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Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Cancer research (Chicago, Ill.), 2001-12, Vol.61 (24), p.8758-8768

2001

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Comparison of closed chamber and open chamber evaporimetry

Skin research and technology, 2009-02, Vol.15 (1), p.51-54

2009

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Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase

Bioorganic & medicinal chemistry letters, 1999-12, Vol.9 (23), p.3301-3306

1999

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Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2409-2421

1999

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Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase

Journal of medicinal chemistry, 1999-08, Vol.42 (17), p.3356-3368

1999

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Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment: Potent Macrocyclic Inhibitors of Farnesyltransferase

Journal of the American Chemical Society, 2001-03, Vol.123 (9), p.2107-2108

2001

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2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase

Journal of medicinal chemistry, 1996-03, Vol.39 (7), p.1345-1348

1996

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Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase

Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (14), p.1991-1996

1999

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alpha(v)beta(3) Integrin antagonists as inhibitors of bone resorption

Expert opinion on investigational drugs, 2000-06, Vol.9 (6), p.1281-1291

2000

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Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist

Journal of medicinal chemistry, 2000-10, Vol.43 (20), p.3736-3745

2000

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Property-based design of KDR kinase inhibitors

Current medicinal chemistry, 2004-03, Vol.11 (6), p.709

2004

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Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa

Blood, 1999-07, Vol.94 (2), p.587-599

1999

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Farnesyltransferase inhibitors and anti-Ras therapy

Breast cancer research and treatment, 1996-01, Vol.38 (1), p.75-83

1996

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Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs

Journal of medicinal chemistry, 1996-11, Vol.39 (23), p.4583-4591

1996

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Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217

The Journal of pharmacology and experimental therapeutics, 1996-07, Vol.278 (1), p.62

1996

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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (17), p.1943-1948

2000

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Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors

Bioorganic & medicinal chemistry letters, 1999-03, Vol.9 (6), p.863-868

1999

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Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists

Journal of medicinal chemistry, 1997-06, Vol.40 (12), p.1779-1788

1997

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In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate

Drug metabolism and disposition, 1997-08, Vol.25 (8), p.978

1997

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Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics

Biochemical Society transactions, 1996-08, Vol.24 (3), p.688

1996

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.761-764

2005

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Anions Modulate the Potency of Geranylgeranyl-Protein Transferase I Inhibitors

The Journal of biological chemistry, 2001-07, Vol.276 (27), p.24457-24465

2001

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Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors

Journal of medicinal chemistry, 1992-08, Vol.35 (16), p.3027-3033

1992

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Pharmacokinetics and pharmacodynamics of L-703,014, a potent fibrinogen receptor antagonist, after intravenous and oral administration in the dog

Pharmaceutical research, 1994-03, Vol.11 (3), p.426-431

1994

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Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Comparison of closed chamber and open chamber evaporimetry

Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase

Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase

Conformational Restriction of Flexible Ligands Guided by the Transferred NOE Experiment: Potent Macrocyclic Inhibitors of Farnesyltransferase

2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase

Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase

alpha(v)beta(3) Integrin antagonists as inhibitors of bone resorption

Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist

Property-based design of KDR kinase inhibitors

Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa

Farnesyltransferase inhibitors and anti-Ras therapy

Non-Peptide Glycoprotein IIb/IIIa Antagonists. 11. Design and in Vivo Evaluation of 3,4-Dihydro-1(1H)-isoquinolinone-Based Antagonists and Ethyl Ester Prodrugs

Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217

Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors

Design and Biological Activity of (S)-4-(5-{[1-(3-Chlorobenzyl)-2- oxopyrrolidin-3-ylamino]methyl}imidazol-1-ylmethyl)benzonitrile, a 3-Aminopyrrolidinone Farnesyltransferase Inhibitor with Excellent Cell Potency

Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors

Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists

In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate

Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Anions Modulate the Potency of Geranylgeranyl-Protein Transferase I Inhibitors

Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors

Pharmacokinetics and pharmacodynamics of L-703,014, a potent fibrinogen receptor antagonist, after intravenous and oral administration in the dog

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