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L-Type amino acid transporter 1 as a target for drug delivery

Pharmaceutical research, 2020-05, Vol.37 (5), p.88-88, Article 88

2020

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L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

Journal of controlled release, 2017-09, Vol.261, p.93-104

2017

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The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy

Pharmaceutics, 2023-01, Vol.15 (2), p.364

2023

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L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

International journal of pharmaceutics, 2019-11, Vol.571, p.118714, Article 118714

2019

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Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

Scientific reports, 2021-06, Vol.11 (1), p.13076-13076, Article 13076

2021

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A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells

Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5740-5751

2016

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Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

Neurobiology of disease, 2022-07, Vol.169, p.105741-105741, Article 105741

2022

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Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer's disease

Frontiers in pharmacology, 2024-03, Vol.15, p.1365051-1365051

2024

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The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality

Pharmaceutical research, 2021-10, Vol.38 (10), p.1663-1675

2021

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Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

International journal of pharmaceutics, 2021-03, Vol.596, p.120300, Article 120300

2021

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Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Molecular pharmaceutics, 2019-07, Vol.16 (7), p.3261-3274

2019

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Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake

International journal of pharmaceutics, 2018-06, Vol.544 (1), p.91-99

2018

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Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

Molecular pharmaceutics, 2016-07, Vol.13 (7), p.2484-2491

2016

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Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

Neurochemical research, 2016-10, Vol.41 (10), p.2797-2809

2016

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Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery

Molecular pharmaceutics, 2011-10, Vol.8 (5), p.1857-1866

2011

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Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation

Bioorganic chemistry, 2021-07, Vol.112, p.104921, Article 104921

2021

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L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels

Pharmaceutics, 2020-04, Vol.12 (4), p.344

2020

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Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Pharmaceutics, 2022-11, Vol.14 (11), p.2438

2022

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Targeting Transporters for Drug Delivery to the Brain: Can We Do Better?

Pharmaceutical research, 2022-07, Vol.39 (7), p.1415-1455

2022

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Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3348-3353

2009

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Brain uptake of ketoprofen–lysine prodrug in rats

International journal of pharmaceutics, 2010-10, Vol.399 (1), p.121-128

2010

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Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests

Neuroscience letters, 2013-06, Vol.546, p.6-10

2013

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Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Brain disorders, 2022-06, Vol.6, p.100035, Article 100035

2022

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Targeted efflux transporter inhibitors – A solution to improve poor cellular accumulation of anti-cancer agents

International journal of pharmaceutics, 2018-10, Vol.550 (1-2), p.278-289

2018

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L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery

European journal of pharmaceutical sciences, 2019-03, Vol.129, p.99-109

2019

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L-Type amino acid transporter 1 as a target for drug delivery

L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy

L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice

A Selective and Slowly Reversible Inhibitor of l‑Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells

Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model

Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer's disease

The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality

Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

Mechanistic Study on the Use of the l‑Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake

Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery

Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation

L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels

Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease

Targeting Transporters for Drug Delivery to the Brain: Can We Do Better?

Glucose Promoiety Enables Glucose Transporter Mediated Brain Uptake of Ketoprofen and Indomethacin Prodrugs in Rats

Brain uptake of ketoprofen–lysine prodrug in rats

Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests

Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Targeted efflux transporter inhibitors – A solution to improve poor cellular accumulation of anti-cancer agents

L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery

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