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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

mAbs, 2010-11, Vol.2 (6), p.613-624

2010

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Challenges and Strategies for a Thorough Characterization of Antibody Acidic Charge Variants

Bioengineering (Basel), 2022-11, Vol.9 (11), p.641

2022

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Non-enzymatic hinge region fragmentation of antibodies in solution

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-04, Vol.818 (2), p.115-121

2005

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Determination of critical quality attributes for monoclonal antibodies using quality by design principles

Biologicals, 2016-09, Vol.44 (5), p.291-305

2016

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Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies

Drug development research, 2004-03, Vol.61 (3), p.137-154

2004

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Effect of Copper Sulfate on Performance of a Serum-Free CHO Cell Culture Process and the Level of Free Thiol in the Recombinant Antibody Expressed

Biotechnology progress, 2005-03, Vol.21 (2), p.550-553

2005

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Characterization of Oligosaccharides in Recombinant Tissue Plasminogen Activator Produced in Chinese Hamster Ovary Cells: Two Decades of Analytical Technology Development

Analytical chemistry (Washington), 2009-12, Vol.81 (23), p.9744-9754

2009

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A sensitive mutation screening method supporting cell line development for biotherapeutics

Analytical biochemistry, 2016-07, Vol.505, p.73-75

2016

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Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain

Biochemistry (Easton), 1991-03, Vol.30 (9), p.2311-2314

1991

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O-Linked fucose and other post-translational modifications unique to EGF modules

Glycobiology (Oxford), 1993-06, Vol.3 (3), p.219-224

1993

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Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase

The Journal of biological chemistry, 2001-10, Vol.276 (43), p.40338-40345

2001

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Assessing Genetic Heterogeneity in Production Cell Lines: Detection by Peptide Mapping of a Low Level Tyr to Gln Sequence Variant in a Recombinant Antibody

Bio/technology (New York, N.Y. 1983), 1993-11, Vol.11 (11), p.1293-1297

1993

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Identification and structural analysis of the tetrasaccharide NeuAc.alpha.(2.fwdarw.6)Gal.beta.(1.fwdarw.4)GlcNAc.beta.(1.fwdarw.3)Fuc.alpha.1.fwdarw.O-linked to serine 61 of human factor IX

Biochemistry (Easton), 1993-07, Vol.32 (26), p.6539-6547

1993

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Modification of Epidermal Growth Factor-like Repeats withO-Fucose

The Journal of biological chemistry, 2001-10, Vol.276 (43), p.40338-40345

2001

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Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture

Journal of Chromatography A, 1995-06, Vol.705 (1), p.129-134

Harris, Reed J.

1995

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Identification of multiple sources of charge heterogeneity in a recombinant antibody

Journal of chromatography. B, Biomedical sciences and applications, 2001-03, Vol.752 (2), p.233-245

2001

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Purification of recombinant human tissue factor

Biochemistry (Easton), 1989-10, Vol.28 (20), p.8072-8077

1989

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Enzymatic Removal of Sialic Acid from Human Factor IX and Factor X Has No Effect on Their Coagulant Activity

The Journal of biological chemistry, 1995-03, Vol.270 (12), p.6537-6542

1995

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Modification of CD4 Immunoadhesin with Monomethoxypoly(Ethylene Glycol) Aldehyde via Reductive Alkylation

Bioconjugate chemistry, 1994-03, Vol.5 (2), p.133-140

1994

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Enzymic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments

Biochemistry (Easton), 1990-10, Vol.29 (42), p.9885-9891

1990

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100 Years Ago in "The Auk"

The Auk, 1998-01, Vol.115 (1), p.276-277

J. Harris Reed

1998

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Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies: Monoclonal antibodies as drugs

Drug development research, 2004, Vol.61 (3), p.137-154

2004

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O-linked fucose is present in the first epidermal growth factor domain of factor XII but not protein C

The Journal of biological chemistry, 1992-03, Vol.267 (8), p.5102-5107

1992

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Identification of succinimide sites in proteins by N‐terminal sequence analysis after alkaline hydroxylamine cleavage

Protein science, 1994-01, Vol.3 (1), p.147-149

1994

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Hydroxylation of Lys Residues Reduces Their Susceptibility to Digestion by Trypsin and Lysyl Endopeptidase

Analytical biochemistry, 1998-04, Vol.258 (1), p.136-137

1998

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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

Challenges and Strategies for a Thorough Characterization of Antibody Acidic Charge Variants

Non-enzymatic hinge region fragmentation of antibodies in solution

Determination of critical quality attributes for monoclonal antibodies using quality by design principles

Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies

Effect of Copper Sulfate on Performance of a Serum-Free CHO Cell Culture Process and the Level of Free Thiol in the Recombinant Antibody Expressed

Characterization of Oligosaccharides in Recombinant Tissue Plasminogen Activator Produced in Chinese Hamster Ovary Cells: Two Decades of Analytical Technology Development

A sensitive mutation screening method supporting cell line development for biotherapeutics

Tissue plasminogen activator has an O-linked fucose attached to threonine-61 in the epidermal growth factor domain

O-Linked fucose and other post-translational modifications unique to EGF modules

Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase

Assessing Genetic Heterogeneity in Production Cell Lines: Detection by Peptide Mapping of a Low Level Tyr to Gln Sequence Variant in a Recombinant Antibody

Identification and structural analysis of the tetrasaccharide NeuAc.alpha.(2.fwdarw.6)Gal.beta.(1.fwdarw.4)GlcNAc.beta.(1.fwdarw.3)Fuc.alpha.1.fwdarw.O-linked to serine 61 of human factor IX

Modification of Epidermal Growth Factor-like Repeats withO-Fucose

Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture

Identification of multiple sources of charge heterogeneity in a recombinant antibody

Purification of recombinant human tissue factor

Enzymatic Removal of Sialic Acid from Human Factor IX and Factor X Has No Effect on Their Coagulant Activity

Modification of CD4 Immunoadhesin with Monomethoxypoly(Ethylene Glycol) Aldehyde via Reductive Alkylation

Enzymic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments

100 Years Ago in "The Auk"

Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies: Monoclonal antibodies as drugs

O-linked fucose is present in the first epidermal growth factor domain of factor XII but not protein C

Identification of succinimide sites in proteins by N‐terminal sequence analysis after alkaline hydroxylamine cleavage

Hydroxylation of Lys Residues Reduces Their Susceptibility to Digestion by Trypsin and Lysyl Endopeptidase

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