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Dealing with hERG liabilities early: diverse approaches to an important goal in drug development

British journal of pharmacology, 2010-01, Vol.159 (1), p.22-24

2010

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Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.107-116

2009

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Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1

American journal of physiology. Heart and circulatory physiology, 2003-04, Vol.284 (4), p.H1422-H1428

2003

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Measurement of regional myocardial blood flow with multiple colored microspheres

Circulation (New York, N.Y.), 1991-03, Vol.83 (3), p.974-982

1991

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Recruitment of an Inotropic Reserve in Moderately Ischemic Myocardium at the Expense of Metabolic Recovery: A Model of Short-term Hibernation

Circulation research, 1992-06, Vol.70 (6), p.1282-1295

1992

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Time course and mechanisms of contractile dysfunction during acute myocardial ischemia

Circulation (New York, N.Y.), 1993-05, Vol.87 (5 Suppl), p.IV35-IV42

1993

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No effect of coronary perfusion on regional myocardial function within the autoregulatory range in pigs : evidence against the Gregg phenomenon

Circulation (New York, N.Y.), 1991-04, Vol.83 (4), p.1390-1403

1991

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Influence of the force-frequency relation on left ventricular function during exercise in conscious dogs

Circulation (New York, N.Y.), 1992-08, Vol.86 (2), p.563-571

1992

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Impact of α-Adrenergic Coronary Vasoconstriction on the Transmural Myocardial Blood Flow Distribution During Humoral and Neuronal Adrenergic Activation

Circulation research, 1993-11, Vol.73 (5), p.869-886

1993

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Consequences of Regional Inotropic Stimulation of Ischemic Myocardium on Regional Myocardial Blood Flow and Function in Anesthetized Swine

Circulation research, 1989-06, Vol.64 (6), p.1116-1136

1989

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Intracoronary alpha 2-adrenergic receptor blockade attenuates ischemia in conscious dogs during exercise

Circulation research, 1988-03, Vol.62 (3), p.436-442

1988

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Mechanisms of improved ischemic regional dysfunction by bradycardia. Studies on UL-FS 49 in swine

Circulation (New York, N.Y.), 1989-10, Vol.80 (4), p.983-993

1989

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Mechanism of Beneficial Effect of β-Adrenergic Blockade on Exercise-Induced Myocardial Ischemia in Conscious Dogs

Circulation research, 1987-05, Vol.60 (5), p.738-746

1987

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Heart rate and force-frequency effects on diastolic function of the left ventricle in exercising dogs

Circulation (New York, N.Y.), 1994-05, Vol.89 (5), p.2361-2368

1994

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Elimination of exercise-induced regional myocardial dysfunction by a bradycardiac agent in dogs with chronic coronary stenosis

Circulation (New York, N.Y.), 1987-03, Vol.75 (3), p.661-669

1987

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Effects of the specific bradycardic agent zatebradine on hemodynamic variables and myocardial blood flow during the early postresuscitation phase in pigs

Resuscitation, 1999-11, Vol.42 (3), p.211-220

1999

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Myocardial lactate release during ischemia in swine : relation to regional blood flow

Circulation (New York, N.Y.), 1990-06, Vol.81 (6), p.1948-1958

1990

Volltextzugriff (PDF)

DTTX30, a combined thromboxane receptor antagonist and thromboxane synthetase inhibitor, prevents coronary thrombosis in anesthetized dogs

Basic research in cardiology, 1997-06, Vol.92 (3), p.181-190

1997

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Antagonism of the GPIIb/IIIa Receptor with the Nonpeptidic Molecule BIBU52: Inhibition of Platelet Aggregation In Vitro and Antithrombotic Efficacy In Vivo

Journal of cardiovascular pharmacology, 1997-08, Vol.30 (2), p.261-272

1997

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Ischemia of the Dog Heart Induces the Appearance of a Cardiac mRNA Coding for a Protein with Migration Characteristics Similar to Heat-Shock/Stress Protein 71

Circulation research, 1986-07, Vol.59 (1), p.110-114

1986

Volltextzugriff (PDF)

Changes of left ventricular diastolic function in exercising dogs without and with ischemia

Circulation (New York, N.Y.), 1990-03, Vol.81 (3), p.1058-1070

1990

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Attenuation of exercise-induced myocardial ischemia in dogs with recruitment of coronary vasodilator reserve by nifedipine

Circulation (New York, N.Y.), 1987-02, Vol.75 (2), p.482-490

1987

Volltextzugriff (PDF)

Regional myocardial blood flow, function and metabolism using phosphorus-31 nuclear magnetic resonance spectroscopy during ischemia and reperfusion in dogs

Journal of the American College of Cardiology, 1987-09, Vol.10 (3), p.673-681

1987

Volltextzugriff (PDF)

Increased afterload intensifies asynchronous wall motion and impairs ventricular relaxation

Journal of applied physiology (1985), 1993-07, Vol.75 (1), p.389

1993

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Dealing with hERG liabilities early: diverse approaches to an important goal in drug development

Considerations for assessing the potential effects of antidiabetes drugs on cardiac ventricular repolarization: A report from the Cardiac Safety Research Consortium

Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies

Modulation of collateral artery growth in a porcine hindlimb ligation model using MCP-1

Measurement of regional myocardial blood flow with multiple colored microspheres

Recruitment of an Inotropic Reserve in Moderately Ischemic Myocardium at the Expense of Metabolic Recovery: A Model of Short-term Hibernation

Time course and mechanisms of contractile dysfunction during acute myocardial ischemia

No effect of coronary perfusion on regional myocardial function within the autoregulatory range in pigs : evidence against the Gregg phenomenon

Influence of the force-frequency relation on left ventricular function during exercise in conscious dogs

Impact of α-Adrenergic Coronary Vasoconstriction on the Transmural Myocardial Blood Flow Distribution During Humoral and Neuronal Adrenergic Activation

Consequences of Regional Inotropic Stimulation of Ischemic Myocardium on Regional Myocardial Blood Flow and Function in Anesthetized Swine

Intracoronary alpha 2-adrenergic receptor blockade attenuates ischemia in conscious dogs during exercise

Mechanisms of improved ischemic regional dysfunction by bradycardia. Studies on UL-FS 49 in swine

Mechanism of Beneficial Effect of β-Adrenergic Blockade on Exercise-Induced Myocardial Ischemia in Conscious Dogs

Heart rate and force-frequency effects on diastolic function of the left ventricle in exercising dogs

Elimination of exercise-induced regional myocardial dysfunction by a bradycardiac agent in dogs with chronic coronary stenosis

Effects of the specific bradycardic agent zatebradine on hemodynamic variables and myocardial blood flow during the early postresuscitation phase in pigs

Myocardial lactate release during ischemia in swine : relation to regional blood flow

DTTX30, a combined thromboxane receptor antagonist and thromboxane synthetase inhibitor, prevents coronary thrombosis in anesthetized dogs

Antagonism of the GPIIb/IIIa Receptor with the Nonpeptidic Molecule BIBU52: Inhibition of Platelet Aggregation In Vitro and Antithrombotic Efficacy In Vivo

Ischemia of the Dog Heart Induces the Appearance of a Cardiac mRNA Coding for a Protein with Migration Characteristics Similar to Heat-Shock/Stress Protein 71

Changes of left ventricular diastolic function in exercising dogs without and with ischemia

Attenuation of exercise-induced myocardial ischemia in dogs with recruitment of coronary vasodilator reserve by nifedipine

Regional myocardial blood flow, function and metabolism using phosphorus-31 nuclear magnetic resonance spectroscopy during ischemia and reperfusion in dogs

Increased afterload intensifies asynchronous wall motion and impairs ventricular relaxation

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