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Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1539-1554

2011

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Progress in the medicinal chemistry of silicon: C/Si exchange and beyond

Future medicinal chemistry, 2017-04, Vol.9 (5), p.485-505

2017

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Thalidomide as a Multi-Template for Development of Biologically Active Compounds

Archiv der Pharmazie (Weinheim), 2008-09, Vol.341 (9), p.536-547

Hashimoto, Yuichi

2008

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Protein Knockdown Using Methyl Bestatin−Ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-Mediated Degradation of Cellular Retinoic Acid-Binding Proteins

Journal of the American Chemical Society, 2010-04, Vol.132 (16), p.5820-5826

2010

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Synthesis and evaluation of novel dual BRD4/HDAC inhibitors

Bioorganic & medicinal chemistry, 2017-07, Vol.25 (14), p.3677-3684

2017

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System Development for Tsunami Evacuation Drill Using ICT and Tsunami Inundation Simulation Data

Journal of disaster research, 2024-02, Vol.19 (1), p.72-80

2024

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A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (13), p.7150-7158

2020

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Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand

Bioorganic & medicinal chemistry, 2016-07, Vol.24 (14), p.3144-3148

2016

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Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules

Organic & biomolecular chemistry, 2015-01, Vol.13 (38), p.9746-9750

2015

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Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (4), p.707-710

2018

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Design, synthesis and biological evaluation of nuclear receptor-degradation inducers

Bioorganic & medicinal chemistry, 2011-11, Vol.19 (22), p.6768-6778

2011

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Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives

Bioorganic & medicinal chemistry, 2020-02, Vol.28 (4), p.115310, Article 115310

2020

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Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog

Scientific reports, 2021-06, Vol.11 (1), p.12697-12697, Article 12697

2021

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Design, synthesis and structure–activity relationship of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxyisoprop-2-yl)phenylsilane derivatives as liver X receptor agonists

Bioorganic & medicinal chemistry, 2022-07, Vol.66, p.116792-116792, Article 116792

2022

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Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30

Nature structural & molecular biology, 2017-11, Vol.24 (11), p.911-919

2017

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Guanidine-Thiourea Bifunctional Organocatalyst for the Asymmetric Henry (Nitroaldol) Reaction

Advanced synthesis & catalysis, 2005-10, Vol.347 (11-13), p.1643-1648

2005

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Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs

PloS one, 2020-12, Vol.15 (12), p.e0243746

2020

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Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction Utilizing a Guanidine-Thiourea Bifunctional Organocatalyst

European Journal of Organic Chemistry, 2006-07, Vol.2006 (13), p.2894-2897

2006

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Design, Synthesis and Biological Evaluation of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Phenylamino-1,3,5-triazine Scaffold

Chemical and Pharmaceutical Bulletin, 2019/06/01, Vol.67(6), pp.566-575

2019

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Proposal and evaluation of tsunami disaster drill support system using tablet computer

International journal of information technology (Singapore. Online), 2023-12, Vol.15 (8), p.4029-4039

2023

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CLSPCOL rescues Alzheimer’s disease mouse models

Translational neuroscience, 2022-01, Vol.13 (1), p.11-19

2022

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Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease

Translational psychiatry, 2021-01, Vol.11 (1), p.44-16, Article 44

2021

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Evaluation of Electronic States of Polymer Surface Using Photoelectron Spectroscopy in Air

Electrical engineering in Japan, 2014-07, Vol.188 (2), p.9-17

Hashimoto, Yuichi

2014

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Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4453-4457

2012

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Development of bis-thiourea-type organocatalyst for asymmetric Baylis–Hillman reaction

Tetrahedron letters, 2004-07, Vol.45 (29), p.5589-5592

2004

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Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

Progress in the medicinal chemistry of silicon: C/Si exchange and beyond

Thalidomide as a Multi-Template for Development of Biologically Active Compounds

Protein Knockdown Using Methyl Bestatin−Ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-Mediated Degradation of Cellular Retinoic Acid-Binding Proteins

Synthesis and evaluation of novel dual BRD4/HDAC inhibitors

System Development for Tsunami Evacuation Drill Using ICT and Tsunami Inundation Simulation Data

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate

Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand

Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules

Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers

Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives

Improvement in aqueous solubility of achiral symmetric cyclofenil by modification to a chiral asymmetric analog

Design, synthesis and structure–activity relationship of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxyisoprop-2-yl)phenylsilane derivatives as liver X receptor agonists

Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30

Guanidine-Thiourea Bifunctional Organocatalyst for the Asymmetric Henry (Nitroaldol) Reaction

Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs

Diastereoselective and Enantioselective Henry (Nitroaldol) Reaction Utilizing a Guanidine-Thiourea Bifunctional Organocatalyst

Design, Synthesis and Biological Evaluation of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Phenylamino-1,3,5-triazine Scaffold

Proposal and evaluation of tsunami disaster drill support system using tablet computer

CLSPCOL rescues Alzheimer’s disease mouse models

Restoration of the reduced CLSP activity alleviates memory impairment in Alzheimer disease

Evaluation of Electronic States of Polymer Surface Using Photoelectron Spectroscopy in Air

Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist

Development of bis-thiourea-type organocatalyst for asymmetric Baylis–Hillman reaction

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