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The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

Pharmacology & therapeutics (Oxford), 2002-02, Vol.93 (2), p.225-232

2002

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IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (3), p.831-834

2014

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The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats

Cells (Basel, Switzerland), 2021-12, Vol.11 (1), p.66

2021

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Inhibition of Rho‐kinase‐induced myristoylated alanine‐rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H‐1152, a novel and specific Rho‐kinase inhibitor

Journal of neurochemistry, 2002-04, Vol.81 (1), p.9-16

2002

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K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model

PloS one, 2012-10, Vol.7 (10), p.e46432-e46432

2012

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Efficient synthesis of [11C]H-1152, a PET probe specific for Rho-kinases, highly potential targets in diagnostic medicine and drug development

Tetrahedron, 2012-03, Vol.68 (10), p.2336-2341

2012

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The Effect of the H-1152P, a Potent Rho-Associated Coiled Coil-Formed Protein Kinase Inhibitor, in Rabbit Normal and Ocular Hypertensive Eyes

Current eye research, 2009-01, Vol.34 (4), p.282-286

2009

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Regulation of Neuronal Nitric-oxide Synthase by Calmodulin Kinases

The Journal of biological chemistry, 1999-07, Vol.274 (29), p.20597-20602

1999

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The Effect of the Rho-Associated Protein Kinase Inhibitor, HA-1077, in the Rabbit Ocular Hypertension Model Induced by Water Loading

Current eye research, 2009, Vol.34 (1), p.42-47

2009

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Calcium/Calmodulin-dependent Phosphorylation and Activation of Human Cdc25-C at the G2/M Phase Transition in HeLa Cells

The Journal of biological chemistry, 1999-03, Vol.274 (12), p.7958-7968

1999

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The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells

Biochemical and biophysical research communications, 1991-12, Vol.181 (3), p.968-975

1991

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Investigation of binding proteins for anti-platelet agent K-134 by Drug-Western method

Biochemical and biophysical research communications, 2007-02, Vol.353 (4), p.1111-1114

2007

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The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins

Nature structural & molecular biology, 1995-09, Vol.2 (9), p.790-796

1995

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Calmodulin Antagonists and Cellular Physiology

Hidaka, Hiroyoshi

2012

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The three-dimensional structure of Ca2+-bound calcyclin: implications for Ca2+-signal transduction by S100 proteins

Structure (London), 1998-02, Vol.6 (2), p.223-231

1998

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Phosphorylation of Synaptic Vesicle Protein 2 Modulates Binding to Synaptotagmin

The Journal of biological chemistry, 2000-06, Vol.275 (22), p.17195-17200

2000

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Regulation of Calcyclin (S100A6) Binding by Alternative Splicing in the N-terminal Regulatory Domain of Annexin XI Isoforms

The Journal of biological chemistry, 1998-03, Vol.273 (11), p.6351-6357

1998

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Ca2+ Signaling and Intracellular Ca2+ Binding Proteins

Journal of biochemistry (Tokyo), 1996-10, Vol.120 (4), p.685-698

1996

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Calmodulin antagonists and cellular physiology

1, 1985

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An essential role of myosin light‐chain kinase in the regulation of agonist‐ and fluid flow‐stimulated Ca2+ influx in endothelial cells

The FASEB journal, 1998-03, Vol.12 (3), p.341-348

1998

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Isolation of cDNAs Encoding Cellular Drug-Binding Proteins Using a Novel Expression Cloning Procedure: Drug-Western

Molecular pharmacology, 1999-02, Vol.55 (2), p.356-363

1999

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Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis

FEBS letters, 1999-02, Vol.444 (1), p.11-14

1999

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Evidence for calmodulin inter-domain compaction in solution induced by W-7 binding

FEBS letters, 1999-01, Vol.442 (2), p.173-177

1999

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Development of specific Rho-kinase inhibitors and their clinical application

Biochimica et biophysica acta, 2005-12, Vol.1754 (1), p.245-252

2005

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Suppression of arterial intimal hyperplasia by cilostamide, a cyclic nucleotide phosphodiesterase 3 inhibitor, in a rat balloon double‐injury model

British journal of pharmacology, 2000-05, Vol.130 (2), p.231-241

2000

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The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway

IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys

The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats

Inhibition of Rho‐kinase‐induced myristoylated alanine‐rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H‐1152, a novel and specific Rho‐kinase inhibitor

K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model

Efficient synthesis of [11C]H-1152, a PET probe specific for Rho-kinases, highly potential targets in diagnostic medicine and drug development

The Effect of the H-1152P, a Potent Rho-Associated Coiled Coil-Formed Protein Kinase Inhibitor, in Rabbit Normal and Ocular Hypertensive Eyes

Regulation of Neuronal Nitric-oxide Synthase by Calmodulin Kinases

The Effect of the Rho-Associated Protein Kinase Inhibitor, HA-1077, in the Rabbit Ocular Hypertension Model Induced by Water Loading

Calcium/Calmodulin-dependent Phosphorylation and Activation of Human Cdc25-C at the G2/M Phase Transition in HeLa Cells

The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells

Investigation of binding proteins for anti-platelet agent K-134 by Drug-Western method

The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins

Calmodulin Antagonists and Cellular Physiology

The three-dimensional structure of Ca2+-bound calcyclin: implications for Ca2+-signal transduction by S100 proteins

Phosphorylation of Synaptic Vesicle Protein 2 Modulates Binding to Synaptotagmin

Regulation of Calcyclin (S100A6) Binding by Alternative Splicing in the N-terminal Regulatory Domain of Annexin XI Isoforms

Ca2+ Signaling and Intracellular Ca2+ Binding Proteins

Calmodulin antagonists and cellular physiology

An essential role of myosin light‐chain kinase in the regulation of agonist‐ and fluid flow‐stimulated Ca2+ influx in endothelial cells

Isolation of cDNAs Encoding Cellular Drug-Binding Proteins Using a Novel Expression Cloning Procedure: Drug-Western

Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis

Evidence for calmodulin inter-domain compaction in solution induced by W-7 binding

Development of specific Rho-kinase inhibitors and their clinical application

Suppression of arterial intimal hyperplasia by cilostamide, a cyclic nucleotide phosphodiesterase 3 inhibitor, in a rat balloon double‐injury model

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