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Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration

PLoS pathogens, 2021-07, Vol.17 (7), p.e1009682-e1009682

2021

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Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPMPZQ by PZQ, enhanced Ca++ influx, spastic paralysis, and tegumental disrupture—the deadly cascade in parasitic schistosomes, other trematodes, and cestodes

Parasitology research (1987), 2020-08, Vol.119 (8), p.2371-2382

Harder, Achim

2020

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Activation of transient receptor potential channel Sm.TRPM.sub.PZQ by PZQ, enhanced Ca.sup.++ influx, spastic paralysis, and tegumental disrupture-the deadly cascade in parasitic schistosomes, other trematodes, and cestodes

Parasitology research (1987), 2020-08, Vol.119 (8), p.2371

Harder, Achim

2020

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Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside

International journal for parasitology -- drugs and drug resistance, 2021-12, Vol.17, p.27-35

2021

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Phylogenetic characterization of β-tubulins and development of pyrosequencing assays for benzimidazole resistance in cattle nematodes

PloS one, 2013-08, Vol.8 (8), p.e70212-e70212

2013

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Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside

PLoS neglected tropical diseases, 2014-12, Vol.8 (12), p.e3401-e3401

2014

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The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits

PLoS neglected tropical diseases, 2015-10, Vol.9 (10), p.e0004062-e0004062

2015

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SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants

PLoS pathogens, 2011-04, Vol.7 (4), p.e1001330

2011

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Efficacy of cyclooctadepsipeptides and aminophenylamidines against larval, immature and mature adult stages of a parasitologically characterized trichurosis model in mice

PLoS neglected tropical diseases, 2014-02, Vol.8 (2), p.e2698

2014

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Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPM PZQ by PZQ, enhanced Ca ++ influx, spastic paralysis, and tegumental disrupture-the deadly cascade in parasitic schistosomes, other trematodes, and cestodes

Parasitology research (1987), 2020-08, Vol.119 (8), p.2371

Harder, Achim

2020

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Interactions of anthelmintic drugs in Caenorhabditis elegans neuro-muscular ion channel mutants

Parasitology international, 2013-12, Vol.62 (6), p.591-598

2013

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Anthelmintic cyclooctadepsipeptides: complex in structure and mode of action

Trends in parasitology, , Vol.28 (9), p.385-394

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An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria

Proceedings of the National Academy of Sciences - PNAS, 2001-01, Vol.98 (1), p.60-62

2001

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PF1022A and related cyclodepsipeptides - a novel class of anthelmintics

Current topics in medicinal chemistry, 2002-07, Vol.2 (7), p.759

2002

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Praziquantel – 50 Years of Research

ChemMedChem, 2023-06, Vol.18 (12), p.e202300154-n/a

2023

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An Anthelmintic Compound, Nafuredin, Shows Selective Inhibition of Complex I in Helminth Mitochondria

Proceedings of the National Academy of Sciences - PNAS, 2001-01, Vol.98 (1), p.60-62

2001

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Cyclooctadepsipeptides: a new class of anthelmintically active compounds

Parasitology research (1987), 2002-06, Vol.88 (6), p.481-488

2002

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A γ-Lactone Form Nafuredin, Nafuredin-γ, also Inhibits Helminth Complex I

Journal of antibiotics, 2005-01, Vol.58 (1), p.50-55

2005

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Activity of the cyclic depsipeptide emodepside (BAY 44-4400) against larval and adult stages of nematodes in rodents and the influence on worm survival

Parasitology research (1987), 2001-11, Vol.87 (11), p.924-928

2001

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Synthesis and biological evaluation of novel 4″-alkoxy avermectin derivatives

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (16), p.4135-4139

2004

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Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action

Trends in parasitology, 2012-09, Vol.28 (9), p.385-394

2012

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Synthesis and biological activities of novel 4″-alkylidene avermectin derivatives

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.3943-3946

2003

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The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans

International journal for parasitology, 2007-12, Vol.37 (14), p.1577-1588

2007

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Efficacy of Cyclooctadepsipeptides and Aminophenylamidines against Larval, Immature and Mature Adult Stages of a Parasitologically Characterized Trichurosis Model in Mice: e2698

PLoS neglected tropical diseases, 2014-02, Vol.8 (2)

2014

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Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo

Parasitology, 2011-08, Vol.138 (9), p.1193-1201

2011

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Development of emodepside as a possible adulticidal treatment for human onchocerciasis—The fruit of a successful industrial–academic collaboration

Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPMPZQ by PZQ, enhanced Ca++ influx, spastic paralysis, and tegumental disrupture—the deadly cascade in parasitic schistosomes, other trematodes, and cestodes

Activation of transient receptor potential channel Sm.TRPM.sub.PZQ by PZQ, enhanced Ca.sup.++ influx, spastic paralysis, and tegumental disrupture-the deadly cascade in parasitic schistosomes, other trematodes, and cestodes

Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside

Phylogenetic characterization of β-tubulins and development of pyrosequencing assays for benzimidazole resistance in cattle nematodes

Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside

The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits

SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants

Efficacy of cyclooctadepsipeptides and aminophenylamidines against larval, immature and mature adult stages of a parasitologically characterized trichurosis model in mice

Activation of transient receptor potential channel Sm.(Schistosoma mansoni)TRPM PZQ by PZQ, enhanced Ca ++ influx, spastic paralysis, and tegumental disrupture-the deadly cascade in parasitic schistosomes, other trematodes, and cestodes

Interactions of anthelmintic drugs in Caenorhabditis elegans neuro-muscular ion channel mutants

Anthelmintic cyclooctadepsipeptides: complex in structure and mode of action

An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria

PF1022A and related cyclodepsipeptides - a novel class of anthelmintics

Praziquantel – 50 Years of Research

An Anthelmintic Compound, Nafuredin, Shows Selective Inhibition of Complex I in Helminth Mitochondria

Cyclooctadepsipeptides: a new class of anthelmintically active compounds

A γ-Lactone Form Nafuredin, Nafuredin-γ, also Inhibits Helminth Complex I

Activity of the cyclic depsipeptide emodepside (BAY 44-4400) against larval and adult stages of nematodes in rodents and the influence on worm survival

Synthesis and biological evaluation of novel 4″-alkoxy avermectin derivatives

Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action

Synthesis and biological activities of novel 4″-alkylidene avermectin derivatives

The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans

Efficacy of Cyclooctadepsipeptides and Aminophenylamidines against Larval, Immature and Mature Adult Stages of a Parasitologically Characterized Trichurosis Model in Mice: e2698

Efficacy of the cyclooctadepsipeptide PF1022A against Heligmosomoides bakeri in vitro and in vivo

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