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Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II

Scientific reports, 2019-08, Vol.9 (1), p.12220-12, Article 12220

2019

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Construction of an integrated database for hERG blocking small molecules

PloS one, 2018-07, Vol.13 (7), p.e0199348

2018

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The Genetics of Primary Biliary Cholangitis: A GWAS and Post-GWAS Update

Genes, 2023-02, Vol.14 (2), p.405

2023

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Clinical application of exome sequencing in undiagnosed genetic conditions

Journal of medical genetics, 2012-06, Vol.49 (6), p.353-361

2012

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Principal contribution of HLA-DQ alleles, DQB106:04 and DQB103:01, to disease resistance against primary biliary cholangitis in a Japanese population

Scientific reports, 2017-09, Vol.7 (1), p.11093-10, Article 11093

2017

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Analysis of whole Y-chromosome sequences reveals the Japanese population history in the Jomon period

Scientific reports, 2019-06, Vol.9 (1), p.8556-8, Article 8556

2019

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rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis

Scientific reports, 2021-02, Vol.11 (1), p.4557-4557, Article 4557

2021

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Identification of HLA-A02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing

Scientific reports, 2019-11, Vol.9 (1), p.16240-8, Article 16240

2019

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Inhibitory effects of biseokeaniamide A against lipopolysaccharide-induced signal transduction

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (11), p.127069, Article 127069

2020

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FMODB: The World’s First Database of Quantum Mechanical Calculations for Biomacromolecules Based on the Fragment Molecular Orbital Method

Journal of chemical information and modeling, 2021-02, Vol.61 (2), p.777-794

2021

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rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases

Human genetics, 2024-01, Vol.143 (1), p.19-33

2024

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Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.4183-4204

2020

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Mutation in TECPR2 Reveals a Role for Autophagy in Hereditary Spastic Paraparesis

American journal of human genetics, 2012-12, Vol.91 (6), p.1065-1072

2012

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Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3407-3427

2019

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Significance of functional disease-causal/susceptible variants identified by whole-genome analyses for the understanding of human diseases

Proceedings of the Japan Academy, Series B, 2017/11/10, Vol.93(9), pp.657-676

2017

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The ubiquinone synthesis pathway is a promising drug target for Chagas disease

PloS one, 2021-02, Vol.16 (2), p.e0243855-e0243855

2021

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Statistical analysis of interactions among amino acid residues in apo structures using fragment molecular orbital method

Chem-Bio Informatics Journal, 2024/06/28, Vol.24, pp.25-47

2024

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Prediction of sites of metabolism in a substrate molecule, instanced by carbamazepine oxidation by CYP3A4

Bioorganic & medicinal chemistry, 2012-01, Vol.20 (2), p.775-783

2012

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Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population

European journal of human genetics : EJHG, 2021-08, Vol.29 (8), p.1282-1291

2021

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A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides

Journal of autoimmunity, 2021-01, Vol.116, p.102571-102571, Article 102571

2021

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Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis

Scientific reports, 2017-06, Vol.7 (1), p.2904-10, Article 2904

2017

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Quantitative prediction of hERG inhibitory activities using support vector regression and the integrated hERG dataset in AMED cardiotoxicity database

Chem-Bio Informatics Journal, 2021/10/01, Vol.21, pp.70-80

2021

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IKZF1 , a new susceptibility gene for cold medicine–related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement

Journal of allergy and clinical immunology, 2015-06, Vol.135 (6), p.1538-1545.e17

2015

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Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis

Scientific reports, 2018-08, Vol.8 (1), p.11808-11, Article 11808

2018

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Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population

Frontiers in immunology, 2023, Vol.14, p.1151502-1151502

2023

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Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II

Construction of an integrated database for hERG blocking small molecules

The Genetics of Primary Biliary Cholangitis: A GWAS and Post-GWAS Update

Clinical application of exome sequencing in undiagnosed genetic conditions

Principal contribution of HLA-DQ alleles, DQB106:04 and DQB103:01, to disease resistance against primary biliary cholangitis in a Japanese population

Analysis of whole Y-chromosome sequences reveals the Japanese population history in the Jomon period

rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis

Identification of HLA-A02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing

Inhibitory effects of biseokeaniamide A against lipopolysaccharide-induced signal transduction

FMODB: The World’s First Database of Quantum Mechanical Calculations for Biomacromolecules Based on the Fragment Molecular Orbital Method

rs10924104 in the expression enhancer motif of CD58 confers susceptibility to human autoimmune diseases

Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer

Mutation in TECPR2 Reveals a Role for Autophagy in Hereditary Spastic Paraparesis

Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors

Significance of functional disease-causal/susceptible variants identified by whole-genome analyses for the understanding of human diseases

The ubiquinone synthesis pathway is a promising drug target for Chagas disease

Statistical analysis of interactions among amino acid residues in apo structures using fragment molecular orbital method

Prediction of sites of metabolism in a substrate molecule, instanced by carbamazepine oxidation by CYP3A4

Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population

A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides

Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis

Quantitative prediction of hERG inhibitory activities using support vector regression and the integrated hERG dataset in AMED cardiotoxicity database

IKZF1 , a new susceptibility gene for cold medicine–related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement

Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis

Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population

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