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Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes

PloS one, 2019-09, Vol.14 (9), p.e0221763-e0221763

2019

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Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Frontiers in pharmacology, 2019-08, Vol.10, p.934-934

2019

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Comparison of Physiological Parameters and Anaesthesia Specific Observations during Isoflurane, Ketamine-Xylazine or Medetomidine-Midazolam-Fentanyl Anaesthesia in Male Guinea Pigs

PloS one, 2016-09, Vol.11 (9), p.e0161258-e0161258

2016

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Preclinical Cardiovascular Risk Assessment in Modern Drug Development

Toxicological sciences, 2007-05, Vol.97 (1), p.4-20

Guth, Brian D.

2007

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Effects of isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl on physiological variables continuously measured by telemetry in Wistar rats

BMC veterinary research, 2014-08, Vol.10 (1), p.198-198, Article 198

2014

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Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters

PloS one, 2017-03, Vol.12 (3), p.e0174423-e0174423

2017

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The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies

Journal of pharmacological and toxicological methods, 2023-05, Vol.121, p.107263-107263, Article 107263

2023

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Safety pharmacology in and for Africa: Establishment of the pre-clinical drug development platform

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.26-28

2018

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Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

Journal of pharmacological and toxicological methods, 2023-07, Vol.122, p.107279-107279, Article 107279

2023

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Optimization of bioanalysis of dried blood samples

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107296-107296, Article 107296

2023

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A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.90-97

2018

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Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection

Journal of pharmacological and toxicological methods, 2016-11, Vol.82, p.74-82

2016

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Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Frontiers in pharmacology, 2019-08, Vol.10, p.884-884

2019

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The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.70-90

2015

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An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.91-100

2015

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GLP in safety pharmacology studies: Report card after 15years

Journal of pharmacological and toxicological methods, 2017-09, Vol.87, p.24-26

2017

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Solubility assessment and on-line exposure confirmation in a patch-clamp assay for hERG (human ether-a-go-go-related gene) potassium channel inhibition

Journal of pharmacological and toxicological methods, 2014-09, Vol.70 (2), p.182-187

2014

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INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106889-106889, Article 106889

2020

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Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa

Journal of pharmacological and toxicological methods, 2019-07, Vol.98, p.106579, Article 106579

2019

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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs

Journal of pharmacological and toxicological methods, 2018-07, Vol.92, p.43-51

2018

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Evaluation of cardiovascular and ECG parameters in the normal, freely moving Göttingen Minipig

Journal of pharmacological and toxicological methods, 2008-05, Vol.57 (3), p.202-211

2008

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Developing a strategy for the nonclinical assessment of proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization

Journal of pharmacological and toxicological methods, 2004-05, Vol.49 (3), p.159-169

2004

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Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1

American journal of physiology. Heart and circulatory physiology, 2003-04, Vol.284 (4), p.H1422-H1428

2003

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Effect of commonly used vehicles on gastrointestinal, renal, and liver function in rats

Journal of pharmacological and toxicological methods, 2006-09, Vol.54 (2), p.200-214

2006

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Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Comparison of Physiological Parameters and Anaesthesia Specific Observations during Isoflurane, Ketamine-Xylazine or Medetomidine-Midazolam-Fentanyl Anaesthesia in Male Guinea Pigs

Preclinical Cardiovascular Risk Assessment in Modern Drug Development

Effects of isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl on physiological variables continuously measured by telemetry in Wistar rats

Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters

The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies

Safety pharmacology in and for Africa: Establishment of the pre-clinical drug development platform

Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization

Optimization of bioanalysis of dried blood samples

A new telemetry-based system for assessing cardiovascular function in group-housed large animals. Taking the 3Rs to a new level with the evaluation of remote measurement via cloud data transmission

Influence of field potential duration on spontaneous beating rate of human induced pluripotent stem cell-derived cardiomyocytes: Implications for data analysis and test system selection

Considerations for an In Vitro , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium

An integrated platform for simultaneous multi-well field potential recording and Fura-2-based calcium transient ratiometry in human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes

GLP in safety pharmacology studies: Report card after 15years

Solubility assessment and on-line exposure confirmation in a patch-clamp assay for hERG (human ether-a-go-go-related gene) potassium channel inhibition

Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium

INSPIRE: A European training network to foster research and training in cardiovascular safety pharmacology

Drug safety Africa: An overview of safety pharmacology & toxicology in South Africa

The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs

Evaluation of cardiovascular and ECG parameters in the normal, freely moving Göttingen Minipig

Developing a strategy for the nonclinical assessment of proarrhythmic risk of pharmaceuticals due to prolonged ventricular repolarization

Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1

Effect of commonly used vehicles on gastrointestinal, renal, and liver function in rats

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