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Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin

ACS medicinal chemistry letters, 2017-03, Vol.8 (3), p.321-326

2017

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Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2297-2300

2007

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Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (12), p.2678-2682

2017

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Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV

Journal of medicinal chemistry, 2011-01, Vol.54 (2), p.510-524

2011

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Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6628-6631

2012

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Design, synthesis and SAR of novel glucokinase activators

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.2166-2171

2013

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Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.465-469

2002

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Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine Proteases

Journal of the American Chemical Society, 1998-10, Vol.120 (42), p.10994-10995

1998

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Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (7), p.2362-2367

2008

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Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2293-2298

2006

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A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models

Molecular cancer therapeutics, 2024-01, Vol.23 (1), p.3-13

2024

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Discovery of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors

Bioorganic & medicinal chemistry, 2007-04, Vol.15 (7), p.2759-2767

2007

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Biological Activity of A-289099: An Orally Active Tubulin-binding Indolyloxazoline Derivative

Molecular cancer therapeutics, 2003-03, Vol.2 (3), p.227-233

2003

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Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4001-4005

2003

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Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1359-1362

2003

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Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

Molecular and biochemical parasitology, 2001-11, Vol.118 (1), p.61-73

2001

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Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase IV

Current topics in medicinal chemistry, 2008-11, Vol.8 (17), p.1545-1552

Gwaltney, 2nd, Stephen L

2008

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Current approaches to the treatment of diabetes

Current topics in medicinal chemistry, 2008-11, Vol.8 (17), p.1482

Gwaltney, 2nd, Stephen L

2008

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Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (21), p.5371-5376

2004

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Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1363-1366

2003

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Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Journal of medicinal chemistry, 2008-07, Vol.51 (14), p.4357-4357

2008

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Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents

Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (7), p.871-874

2001

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Novel sulfonate Derivatives: potent antimitotic agents

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1671-1673

2001

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Abstract 3945: Novel antagonists of TEAD palmitoylation inhibit the growth of Hippo-altered cancers in preclinical models

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3945-3945

2022

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Stereoselective synthesis of an advanced taxusin intermediate: an application of the type 2 intramolecular Diels–Alder reaction

Tetrahedron letters, 2003-12, Vol.44 (52), p.9379-9382

2003

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Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin

Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators

Design and Synthesis of Pyrimidinone and Pyrimidinedione Inhibitors of Dipeptidyl Peptidase IV

Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors

Design, synthesis and SAR of novel glucokinase activators

Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent

Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine Proteases

Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors

A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models

Discovery of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors

Biological Activity of A-289099: An Orally Active Tubulin-binding Indolyloxazoline Derivative

Pyridone-Containing farnesyltransferase inhibitors: synthesis and biological evaluation

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase IV

Current approaches to the treatment of diabetes

Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors

Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency

Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV

Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents

Novel sulfonate Derivatives: potent antimitotic agents

Abstract 3945: Novel antagonists of TEAD palmitoylation inhibit the growth of Hippo-altered cancers in preclinical models

Stereoselective synthesis of an advanced taxusin intermediate: an application of the type 2 intramolecular Diels–Alder reaction

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