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Dealing with hERG liabilities early: diverse approaches to an important goal in drug development

British journal of pharmacology, 2010-01, Vol.159 (1), p.22-24

2010

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Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.107-116

2009

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Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: Current recommendations from the Safety Pharmacology Society

Journal of pharmacological and toxicological methods, 2012-05, Vol.65 (3), p.93-101

2012

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Recruitment of an Inotropic Reserve in Moderately Ischemic Myocardium at the Expense of Metabolic Recovery: A Model of Short-term Hibernation

Circulation research, 1992-06, Vol.70 (6), p.1282-1295

1992

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Measurement of regional myocardial blood flow with multiple colored microspheres

Circulation (New York, N.Y.), 1991-03, Vol.83 (3), p.974-982

1991

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Preclinical Cardiovascular Risk Assessment in Modern Drug Development

Toxicological sciences, 2007-05, Vol.97 (1), p.4-20

Guth, Brian D

2007

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Mechanism of Beneficial Effect of β-Adrenergic Blockade on Exercise-Induced Myocardial Ischemia in Conscious Dogs

Circulation research, 1987-05, Vol.60 (5), p.738-746

1987

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Heart rate and force-frequency effects on diastolic function of the left ventricle in exercising dogs

Circulation (New York, N.Y.), 1994-05, Vol.89 (5), p.2361-2368

1994

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Consequences of Regional Inotropic Stimulation of Ischemic Myocardium on Regional Myocardial Blood Flow and Function in Anesthetized Swine

Circulation research, 1989-06, Vol.64 (6), p.1116-1136

1989

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Mechanisms of improved ischemic regional dysfunction by bradycardia. Studies on UL-FS 49 in swine

Circulation (New York, N.Y.), 1989-10, Vol.80 (4), p.983-993

1989

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Myocardial lactate release during ischemia in swine : relation to regional blood flow

Circulation (New York, N.Y.), 1990-06, Vol.81 (6), p.1948-1958

1990

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Elimination of exercise-induced regional myocardial dysfunction by a bradycardiac agent in dogs with chronic coronary stenosis

Circulation (New York, N.Y.), 1987-03, Vol.75 (3), p.661-669

1987

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No effect of coronary perfusion on regional myocardial function within the autoregulatory range in pigs : evidence against the Gregg phenomenon

Circulation (New York, N.Y.), 1991-04, Vol.83 (4), p.1390-1403

1991

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Influence of the force-frequency relation on left ventricular function during exercise in conscious dogs

Circulation (New York, N.Y.), 1992-08, Vol.86 (2), p.563-571

1992

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Increased afterload intensifies asynchronous wall motion and impairs ventricular relaxation

Journal of applied physiology (1985), 1993-07, Vol.75 (1), p.389

1993

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Attenuation of exercise-induced myocardial ischemia in dogs with recruitment of coronary vasodilator reserve by nifedipine

Circulation (New York, N.Y.), 1987-02, Vol.75 (2), p.482-490

1987

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Guanidine Derivatives as Combined Thromboxane A2 Receptor Antagonists and Synthase Inhibitors

Journal of medicinal chemistry, 1999-04, Vol.42 (7), p.1235-1249

1999

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Effects of the specific bradycardic agent zatebradine on hemodynamic variables and myocardial blood flow during the early postresuscitation phase in pigs

Resuscitation, 1999-11, Vol.42 (3), p.211-220

1999

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DTTX30, a combined thromboxane receptor antagonist and thromboxane synthetase inhibitor, prevents coronary thrombosis in anesthetized dogs

Basic research in cardiology, 1997-06, Vol.92 (3), p.181-190

1997

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Changes in regional myocardial function and external work in exercising dogs with ischemia

American journal of physiology. Heart and circulatory physiology, 1993-01, Vol.264 (1), p.H110-H116

1993

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Effect of coronary hyperperfusion on regional myocardial function and oxygen consumption of stunned myocardium in pigs

Basic research in cardiology, 1991-11, Vol.86 (6), p.534-543

1991

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Antagonism of the GPIIb/IIIa Receptor with the Nonpeptidic Molecule BIBU52: Inhibition of Platelet Aggregation In Vitro and Antithrombotic Efficacy In Vivo

Journal of cardiovascular pharmacology, 1997-08, Vol.30 (2), p.261-272

1997

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Characteristics of regional myocardial stunning after exercise in dogs with chronic coronary stenosis

American journal of physiology. Heart and circulatory physiology, 1989-07, Vol.257 (1), p.H113-H119

1989

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Ischemia of the Dog Heart Induces the Appearance of a Cardiac mRNA Coding for a Protein with Migration Characteristics Similar to Heat-Shock/Stress Protein 71

Circulation research, 1986-07, Vol.59 (1), p.110-114

1986

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Dealing with hERG liabilities early: diverse approaches to an important goal in drug development : QT Safety

British journal of pharmacology, 2010, Vol.159 (1), p.22-24

2010

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Dealing with hERG liabilities early: diverse approaches to an important goal in drug development

Comparison of electrocardiographic analysis for risk of QT interval prolongation using safety pharmacology and toxicological studies

Best practice in the conduct of key nonclinical cardiovascular assessments in drug development: Current recommendations from the Safety Pharmacology Society

Recruitment of an Inotropic Reserve in Moderately Ischemic Myocardium at the Expense of Metabolic Recovery: A Model of Short-term Hibernation

Measurement of regional myocardial blood flow with multiple colored microspheres

Preclinical Cardiovascular Risk Assessment in Modern Drug Development

Mechanism of Beneficial Effect of β-Adrenergic Blockade on Exercise-Induced Myocardial Ischemia in Conscious Dogs

Heart rate and force-frequency effects on diastolic function of the left ventricle in exercising dogs

Consequences of Regional Inotropic Stimulation of Ischemic Myocardium on Regional Myocardial Blood Flow and Function in Anesthetized Swine

Mechanisms of improved ischemic regional dysfunction by bradycardia. Studies on UL-FS 49 in swine

Myocardial lactate release during ischemia in swine : relation to regional blood flow

Elimination of exercise-induced regional myocardial dysfunction by a bradycardiac agent in dogs with chronic coronary stenosis

No effect of coronary perfusion on regional myocardial function within the autoregulatory range in pigs : evidence against the Gregg phenomenon

Influence of the force-frequency relation on left ventricular function during exercise in conscious dogs

Increased afterload intensifies asynchronous wall motion and impairs ventricular relaxation

Attenuation of exercise-induced myocardial ischemia in dogs with recruitment of coronary vasodilator reserve by nifedipine

Guanidine Derivatives as Combined Thromboxane A2 Receptor Antagonists and Synthase Inhibitors

Effects of the specific bradycardic agent zatebradine on hemodynamic variables and myocardial blood flow during the early postresuscitation phase in pigs

DTTX30, a combined thromboxane receptor antagonist and thromboxane synthetase inhibitor, prevents coronary thrombosis in anesthetized dogs

Changes in regional myocardial function and external work in exercising dogs with ischemia

Effect of coronary hyperperfusion on regional myocardial function and oxygen consumption of stunned myocardium in pigs

Antagonism of the GPIIb/IIIa Receptor with the Nonpeptidic Molecule BIBU52: Inhibition of Platelet Aggregation In Vitro and Antithrombotic Efficacy In Vivo

Characteristics of regional myocardial stunning after exercise in dogs with chronic coronary stenosis

Ischemia of the Dog Heart Induces the Appearance of a Cardiac mRNA Coding for a Protein with Migration Characteristics Similar to Heat-Shock/Stress Protein 71

Dealing with hERG liabilities early: diverse approaches to an important goal in drug development : QT Safety

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