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Elucidation of Degradation Behavior of Barbiturates in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (V)

Chemical and Pharmaceutical Bulletin, 2024/08/07, Vol.72(8), pp.747-750

2024

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Elucidation of Degradation Behavior of Nitrazepam, a Benzodiazepine Drug, under Basic Conditions: Study on Degradability of Drugs in Stomach (IV)

Chemical and Pharmaceutical Bulletin, 2024/01/01, Vol.72(1), pp.11-15

2024

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Transition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N-Propargyl Enamines

Synthesis (Stuttgart), 2020-04, Vol.52 (7), p.1113-1121

2020

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Design and Synthesis of a Piperidinone Scaffold as an Analgesic through Kappa-Opioid Receptor: Structure–Activity Relationship Study of Matrine Alkaloids

Chemical and Pharmaceutical Bulletin, 2016/05/01, Vol.64(5), pp.410-419

2016

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Development of κ Opioid Receptor Agonists by Focusing on Phenyl Substituents of 4-Dimethylamino-3-phenylpiperidine Derivatives: Structure–Activity Relationship Study of Matrine Type Alkaloids

Chemical and Pharmaceutical Bulletin, 2016/05/01, Vol.64(5), pp.420-431

2016

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Bisoxazoline-Catalyzed Asymmetric Nucleophilic Addition of Diethyl Zinc to Fluorinated Alkyl Ketones: Enantiofacial Control by Changing the Bisoxazoline Substituent

Bulletin of the Chemical Society of Japan, 2015-01, Vol.88 (1), p.200-208

2015

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Effect of p-aminophenols on tyrosinase activity

Bioorganic & medicinal chemistry, 2014-08, Vol.22 (15), p.3994-4000

2014

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Efficient microwave-assisted prenylation of pinostrobin and biological evaluation of its derivatives as antitumor agents

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2086-2089

2010

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Development of κ Opioid Receptor Agonists by Focusing on Phenyl Substituents of 4-Dimethylamino-3-phenylpiperidine Derivatives : Structure-Activity Relationship Study of Matrine Type Alkaloids

Chemical and Pharmaceutical Bulletin, 2016-05, Vol.64 (5), p.420-431

2016

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Transition Metal-Free Cyclization of N-Boc-N-propargylenamines

Heterocycles, 2020-05, Vol.100 (5), p.719

2020

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Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT

Psychopharmacology, 2016-06, Vol.233 (12), p.2343-2353

2016

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Differential substitution for the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine and methylphenidate in rats

The Journal of pharmacology and experimental therapeutics, 2014-08, Vol.350 (2), p.403-411

2014

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Usefulness for the combination of G protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance

Molecular pain, 2017-01, Vol.13, p.1744806917740030-1744806917740030

2017

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Overview of 43 Years of Studies on Asymmetric Synthesis

YAKUGAKU ZASSHI, 2020/02/01, Vol.140(2), pp.273-287

Higashiyama, Kimio

2020

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Overview of 43 Years of Studies on Asymmetric Synthesis

Yakugaku zasshi, 2020-02, Vol.140 (2), p.273-287

Higashiyama, Kimio

2020

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Concise Total Synthesis of (−)-Deoxocuscohygrine and (−)-Dihydrocuscohygrine

Journal of organic chemistry, 2008-12, Vol.73 (24), p.9784-9787

2008

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Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice

Psychopharmacology, 2008-10, Vol.200 (3), p.307-316

2008

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Total Synthesis of the Proposed Structures of Eushearilide

Heterocycles, 2014, Vol.88 (2), p.1175

2014

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p‐Dodecylaminophenol derived from the synthetic retinoid, fenretinide: Antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action

International journal of cancer, 2008-02, Vol.122 (3), p.689-698

2008

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Hypoglycemic Effects of Multiflorine Derivatives in Normal Mice

Biological and Pharmaceutical Bulletin, 2006, Vol.29(10), pp.2046-2050

2006

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Chemoselective reduction of ketones: trifluoromethylketones versus methylketones

Tetrahedron letters, 2005-02, Vol.46 (9), p.1497-1500

2005

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Highly Regioselective Hydrogenolysis of Bis(α-methylbenzyl)amine Derivatives Affected by the Trifluoromethyl Substituent on the Aromatic Ring

Organic letters, 2003-04, Vol.5 (7), p.1007-1010

2003

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Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine

Biochemical and biophysical research communications, 2021-01, Vol.534, p.988-994

2021

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Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine

British journal of cancer, 2022-11, Vol.127 (8), p.1565-1574

2022

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STRUCTURE MODIFICATION OF ANDROGRAPHOLIDE TO IMPROVE ITS POTENCY AS ANTICANCER

Indonesian journal of chemistry, 2010-06, Vol.7 (2), p.202-207

2010

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Elucidation of Degradation Behavior of Barbiturates in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (V)

Elucidation of Degradation Behavior of Nitrazepam, a Benzodiazepine Drug, under Basic Conditions: Study on Degradability of Drugs in Stomach (IV)

Transition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N-Propargyl Enamines

Design and Synthesis of a Piperidinone Scaffold as an Analgesic through Kappa-Opioid Receptor: Structure–Activity Relationship Study of Matrine Alkaloids

Development of κ Opioid Receptor Agonists by Focusing on Phenyl Substituents of 4-Dimethylamino-3-phenylpiperidine Derivatives: Structure–Activity Relationship Study of Matrine Type Alkaloids

Bisoxazoline-Catalyzed Asymmetric Nucleophilic Addition of Diethyl Zinc to Fluorinated Alkyl Ketones: Enantiofacial Control by Changing the Bisoxazoline Substituent

Effect of p-aminophenols on tyrosinase activity

Efficient microwave-assisted prenylation of pinostrobin and biological evaluation of its derivatives as antitumor agents

Development of κ Opioid Receptor Agonists by Focusing on Phenyl Substituents of 4-Dimethylamino-3-phenylpiperidine Derivatives : Structure-Activity Relationship Study of Matrine Type Alkaloids

Transition Metal-Free Cyclization of N-Boc-N-propargylenamines

Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT

Differential substitution for the discriminative stimulus effects of 3,4-methylenedioxymethamphetamine and methylphenidate in rats

Usefulness for the combination of G protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance

Overview of 43 Years of Studies on Asymmetric Synthesis

Overview of 43 Years of Studies on Asymmetric Synthesis

Concise Total Synthesis of (−)-Deoxocuscohygrine and (−)-Dihydrocuscohygrine

Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice

Total Synthesis of the Proposed Structures of Eushearilide

p‐Dodecylaminophenol derived from the synthetic retinoid, fenretinide: Antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action

Hypoglycemic Effects of Multiflorine Derivatives in Normal Mice

Chemoselective reduction of ketones: trifluoromethylketones versus methylketones

Highly Regioselective Hydrogenolysis of Bis(α-methylbenzyl)amine Derivatives Affected by the Trifluoromethyl Substituent on the Aromatic Ring

Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine

Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine

STRUCTURE MODIFICATION OF ANDROGRAPHOLIDE TO IMPROVE ITS POTENCY AS ANTICANCER

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