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Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis

Amino acids, 2007-08, Vol.33 (2), p.359-366

2007

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Polyamine biosynthetic enzymes as drug targets in parasitic protozoa

Biochemical Society transactions, 2003-04, Vol.31 (2), p.415-419

2003

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DNA methylation and polyamines in embryonic development and cancer

The International journal of developmental biology, 1995-10, Vol.39 (5), p.737

Heby, O

1995

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Skin fibroblasts from spermine synthase-deficient hemizygous gyro male (Gy/Y) mice overproduce spermidine and exhibit increased resistance to oxidative stress but decreased resistance to UV irradiation

Biochemical journal, 2000-12, Vol.352 Pt 2 (2), p.381-387

2000

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Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants

The Journal of biological chemistry, 2004-05, Vol.279 (22), p.23668-23678

2004

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Regulation of ornithine decarboxylase mRNA translation by polyamines. Studies using a cell-free system and a cell line with an amplified ornithine decarboxylase gene

The Journal of biological chemistry, 1988-03, Vol.263 (7), p.3528-3533

1988

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Molecular genetics of polyamine synthesis in eukaryotic cells

Trends in biochemical sciences (Amsterdam. Regular ed.), 1990-04, Vol.15 (4), p.153-158

1990

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Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression

Biochemical journal, 2000-03, Vol.346 Pt 3 (3), p.699-704

2000

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S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers

The Journal of biological chemistry, 2002-02, Vol.277 (8), p.5902-5909

2002

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Feedback control of ornithine decarboxylase expression by polyamines. Analysis of ornithine decarboxylase mRNA distribution in polysome profiles and of translation of this mRNA in vitro

Biochemical journal, 1989-03, Vol.258 (2), p.343-350

1989

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Genetic analysis of spermidine synthase from Leishmania donovani

Molecular and biochemical parasitology, 2001-07, Vol.115 (2), p.217-226

2001

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Role of Polyamines in the Control of Cell Proliferation and Differentiation

Differentiation (London), 1981-01, Vol.19 (1), p.1-20

HEBY, OLLE

1981

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Nuclear translocation of antizyme and expression of ornithine decarboxylase and antizyme are developmentally regulated

Developmental dynamics, 2001-03, Vol.220 (3), p.259-275

2001

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Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme

Biochemical journal, 1998-08, Vol.333 ( Pt 3) (3), p.527-537

1998

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Interference with DNA Methyltransferase Activity and Genome Methylation during F9 Teratocarcinoma Stem Cell Differentiation Induced by Polyamine Depletion

The Journal of biological chemistry, 1997-02, Vol.272 (7), p.4359-4366

1997

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Polyamine-mediated control of ornithine decarboxylase and S-adenosylmethionine decarboxylase expression in mammalian cells

Biochemical Society transactions, 1990-12, Vol.18 (6), p.1084-1087

1990

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Polyamine depletion up-regulates c-Myc expression, yet induces G(1) arrest and terminal differentiation of F9 teratocarcinoma stem cells

Journal of cellular biochemistry, 1999-11, Vol.76 (1), p.143

1999

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Cell cycle phase specificity and therapeutic effectiveness of polyamine synthesis inhibitors

Progress in clinical and biological research, 1983, Vol.132C, p.189

Heby, O

1983

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Polyamine starvation prolongs the S and G2 phases of polyamine-dependent (arginase-deficient) CHO cells

Molecular and Cellular Biology, 1984-05, Vol.4 (5), p.915-922

1984

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Inhibition of Putrescine Synthesis Blocks Development of the Polychete Ophryotrocha labronica at Gastrulation

Proceedings of the National Academy of Sciences - PNAS, 1978-02, Vol.75 (2), p.1039-1042

1978

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Essential role of the polyamines in early chick embryo development

Development (Cambridge), 1980-12, Vol.60 (1), p.83-92

1980

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Regulation of polyamine synthesis in mammalian cells

Advances in experimental medicine and biology, 1988, Vol.250, p.261

1988

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Nuclear ornithine decarboxylase. Electron microscope autoradiographic identification of the active enzyme using alpha-[5-3H]difluoromethylornithine

European journal of cell biology, 1983-05, Vol.30 (2), p.288-294

1983

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Cloning and Sequencing of an Intronless Mouse S-Adenosylmethionine Decarboxylase Gene Coding for a Functional Enzyme Strongly Expressed in the Liver (∗)

The Journal of biological chemistry, 1995-03, Vol.270 (10), p.5642-5648

1995

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Interference with S and G2 phase progression by polyamine synthesis inhibitors

Experimental cell research, 1978-02, Vol.111 (2), p.461-464

1978

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Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis

Polyamine biosynthetic enzymes as drug targets in parasitic protozoa

DNA methylation and polyamines in embryonic development and cancer

Skin fibroblasts from spermine synthase-deficient hemizygous gyro male (Gy/Y) mice overproduce spermidine and exhibit increased resistance to oxidative stress but decreased resistance to UV irradiation

Arginase plays a pivotal role in polyamine precursor metabolism in Leishmania. Characterization of gene deletion mutants

Regulation of ornithine decarboxylase mRNA translation by polyamines. Studies using a cell-free system and a cell line with an amplified ornithine decarboxylase gene

Molecular genetics of polyamine synthesis in eukaryotic cells

Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression

S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers

Feedback control of ornithine decarboxylase expression by polyamines. Analysis of ornithine decarboxylase mRNA distribution in polysome profiles and of translation of this mRNA in vitro

Genetic analysis of spermidine synthase from Leishmania donovani

Role of Polyamines in the Control of Cell Proliferation and Differentiation

Nuclear translocation of antizyme and expression of ornithine decarboxylase and antizyme are developmentally regulated

Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme

Interference with DNA Methyltransferase Activity and Genome Methylation during F9 Teratocarcinoma Stem Cell Differentiation Induced by Polyamine Depletion

Polyamine-mediated control of ornithine decarboxylase and S-adenosylmethionine decarboxylase expression in mammalian cells

Polyamine depletion up-regulates c-Myc expression, yet induces G(1) arrest and terminal differentiation of F9 teratocarcinoma stem cells

Cell cycle phase specificity and therapeutic effectiveness of polyamine synthesis inhibitors

Polyamine starvation prolongs the S and G2 phases of polyamine-dependent (arginase-deficient) CHO cells

Inhibition of Putrescine Synthesis Blocks Development of the Polychete Ophryotrocha labronica at Gastrulation

Essential role of the polyamines in early chick embryo development

Regulation of polyamine synthesis in mammalian cells

Nuclear ornithine decarboxylase. Electron microscope autoradiographic identification of the active enzyme using alpha-[5-3H]difluoromethylornithine

Cloning and Sequencing of an Intronless Mouse S-Adenosylmethionine Decarboxylase Gene Coding for a Functional Enzyme Strongly Expressed in the Liver (∗)

Interference with S and G2 phase progression by polyamine synthesis inhibitors

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