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Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

Frontiers in oncology, 2020-01, Vol.9, p.1563-1563

2020

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Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

Nucleic acids research, 2021-07, Vol.49 (13), p.7492-7506

2021

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The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

Nature communications, 2016-07, Vol.7 (1), p.12308-12308, Article 12308

2016

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Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells

Cancer research (Chicago, Ill.), 2018-09, Vol.78 (17), p.5060-5071

2018

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Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

Molecular cell, 2013-12, Vol.52 (5), p.758-766

2013

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Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review

Biochemical Society transactions, 2021-06, Vol.49 (3), p.1251-1263

2021

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Challenges to DNA replication in hypoxic conditions

The FEBS journal, 2018-05, Vol.285 (9), p.1563-1571

2018

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Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas

International journal of radiation oncology, biology, physics, 2019-11, Vol.105 (3), p.548-558

2019

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Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter

Journal of hepatology, 2021-07, Vol.75 (1), p.64-73

2021

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Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

Cell chemical biology, 2021-09, Vol.28 (9), p.1258-1270.e13

2021

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Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment

Cancer research (Chicago, Ill.), 2010-10, Vol.70 (20), p.8045-8054

2010

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Targeting Hypoxic Cells through the DNA Damage Response

Clinical cancer research, 2010-12, Vol.16 (23), p.5624-5629

2010

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UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

Scientific reports, 2017-07, Vol.7 (1), p.6879-9, Article 6879

2017

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Hypoxia-induced SETX links replication stress with the unfolded protein response

Nature communications, 2021-06, Vol.12 (1), p.3686-14, Article 3686

2021

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Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs

Nature protocols, 2016-04, Vol.11 (4), p.781-794

2016

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Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3217-3227

2013

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Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

Cancer research (Chicago, Ill.), 2010-02, Vol.70 (3), p.925-935

2010

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Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

PloS one, 2011-01, Vol.6 (1), p.e16210-e16210

2011

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Hypoxia‐mediated regulation of DDX5 through decreased chromatin accessibility and post‐translational targeting restricts R‐loop accumulation

Molecular oncology, 2023-07, Vol.17 (7), p.1173-1191

2023

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KDM4A regulates HIF-1 levels through H3K9me3

Scientific reports, 2017-09, Vol.7 (1), p.11094-9, Article 11094

2017

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ATM Activation and Signaling under Hypoxic Conditions

Molecular and Cellular Biology, 2009-01, Vol.29 (2), p.526-537

2009

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A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells

Autophagy, 2012-04, Vol.8 (4), p.677-689

2012

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ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness

EMBO reports, 2023-01, Vol.24 (1), p.e54042-n/a

2023

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Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Redox biology, 2021-05, Vol.41, p.101885, Article 101885

2021

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Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality

International journal of radiation oncology, biology, physics, 2016-06, Vol.95 (2), p.772-781

2016

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Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia

Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review

Challenges to DNA replication in hypoxic conditions

Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas

Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter

Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor

Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment

Targeting Hypoxic Cells through the DNA Damage Response

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

Hypoxia-induced SETX links replication stress with the unfolded protein response

Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)

Hypoxia‐mediated regulation of DDX5 through decreased chromatin accessibility and post‐translational targeting restricts R‐loop accumulation

KDM4A regulates HIF-1 levels through H3K9me3

ATM Activation and Signaling under Hypoxic Conditions

A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells

ZBTB2 links p53 deficiency to HIF‐1‐mediated hypoxia signaling to promote cancer aggressiveness

Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality

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