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Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

Drug and alcohol dependence, 2009-05, Vol.101 (3), p.158-168

2009

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The effect of quinidine, used as a probe for the involvement of P‐glycoprotein, on the intestinal absorption and pharmacodynamics of methadone

British journal of clinical pharmacology, 2004-05, Vol.57 (5), p.600-610

2004

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Intrasubject Variability in Intravenous and Oral Probes for Hepatic and First-Pass CYP3A Activity

Clinical pharmacokinetics, 2024-08, Vol.63 (8), p.1121-1135

2024

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Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate

Anesthesiology (Philadelphia), 2004-09, Vol.101 (3), p.729-737

2004

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Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate

Anesthesiology (Philadelphia), 2004-09, Vol.101 (3), p.738-743

2004

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Disposition of nasal, intravenous, and oral methadone in healthy volunteers

Clinical pharmacology and therapeutics, 2002-11, Vol.72 (5), p.536-545

2002

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Quinidine as a Probe for the Role of P-Glycoprotein in the Intestinal Absorption and Clinical Effects of Fentanyl

Journal of clinical pharmacology, 2004-03, Vol.44 (3), p.224-233

2004

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Simultaneous Measurement of In Vivo P-glycoprotein and Cytochrome P450 3A Activities

Journal of clinical pharmacology, 2006-11, Vol.46 (11), p.1313-1319

2006

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Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites

Clinical pharmacology and therapeutics, 2006-05, Vol.79 (5), p.461-479

2006

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Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

Clinical pharmacology and therapeutics, 2004-09, Vol.76 (3), p.250-269

2004

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Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport : Insights from Methadone Interactions with Ritonavir/Indinavir

Anesthesiology (Philadelphia), 2009-03, Vol.110 (3), p.660-672

2009

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Mechanism of Ritonavir Changes in Methadone Pharmacokinetics and Pharmacodynamics: II. Ritonavir Effects on CYP3A and P-Glycoprotein Activities

Clinical pharmacology and therapeutics, 2008-10, Vol.84 (4), p.506-512

2008

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Circumplex Model of Affect: A Measure of Pleasure and Arousal During Virtual Reality Distraction Analgesia

Games for health, 2016-06, Vol.5 (3), p.197-202

2016

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Contribution of Itraconazole Metabolites to Inhibition of CYP3A4 In Vivo

Clinical pharmacology and therapeutics, 2008-01, Vol.83 (1), p.77-85

2008

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Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A)

Anesthesiology (Philadelphia), 2012-02, Vol.116 (2), p.432-447

2012

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Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine

Clinical pharmacology and therapeutics, 2003-12, Vol.74 (6), p.543-554

2003

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Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: Noninvasive assessment by use of pupillary miosis

Clinical pharmacology and therapeutics, 2004-11, Vol.76 (5), p.452-466

2004

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Mechanism of Ritonavir Changes in Methadone Pharmacokinetics and Pharmacodynamics: I. Evidence Against CYP3A Mediation of Methadone Clearance

Clinical pharmacology and therapeutics, 2008-10, Vol.84 (4), p.497-505

2008

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KETAMINE AS A POSSIBLE MODERATOR OF HYPNOTIZABILITY: A Feasibility Study

International journal of clinical and experimental hypnosis, 2018-07, Vol.66 (3), p.298-307

2018

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Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics II: Hepatic and intestinal CYP2B6, CYP3A and transporter activities

Clinical pharmacology and therapeutics, 2012-03, Vol.91 (4), p.673-684

2012

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Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport

Anesthesiology (Philadelphia), 2009-03, Vol.110 (3), p.660-672

2009

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Sensitivity of Intravenous and Oral Alfentanil and Pupillary Miosis as Minimally Invasive and Noninvasive Probes for Hepatic and First-Pass CYP3A Activity

Journal of clinical pharmacology, 2005-10, Vol.45 (10), p.1187-1197

2005

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Evaluation of First-Pass Cytochrome P4503A (CYP3A) and P-Glycoprotein Activities Using Alfentanil and Fexofenadine in Combination

Journal of clinical pharmacology, 2005-01, Vol.45 (1), p.79-88

2005

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Disposition and miotic effects of oral alfentanil: A potential noninvasive probe for first-pass cytochrome P4503A activity

Clinical pharmacology and therapeutics, 2003-03, Vol.73 (3), p.199-208

2003

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Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-α-acetylmethadol : Importance of clinical Investigations to validate in vitro drug metabolism studies

Clinical pharmacokinetics, 2005-01, Vol.44 (7), p.731-751

2005

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Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

The effect of quinidine, used as a probe for the involvement of P‐glycoprotein, on the intestinal absorption and pharmacodynamics of methadone

Intrasubject Variability in Intravenous and Oral Probes for Hepatic and First-Pass CYP3A Activity

Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate

Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate

Disposition of nasal, intravenous, and oral methadone in healthy volunteers

Quinidine as a Probe for the Role of P-Glycoprotein in the Intestinal Absorption and Clinical Effects of Fentanyl

Simultaneous Measurement of In Vivo P-glycoprotein and Cytochrome P450 3A Activities

Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: Role of circulating active metabolites

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport : Insights from Methadone Interactions with Ritonavir/Indinavir

Mechanism of Ritonavir Changes in Methadone Pharmacokinetics and Pharmacodynamics: II. Ritonavir Effects on CYP3A and P-Glycoprotein Activities

Circumplex Model of Affect: A Measure of Pleasure and Arousal During Virtual Reality Distraction Analgesia

Contribution of Itraconazole Metabolites to Inhibition of CYP3A4 In Vivo

Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A)

Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine

Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: Noninvasive assessment by use of pupillary miosis

Mechanism of Ritonavir Changes in Methadone Pharmacokinetics and Pharmacodynamics: I. Evidence Against CYP3A Mediation of Methadone Clearance

KETAMINE AS A POSSIBLE MODERATOR OF HYPNOTIZABILITY: A Feasibility Study

Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics II: Hepatic and intestinal CYP2B6, CYP3A and transporter activities

Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport

Sensitivity of Intravenous and Oral Alfentanil and Pupillary Miosis as Minimally Invasive and Noninvasive Probes for Hepatic and First-Pass CYP3A Activity

Evaluation of First-Pass Cytochrome P4503A (CYP3A) and P-Glycoprotein Activities Using Alfentanil and Fexofenadine in Combination

Disposition and miotic effects of oral alfentanil: A potential noninvasive probe for first-pass cytochrome P4503A activity

Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-α-acetylmethadol : Importance of clinical Investigations to validate in vitro drug metabolism studies

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