfaces

Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

Flavodoxin:Quinone Reductase (FqrB): a Redox Partner of Pyruvate:Ferredoxin Oxidoreductase That Reversibly Couples Pyruvate Oxidation to NADPH Production in Helicobacter pylori and Campylobacter jejuni

Intracellular Growth of Legionella pneumophila Gives Rise to a Differentiated Form Dissimilar to Stationary-Phase Forms

Infection of nonphagocytic host cells by legionella

Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane

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