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Regulation of a Xenobiotic Sulfonation Cascade by Nuclear Pregnane X Receptor (PXR)

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (21), p.13801-13806

2002

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Humanized xenobiotic response in mice expressing nuclear receptor SXR

Nature (London), 2000-07, Vol.406 (6794), p.435-439

2000

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Evidence-based toxicology: a comprehensive framework for causation

Human & experimental toxicology, 2005-04, Vol.24 (4), p.161-201

2005

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Cyp3A regulation: from pharmacology to nuclear receptors

Drug metabolism and disposition, 2001-05, Vol.29 (5), p.615

2001

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

Genes & development, 2000-12, Vol.14 (23), p.3014-3023

2000

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Identification of Genes Controlled by the Pregnane X Receptor by Microarray Analysis of mRNAs from Pregnenolone 16α-Carbonitrile–Treated Rats

Toxicological sciences, 2006-12, Vol.94 (2), p.379-387

2006

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Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

Biochemistry (Easton), 1985-04, Vol.24 (9), p.2171-2178

1985

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Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase

Biochemistry (Easton), 1990-01, Vol.29 (4), p.1080-1087

1990

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Regulation of human liver cytochromes P‐450 in family 3A in primary and continuous culture of human hepatocytes

Hepatology (Baltimore, Md.), 1993-11, Vol.18 (5), p.1254-1262

1993

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Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

Journal of cellular physiology, 1988-03, Vol.134 (3), p.309-323

1988

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A Novel cis-Acting Element in a Liver Cytochrome P450 3A Gene Confers Synergistic Induction by Glucocorticoids plus Antiglucocorticoids

The Journal of biological chemistry, 1995-12, Vol.270 (48), p.28917-28923

1995

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Collagen Formation by the Hepatocyte in Primary Monolayer Culture and in vivo

Science (American Association for the Advancement of Science), 1983-03, Vol.219 (4590), p.1343-1345

1983

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Ectopic expression of MHC class II genes (RT1.B(I) β/α) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16α-carbonitrile and dexamethasone

Life sciences (1973), 2002-06, Vol.71 (3), p.311-323

2002

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Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel

Biochemical pharmacology, 1994-11, Vol.48 (9), p.1815-1822

1994

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Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes

Cancer research (Chicago, Ill.), 1990-09, Vol.50 (17), p.5219-5224

1990

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Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo

Biochemistry (Easton), 1986-03, Vol.25 (5), p.1124-1133

1986

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Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats

Toxicological sciences, 2006-12, Vol.94 (2), p.379

2006

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Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes

Molecular pharmacology, 1996-07, Vol.50 (1), p.10

1996

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Drug metabolism in adult rat hepatocytes in primary monolayer culture

Gastroenterology (New York, N.Y. 1943), 1977-06, Vol.72 (6), p.1232-1239

1977

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Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

Pharmacogenetics (London), 1994-02, Vol.4 (1), p.11-20

1994

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Clinical Evaluation of Liver Structure and Function in Humans Exposed to Halogenated Hydrocarbons

Environmental health perspectives, 1985-05, Vol.60, p.159-164

Guzelian, Philip S.

1985

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Treatment of chlordecone (Kepone) toxicity with cholestyramine. Results of a controlled clinical trial

The New England journal of medicine, 1978-02, Vol.298 (5), p.243-248

1978

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Five of 12 Forms of Vaccinia Virus-Expressed Human Hepatic Cytochrome P450 Metabolically Activate Aflatoxin B1

Proceedings of the National Academy of Sciences - PNAS, 1990-06, Vol.87 (12), p.4790-4793

1990

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Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells

Molecular pharmacology, 1996-01, Vol.49 (1), p.63-72

1996

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Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta

The Journal of clinical investigation, 1993-08, Vol.92 (2), p.1018-1024

1993

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Regulation of a Xenobiotic Sulfonation Cascade by Nuclear Pregnane X Receptor (PXR)

Humanized xenobiotic response in mice expressing nuclear receptor SXR

Evidence-based toxicology: a comprehensive framework for causation

Cyp3A regulation: from pharmacology to nuclear receptors

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

Identification of Genes Controlled by the Pregnane X Receptor by Microarray Analysis of mRNAs from Pregnenolone 16α-Carbonitrile–Treated Rats

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase

Regulation of human liver cytochromes P‐450 in family 3A in primary and continuous culture of human hepatocytes

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

A Novel cis-Acting Element in a Liver Cytochrome P450 3A Gene Confers Synergistic Induction by Glucocorticoids plus Antiglucocorticoids

Collagen Formation by the Hepatocyte in Primary Monolayer Culture and in vivo

Ectopic expression of MHC class II genes (RT1.B(I) β/α) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16α-carbonitrile and dexamethasone

Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel

Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes

Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo

Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats

Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes

Drug metabolism in adult rat hepatocytes in primary monolayer culture

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

Clinical Evaluation of Liver Structure and Function in Humans Exposed to Halogenated Hydrocarbons

Treatment of chlordecone (Kepone) toxicity with cholestyramine. Results of a controlled clinical trial

Five of 12 Forms of Vaccinia Virus-Expressed Human Hepatic Cytochrome P450 Metabolically Activate Aflatoxin B1

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells

Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta

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