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Synthesis and evaluation of tripeptidic plasmin inhibitors with nitrile as warhead

Journal of peptide science, 2012-10, Vol.18 (10), p.620-625

2012

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Structure-inhibitory activity relationship of plasmin and plasma kallikrein inhibitors

Chemical & pharmaceutical bulletin, 2001-11, Vol.49 (11), p.1457-1463

2001

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Binding Diversity of a Noncovalent-Type Low-Molecular-Weight Serine Protease Inhibitor and Function of a Catalytic Water Molecule: X-Ray Crystal Structure of PKSI-527-Inhibited Trypsin

Journal of biochemistry (Tokyo), 2001-03, Vol.129 (3), p.455-460

2001

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Isolation of Plasma Kallikrein by High Efficiency Affinity Chromatography and Its Characterization

Biological and Pharmaceutical Bulletin, 2001, Vol.24(5), pp.520-524

2001

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Development of Potent and Selective Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Activity Relationship

Chemical and Pharmaceutical Bulletin, 2000/12/01, Vol.48(12), pp.1964-1972

2000

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Selective Inhibition of Trypsin by (2R,4R)-4-Phenyl-1-[Nα-(7- methoxy-2-naphthalenesulfonyl)-l-arginyl]-2-piperidinecarboxylic Acid

The Journal of biological chemistry, 2000-06, Vol.275 (25), p.18995-18999

2000

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Development of plasma kallikrein selective inhibitors

BIOPOLYM, 1999, Vol.51 (1), p.41-50

1999

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A Strategy for a Rational Approach to Designing Synthetic Selective Inhibitors

Seminars in thrombosis and hemostasis, 1992-01, Vol.18 (1), p.135-149

1992

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Development of Plasmin-Selective Inhibitors and Studies of Their Structure-Activity Relationship

Chemical and Pharmaceutical Bulletin, 2000/02/01, Vol.48(2), pp.184-193

2000

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Amino Acids and Peptides. LIII. Synthesis and Biological Activities of Some Pseudo-Peptide Analogs of PKSI-527, a Plasma Kallikrein Selective Inhibitor : The Importance of the Peptide Backbone

Chemical and Pharmaceutical Bulletin, 1999/08/15, Vol.47(8), pp.1141-1144

1999

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Use of an active center-directed plasmin inhibitor elucidates the multiplicity of plasmin actions

Thrombosis research, 1996-04, Vol.82 (1), p.79-86

1996

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Purification Method for Human Plasma Kallikrein by a New Affinity Chromatography

Biological and Pharmaceutical Bulletin, 1998/02/15, Vol.21(2), pp.105-108

1998

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Design of Plasma Kallikrein Inhibitors : Functional and Structural Requirements of Plasma Kallikrein Inhibitors

Chemical and Pharmaceutical Bulletin, 1998/03/15, Vol.46(3), pp.452-457

1998

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Development of Active Center-Directed Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Inhibitory Activity Relationship

Chemical and Pharmaceutical Bulletin, 1993/06/15, Vol.41(6), pp.1079-1090

1993

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Enzyme-Controlling Medicines: Introduction

Seminars in thrombosis and hemostasis, 1997-01, Vol.23 (6), p.493-501

1997

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Development of Active Center-Directed Inhibitors against Plasmin

Chemical and Pharmaceutical Bulletin, 1991/09/25, Vol.39(9), pp.2340-2346

1991

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Synthesis of active center-directed peptide inhibitors of plasmin

Chemical & pharmaceutical bulletin, 1988, Vol.36 (4), p.1289-1297

1988

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Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and ht29 cell lines

Bioorganic & medicinal chemistry letters, 2000-10, Vol.10 (19), p.2217-2221

2000

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Development of Selective Inhibitors against Plasma Kallikrein

Chemical and Pharmaceutical Bulletin, 1991/11/25, Vol.39(11), pp.2930-2936

1991

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Synthetic selective inhibitors of thrombin

Methods in enzymology, 1993, Vol.222, p.328

1993

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Effect of a synthetic thrombin-inhibitor MD805 on the reaction between thrombin and plasma antithrombin-III

Thrombosis research, 1990-09, Vol.59 (6), p.967-977

1990

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A simple and quantitative method for the determination of tissue factor

Southeast Asian journal of tropical medicine and public health, 1997, Vol.28, p.161-163

1997

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A new method for the determination of prothrombin in human plasma

Thrombosis research, 1990-03, Vol.57 (5), p.705-715

Hijikata-Okunomiya, Akiko

1990

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An evaluation of prothrombin assay method using MD805 by means of warfarin-treated plasma

Thrombosis research, 1991-12, Vol.64 (5), p.559-569

1991

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Structure-inhibitory activity relationship of plasmin and plasma kallikrein inhibitors1

Chemical & pharmaceutical bulletin, 2001, Vol.49 (11), p.1457-1463

2001

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Synthesis and evaluation of tripeptidic plasmin inhibitors with nitrile as warhead

Structure-inhibitory activity relationship of plasmin and plasma kallikrein inhibitors

Binding Diversity of a Noncovalent-Type Low-Molecular-Weight Serine Protease Inhibitor and Function of a Catalytic Water Molecule: X-Ray Crystal Structure of PKSI-527-Inhibited Trypsin

Isolation of Plasma Kallikrein by High Efficiency Affinity Chromatography and Its Characterization

Development of Potent and Selective Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Activity Relationship

Selective Inhibition of Trypsin by (2R,4R)-4-Phenyl-1-[Nα-(7- methoxy-2-naphthalenesulfonyl)-l-arginyl]-2-piperidinecarboxylic Acid

Development of plasma kallikrein selective inhibitors

A Strategy for a Rational Approach to Designing Synthetic Selective Inhibitors

Development of Plasmin-Selective Inhibitors and Studies of Their Structure-Activity Relationship

Amino Acids and Peptides. LIII. Synthesis and Biological Activities of Some Pseudo-Peptide Analogs of PKSI-527, a Plasma Kallikrein Selective Inhibitor : The Importance of the Peptide Backbone

Use of an active center-directed plasmin inhibitor elucidates the multiplicity of plasmin actions

Purification Method for Human Plasma Kallikrein by a New Affinity Chromatography

Design of Plasma Kallikrein Inhibitors : Functional and Structural Requirements of Plasma Kallikrein Inhibitors

Development of Active Center-Directed Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Inhibitory Activity Relationship

Enzyme-Controlling Medicines: Introduction

Development of Active Center-Directed Inhibitors against Plasmin

Synthesis of active center-directed peptide inhibitors of plasmin

Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and ht29 cell lines

Development of Selective Inhibitors against Plasma Kallikrein

Synthetic selective inhibitors of thrombin

Effect of a synthetic thrombin-inhibitor MD805 on the reaction between thrombin and plasma antithrombin-III

A simple and quantitative method for the determination of tissue factor

A new method for the determination of prothrombin in human plasma

An evaluation of prothrombin assay method using MD805 by means of warfarin-treated plasma

Structure-inhibitory activity relationship of plasmin and plasma kallikrein inhibitors1

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