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The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops

Nature communications, 2022-02, Vol.13 (1), p.654-654, Article 654

2022

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Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential

Trends in biochemical sciences (Amsterdam. Regular ed.), 2018-09, Vol.43 (9), p.700-713

2018

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From keys to bulldozers: expanding roles for winged helix domains in nucleic-acid-binding proteins

Trends in biochemical sciences (Amsterdam. Regular ed.), 2013-07, Vol.38 (7), p.364-371

2013

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Effect of allosteric inhibition of non-muscle myosin 2 on its intracellular diffusion

Scientific reports, 2020-08, Vol.10 (1), p.13341-13341, Article 13341

2020

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Shuttling along DNA and directed processing of D-loops by RecQ helicase support quality control of homologous recombination

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (4), p.E466-E475

2017

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Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues

Journal of pharmaceutical and biomedical analysis, 2021-09, Vol.204, p.114246-114246, Article 114246

2021

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RecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical coupling

Proceedings of the National Academy of Sciences - PNAS, 2012-06, Vol.109 (25), p.9804-9809

2012

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Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

Cell, 2020-10, Vol.183 (2), p.335-346.e13

2020

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Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2

The Journal of pharmacology and experimental therapeutics, 2021-03, Vol.376 (3), p.358-373

2021

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Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA

Nucleic acids research, 2010-07, Vol.38 (13), p.4404-4414

2010

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Mechanism of RecQ helicase mechanoenzymatic coupling reveals that the DNA interactions of the ADP-bound enzyme control translocation run terminations

Nucleic acids research, 2015-01, Vol.43 (2), p.1090-1097

2015

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Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke

Theranostics, 2020-01, Vol.10 (12), p.5341-5356

2020

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Recent adaptations of fluorescence techniques for the determination of mechanistic parameters of helicases and translocases

Methods (San Diego, Calif.), 2016-10, Vol.108, p.24-39

2016

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Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates

The FASEB journal, 2013-12, Vol.27 (12), p.4954-4964

2013

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Streamlined determination of processive run length and mechanochemical coupling of nucleic acid motor activities

Nucleic acids research, 2010-04, Vol.38 (7), p.e102-e102

2010

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Reversible movement of switch 1 loop of myosin determines actin interaction

The EMBO journal, 2007-01, Vol.26 (1), p.265-274

2007

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RecQ helicase triggers a binding mode change in the SSB–DNA complex to efficiently initiate DNA unwinding

Nucleic acids research, 2017-11, Vol.45 (20), p.11878-11890

2017

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Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state

Nucleic acids research, 2018-05, Vol.46 (8), p.3967-3980

2018

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Kinetic Characterization of the Function of Myosin Loop 4 in the Actin−Myosin Interaction

Biochemistry (Easton), 2008-01, Vol.47 (1), p.283-291

2008

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Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains

Nucleic acids research, 2012-05, Vol.40 (9), p.3952-3963

2012

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Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (15), p.6799-6804

2010

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Abstract P217: Direct Myosin-2 Inhibition Restores Cerebral Perfusion in Cortical and Subcortical Regions Resulting in Functional Improvement After Ischemic Stroke

Stroke (1970), 2021-03, Vol.52 (Suppl_1)

2021

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Skeletal muscle myosin inhibition by MPH-220 reduces seizure severity in epilepsy rat model

Biophysical journal, 2022-02, Vol.121 (3), p.513a-514a

2022

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RECQ Helicase Triggers a Binding Mode Change in the SSB-DNA Complex Efficiently Initiate DNA Unwinding

Biophysical journal, 2018-02, Vol.114 (3), p.218a-218a

2018

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The Mechanism of the Reverse Recovery Step, Phosphate Release, and Actin Activation of Dictyostelium Myosin II

The Journal of biological chemistry, 2008-03, Vol.283 (13), p.8153-8163

2008

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The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops

Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological Potential

From keys to bulldozers: expanding roles for winged helix domains in nucleic-acid-binding proteins

Effect of allosteric inhibition of non-muscle myosin 2 on its intracellular diffusion

Shuttling along DNA and directed processing of D-loops by RecQ helicase support quality control of homologous recombination

Chiral HPLC separation of enantiomeric blebbistatin derivatives and racemization analysis in vertebrate tissues

RecQ helicase translocates along single-stranded DNA with a moderate processivity and tight mechanochemical coupling

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

Improved Inhibitory and Absorption, Distribution, Metabolism, Excretion, and Toxicology (ADMET) Properties of Blebbistatin Derivatives Indicate That Blebbistatin Scaffold Is Ideal for drug Development Targeting Myosin-2

Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA

Mechanism of RecQ helicase mechanoenzymatic coupling reveals that the DNA interactions of the ADP-bound enzyme control translocation run terminations

Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke

Recent adaptations of fluorescence techniques for the determination of mechanistic parameters of helicases and translocases

Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates

Streamlined determination of processive run length and mechanochemical coupling of nucleic acid motor activities

Reversible movement of switch 1 loop of myosin determines actin interaction

RecQ helicase triggers a binding mode change in the SSB–DNA complex to efficiently initiate DNA unwinding

Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state

Kinetic Characterization of the Function of Myosin Loop 4 in the Actin−Myosin Interaction

Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains

Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke

Abstract P217: Direct Myosin-2 Inhibition Restores Cerebral Perfusion in Cortical and Subcortical Regions Resulting in Functional Improvement After Ischemic Stroke

Skeletal muscle myosin inhibition by MPH-220 reduces seizure severity in epilepsy rat model

RECQ Helicase Triggers a Binding Mode Change in the SSB-DNA Complex Efficiently Initiate DNA Unwinding

The Mechanism of the Reverse Recovery Step, Phosphate Release, and Actin Activation of Dictyostelium Myosin II

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