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Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2

The Journal of pharmacology and experimental therapeutics, 2008-08, Vol.326 (2), p.443-452

2008

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Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms

Toxicological sciences, 2016-09, Vol.153 (1), p.39-54

2016

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Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: A blinded validation

Heart rhythm, 2012-10, Vol.9 (10), p.1706-1715

2012

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Translational assessment of cardiac contractility by echocardiography in the telemetered rat

Journal of pharmacological and toxicological methods, 2016-01, Vol.77, p.24-32

2016

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Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation

Frontiers in pharmacology, 2012-01, Vol.3, p.6-6

2012

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Conditional and Targeted Overexpression of Vascular Chymase Causes Hypertension in Transgenic Mice

Proceedings of the National Academy of Sciences - PNAS, 2001-06, Vol.98 (13), p.7469-7474

2001

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p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension

The Journal of pharmacology and experimental therapeutics, 2003-12, Vol.307 (3), p.932-938

2003

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Sustained activation of p38 mitogen-activated protein kinase contributes to the vascular response to injury

The Journal of pharmacology and experimental therapeutics, 2002-04, Vol.301 (1), p.15-20

2002

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The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative

Toxicological sciences, 2014-12, Vol.142 (2), p.427-435

2014

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Off-target cardiac Na-channel inhibition in preclinical and clinical development—A case study

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.354-354

2016

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Modification of the extracellular matrix following myocardial infarction monitored by FTIR spectroscopy

Biochimica et biophysica acta, 1996-03, Vol.1315 (2), p.73-77

1996

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In vitro blinded validation study in rabbit heart using isolated Purkinje fibers and wedge preparations

Journal of pharmacological and toxicological methods, 2014-11, Vol.70 (3), p.332-332

2014

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Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells

Molecular and cellular biochemistry, 2007-01, Vol.295 (1-2), p.113-120

2007

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Investigation of hemodynamic changes induced by CompoundX in Wistar Han rats

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.367-367

2016

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Decreased ejection fraction induced by a MEK inhibitor in spontaneously hypertensive and Wistar rats: Reversibility following co-administration of lisinopril

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.350-350

2016

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Compound X increases heart weight: Ultrasound and telemetry evaluation in the rat

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.174-174

2015

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Preclinical investigation of blood pressure elevation induced by DEB025 in spontaneously hypertensive rats (SHR)

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.183-183

2015

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Hypertensive rat model induced by iv infusion of phenylephrine via programmable pump

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.181-181

2015

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Application of an in vitro model for early detection of cardiac sodium channel blocking liabilities

Journal of pharmacological and toxicological methods, 2014-11, Vol.70 (3), p.330-330

2014

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Evaluation of cardiac contractility in a telemetered rat model: Compare to a translational assessment by echocardiography

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.175-175

2015

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Meaningful telemetry data can be obtained in the same animal with full TK profiling in toxicological studies

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.185-185

2012

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Acute protection of ischemic heart by FGF-2: involvement of FGF-2 receptors and protein kinase C

American journal of physiology. Heart and circulatory physiology, 2002-03, Vol.51 (3), p.1071-1080

2002

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Effect of angiotensin II on myocardial collagen gene expression

Molecular and cellular biochemistry, 1996, Vol.163-164 (1), p.231-237

1996

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Differentiating electrophysiological effects and cardiac safety of drugs based on in vitro electrocardiogram: A blinded validation

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.e23-e23

2013

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Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2

Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms

Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: A blinded validation

Translational assessment of cardiac contractility by echocardiography in the telemetered rat

Cardiac Safety Implications of hNav1.5 Blockade and a Framework for Pre-Clinical Evaluation

Conditional and Targeted Overexpression of Vascular Chymase Causes Hypertension in Transgenic Mice

p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 1. p38 MAPK-dependent endothelial dysfunction and hypertension

Sustained activation of p38 mitogen-activated protein kinase contributes to the vascular response to injury

Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation

The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative

Off-target cardiac Na-channel inhibition in preclinical and clinical development—A case study

Modification of the extracellular matrix following myocardial infarction monitored by FTIR spectroscopy

In vitro blinded validation study in rabbit heart using isolated Purkinje fibers and wedge preparations

Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells

Investigation of hemodynamic changes induced by CompoundX in Wistar Han rats

Decreased ejection fraction induced by a MEK inhibitor in spontaneously hypertensive and Wistar rats: Reversibility following co-administration of lisinopril

Compound X increases heart weight: Ultrasound and telemetry evaluation in the rat

Preclinical investigation of blood pressure elevation induced by DEB025 in spontaneously hypertensive rats (SHR)

Hypertensive rat model induced by iv infusion of phenylephrine via programmable pump

Application of an in vitro model for early detection of cardiac sodium channel blocking liabilities

Evaluation of cardiac contractility in a telemetered rat model: Compare to a translational assessment by echocardiography

Meaningful telemetry data can be obtained in the same animal with full TK profiling in toxicological studies

Acute protection of ischemic heart by FGF-2: involvement of FGF-2 receptors and protein kinase C

Effect of angiotensin II on myocardial collagen gene expression

Differentiating electrophysiological effects and cardiac safety of drugs based on in vitro electrocardiogram: A blinded validation

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