UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 39

Sortiert nach

Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells

Clinical cancer research, 2011-11, Vol.17 (22), p.7067-7079

2011

Link zum Volltext

Verfügbarkeit prüfen

Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5585-5623

2020

Link zum Volltext

Verfügbarkeit prüfen

Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8369-8384

2017

Link zum Volltext

Verfügbarkeit prüfen

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1804-1810

2018

Link zum Volltext

Verfügbarkeit prüfen

Methylpyrrole inhibitors of BET bromodomains

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (10), p.2225-2233

2017

Link zum Volltext

Verfügbarkeit prüfen

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6621-6636

2009

Link zum Volltext

Verfügbarkeit prüfen

Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Journal of medicinal chemistry, 2007-08, Vol.50 (17), p.4162-4176

2007

Link zum Volltext

Verfügbarkeit prüfen

Palladium(II)-Catalyzed Cyclization of Olefinic Tosylamides

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3584-3585

1996

Link zum Volltext

Verfügbarkeit prüfen

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2293-2298

2006

Link zum Volltext

Verfügbarkeit prüfen

Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4001-4005

2003

Link zum Volltext

Verfügbarkeit prüfen

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[ b, e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (7), p.2311-2315

2008

Link zum Volltext

Verfügbarkeit prüfen

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

Cancer research (Chicago, Ill.), 2017-06, Vol.77 (11), p.2976-2989

2017

Link zum Volltext

Verfügbarkeit prüfen

Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2180-2194

2015

Link zum Volltext

Verfügbarkeit prüfen

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.153-158

2005

Link zum Volltext

Verfügbarkeit prüfen

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1359-1362

2003

Link zum Volltext

Verfügbarkeit prüfen

Abstract 931: Discovery of ABBV-744, a first-in-class highly BDII-selective BET bromodomain inhibitor

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.931-931

2018

Link zum Volltext

Verfügbarkeit prüfen

Synthesis and Structure−Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents

Journal of medicinal chemistry, 1996-08, Vol.39 (16), p.3070-3088

1996

Link zum Volltext

Verfügbarkeit prüfen

Abstract 4695: Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4695-4695

2016

Link zum Volltext

Verfügbarkeit prüfen

Abstract 4718: ABBV-075, a novel BET family bromodomain inhibitor, represents a promising therapeutic agent for a broad spectrum of cancer indications

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4718-4718

2016

Link zum Volltext

Verfügbarkeit prüfen

Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: A novel fungicidal lipopeptide-(I)

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.489-493

2003

Link zum Volltext

Verfügbarkeit prüfen

Methylpyrrole inhibitors of BET bromodomains

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (10)

2017

Link zum Volltext

Verfügbarkeit prüfen

1 – 25 von 39

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(38)
Mit Volltextzugriff
(38)

Publikationsform

Artikel
(39)

Sprache

Englisch
(39)
Japanisch
(7)

Erscheinungsjahr

n.n

Thema

Science & Technology
(26)
Life Sciences & Biomedicine
(23)
Chemistry, Medicinal
(21)
Pharmacology & Pharmacy
(21)
Structure-Activity Relationship
(16)
Animals
(15)
Biological And Medical Sciences
(15)
Chemistry
(15)
Chemistry, Organic
(15)
Medical Sciences
(15)
Pharmacology. Drug Treatments
(15)
Physical Sciences
(15)
Humans
(12)
Crystallography, X-Ray
(10)
Antineoplastic Agents
(9)
Cell Line, Tumor
(9)
Mice
(9)
General Aspects
(8)
Models, Molecular
(8)
Enzyme Inhibitors - Chemical Synthesis
(7)

15 weitere anzeigen...

Weniger anzeigen...

Zeitschrift / Serie

5 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

Therapeutic Implications for the Induced Levels of Chk1 in Myc-Expressing Cancer Cells

Discovery of N‑Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo‑1H‑pyrrolo[2,3‑c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Discovery of N -Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1 H -pyrrolo[2,3- c ]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

Discovery of N‑(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro‑1H‑pyrrolo[2,3‑c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors

Methylpyrrole inhibitors of BET bromodomains

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors

Palladium(II)-Catalyzed Cyclization of Olefinic Tosylamides

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[ b, e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity

Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

Abstract 931: Discovery of ABBV-744, a first-in-class highly BDII-selective BET bromodomain inhibitor

Synthesis and Structure−Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents

Abstract 4695: Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075

Abstract 4718: ABBV-075, a novel BET family bromodomain inhibitor, represents a promising therapeutic agent for a broad spectrum of cancer indications

Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: A novel fungicidal lipopeptide-(I)

Methylpyrrole inhibitors of BET bromodomains

Suchergebnisse filtern