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Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

mAbs, 2020-01, Vol.12 (1), p.1688616-1688616

2020

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Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T

CPT: pharmacometrics and systems pharmacology, 2021-04, Vol.10 (4), p.362-376

2021

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Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N -Acetylgalactosamine-Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans

The Journal of pharmacology and experimental therapeutics, 2021-11, Vol.379 (2), p.134-146

2021

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Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents

mAbs, 2018-08, Vol.10 (6), p.876-889

2018

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Geriatrics 2030: Developing Drugs to Care for Older Persons—A Neglected and Growing Population

Clinical pharmacology and therapeutics, 2020-01, Vol.107 (1), p.53-56

2020

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Pharmacokinetics of topiramate in patients with renal impairment, end-stage renal disease undergoing hemodialysis, or hepatic impairment

Epilepsy research, 2014-07, Vol.108 (5), p.891-901

2014

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An Open-Label Drug–Drug Interaction Study of the Steady-State Pharmacokinetics of Topiramate and Glyburide in Patients with Type 2 Diabetes Mellitus

Clinical drug investigation, 2013-12, Vol.33 (12), p.929-938

2013

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A pharmacokinetic and pharmacodynamic comparison of desmopressin administered as whole, chewed and crushed tablets, and as an oral solution

The Journal of urology, 2001-05, Vol.165 (5), p.1446-1451

2001

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The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil

Clinical pharmacology and therapeutics, 1989-12, Vol.46 (6), p.674-685

1989

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Imaging studies of biodistribution and kinetics in drug development

Drug development research, 2003-06, Vol.59 (2), p.208-226

2003

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Mapping PET-measured triamcinolone acetonide (TAA) aerosol distribution into deposition by airway generation

International journal of pharmaceutics, 2000-04, Vol.199 (1), p.7-16

2000

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In Vivo Characterization of Inhaled Pharmaceuticals Using Quantitative Positron Emission Tomography

Journal of clinical pharmacology, 1999-08, Vol.39 (S1), p.25S-29S

1999

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Biodistribution and Kinetics of Nasal Carbon-11-Triamcinolone Acetonide

The Journal of nuclear medicine (1978), 1998-11, Vol.39 (11), p.1972-1977

1998

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Visualization of Product Performance in the Gut: What Role in the Drug Development/Regulatory Paradigm?

Journal of clinical pharmacology, 1999-08, Vol.39 (S1), p.6S-9S

1999

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Pharmacoscintigraphic evaluation of a modified release (Geomatrix®) diltiazem formulation

Journal of controlled release, 1995, Vol.33 (1), p.89-97

1995

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Regional distribution and kinetics of inhaled pharmaceuticals

Current pharmaceutical design, 2000-11, Vol.6 (16), p.1631-1651

2000

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Pulmonary Distribution and Kinetics of Inhaled [11C]Triamcinolone Acetonide

The Journal of nuclear medicine (1978), 2000-10, Vol.41 (10), p.1603-1611

2000

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A PHARMACOKINETIC AND PHARMACODYNAMIC COMPARISON OF DESMOPRESSIN ADMINISTERED AS WHOLE, CHEWED AND CRUSHED tablets, AND AS AN ORAL SOLUTION

The Journal of urology, 2001-05, p.1446-1451

2001

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The effect of scatter and attenuation on aerosol deposition as determined by gamma scintigraphy

Journal of aerosol medicine, 2001-06, Vol.14 (2), p.167-183

2001

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Imaging studies of biodistribution and kinetics in drug development: PET and SPECT in Medication Development

Drug development research, 2003, Vol.59 (2), p.208-226

2003

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Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

mAbs, 2020, Vol.12 (1)

2020

Volltextzugriff (PDF)

Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents

mAbs, 2018, Vol.10 (6), p.876-889

2018

Volltextzugriff (PDF)

Pharmacoscintigraphic evaluation of a modified release (Geomatrix®) diltiazem formulation: Journal of Controlled Release, 33 (1995) 89–97

Journal of controlled release, 1995-07, Vol.35 (1), p.86-86

1995

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The effect of food on the bioavailability of ebastine

American journal of therapeutics, 1997-02, Vol.4 (2-3), p.80-84

1997

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Uptake and distribution of lidocaine in fetal lambs

Anesthesiology (Philadelphia), 1990-03, Vol.72 (3), p.483-489

1990

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Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T

Minimal Physiologically Based Pharmacokinetic-Pharmacodynamic (mPBPK-PD) Model of N -Acetylgalactosamine-Conjugated Small Interfering RNA Disposition and Gene Silencing in Preclinical Species and Humans

Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents

Geriatrics 2030: Developing Drugs to Care for Older Persons—A Neglected and Growing Population

Pharmacokinetics of topiramate in patients with renal impairment, end-stage renal disease undergoing hemodialysis, or hepatic impairment

An Open-Label Drug–Drug Interaction Study of the Steady-State Pharmacokinetics of Topiramate and Glyburide in Patients with Type 2 Diabetes Mellitus

A pharmacokinetic and pharmacodynamic comparison of desmopressin administered as whole, chewed and crushed tablets, and as an oral solution

The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil

Imaging studies of biodistribution and kinetics in drug development

Mapping PET-measured triamcinolone acetonide (TAA) aerosol distribution into deposition by airway generation

In Vivo Characterization of Inhaled Pharmaceuticals Using Quantitative Positron Emission Tomography

Biodistribution and Kinetics of Nasal Carbon-11-Triamcinolone Acetonide

Visualization of Product Performance in the Gut: What Role in the Drug Development/Regulatory Paradigm?

Pharmacoscintigraphic evaluation of a modified release (Geomatrix®) diltiazem formulation

Regional distribution and kinetics of inhaled pharmaceuticals

Pulmonary Distribution and Kinetics of Inhaled [11C]Triamcinolone Acetonide

A PHARMACOKINETIC AND PHARMACODYNAMIC COMPARISON OF DESMOPRESSIN ADMINISTERED AS WHOLE, CHEWED AND CRUSHED tablets, AND AS AN ORAL SOLUTION

The effect of scatter and attenuation on aerosol deposition as determined by gamma scintigraphy

Imaging studies of biodistribution and kinetics in drug development: PET and SPECT in Medication Development

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

Development of a Target cell-Biologics-Effector cell (TBE) complex-based cell killing model to characterize target cell depletion by T cell redirecting bispecific agents

Pharmacoscintigraphic evaluation of a modified release (Geomatrix®) diltiazem formulation: Journal of Controlled Release, 33 (1995) 89–97

The effect of food on the bioavailability of ebastine

Uptake and distribution of lidocaine in fetal lambs

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