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Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency

G3 : genes - genomes - genetics, 2024-05, Vol.14 (5)

2024

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Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases

G3 : genes - genomes - genetics, 2023-08, Vol.13 (8)

2023

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Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases

Genetics (Austin), 2023-08, Vol.224 (4)

2023

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ModelMatcher: A scientist‐centric online platform to facilitate collaborations between stakeholders of rare and undiagnosed disease research

Human mutation, 2022-06, Vol.43 (6), p.743-759

2022

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Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2

Life science alliance, 2021-11, Vol.4 (11), p.e202101083

2021

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A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis

Cell cycle (Georgetown, Tex.), 2021-07, Vol.20 (14), p.1361-1373

2021

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Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (14), p.1

2021

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Mapping Synthetic Dosage Lethal Genetic Interactions in Saccharomyces cerevisiae

Methods in molecular biology (Clifton, N.J.), 2021, Vol.2381, p.39

2021

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A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in Caenorhabditis elegans

Genetics (Austin), 2020-07, Vol.215 (3), p.609-621

2020

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Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins

Genetics (Austin), 2020-03, Vol.214 (3), p.735-747

2020

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Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins

Genetics (Austin), 2020-03, Vol.214 (3), p.735

2020

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MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts

Nature communications, 2019-09, Vol.10 (1), p.4265-15, Article 4265

2019

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MinION-based long-read sequencing and assembly extends the Caenorhabditis elegans reference genome

Genome research, 2018-02, Vol.28 (2), p.266

2018

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The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast

Methods in molecular biology (Clifton, N.J.), 2018-01, Vol.1672, p.11

2018

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Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability

Journal of molecular biology, 2017-10, Vol.429 (21), p.3132-3138

2017

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Synthetic lethality and cancer

Nature reviews. Genetics, 2017-10, Vol.18 (10), p.613

2017

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Abstract A04: Cross-species analysis identifies MUS81, a structure-specific endonuclease, as a novel synthetic lethal interaction with PARP

Molecular cancer therapeutics, 2017-10, Vol.16 (10_Supplement), p.A04-A04

2017

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Abstract PR01: A functional variomic chemi-genetic screen in C. elegans identifies new synthetic lethal interactions with PARP inhibition that are conserved from worm to human

Molecular cancer therapeutics, 2017-10, Vol.16 (10_Supplement), p.PR01-PR01

2017

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Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

Genetics (Austin), 2016-11, Vol.204 (3), p.975-986

2016

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Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer

Proceedings of the National Academy of Sciences - PNAS, 2016-09, Vol.113 (36), p.9967-9976

2016

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Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint

Genetics (Austin), 2015-11, Vol.201 (3), p.885-895

2015

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Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants

Genetics (Austin), 2015-11, Vol.201 (3), p.1263-1274

2015

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An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes

G3 : genes - genomes - genetics, 2015-09, Vol.5 (9), p.1879-1887

2015

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Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency

Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases

Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases

ModelMatcher: A scientist‐centric online platform to facilitate collaborations between stakeholders of rare and undiagnosed disease research

Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2

A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis

Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions

Mapping Synthetic Dosage Lethal Genetic Interactions in Saccharomyces cerevisiae

A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in Caenorhabditis elegans

Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins

Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins

The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts

MinION-based long-read sequencing and assembly extends the Caenorhabditis elegans reference genome

The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast

Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability

Synthetic lethality and cancer

Abstract A04: Cross-species analysis identifies MUS81, a structure-specific endonuclease, as a novel synthetic lethal interaction with PARP

Abstract PR01: A functional variomic chemi-genetic screen in C. elegans identifies new synthetic lethal interactions with PARP inhibition that are conserved from worm to human

International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases

Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer

Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint

Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants

An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes

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