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Atropisomerism in medicinal chemistry: challenges and opportunities

Future medicinal chemistry, 2018-02, Vol.10 (4), p.409-422

2018

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Catalytic Atroposelective Synthesis of N‑Aryl Quinoid Compounds

Journal of the American Chemical Society, 2020-02, Vol.142 (5), p.2198-2203

2020

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Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination

Science (American Association for the Advancement of Science), 2010-06, Vol.328 (5983), p.1251-1255

2010

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A Practical Lewis Base Catalyzed Electrophilic Chlorination of Arenes and Heterocycles

Organic letters, 2015-02, Vol.17 (4), p.1042-1045

2015

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Lewis Base/Bronsted Acid Dual-Catalytic C–H Sulfenylation of Aromatics

Organic letters, 2018-06, Vol.20 (11), p.3211-3214

2018

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Approaches toward Atropisomerically Stable and Conformationally Pure Diarylamines

Journal of organic chemistry, 2022-05, Vol.87 (10), p.6760-6768

2022

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Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

Angewandte Chemie (International ed.), 2015-08, Vol.54 (33), p.9659-9662

International ed. in English, 2015

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The Catalyst-Controlled Regiodivergent Chlorination of Phenols

Organic letters, 2016-11, Vol.18 (21), p.5476-5479

2016

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Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst

Journal of organic chemistry, 2020-11, Vol.85 (21), p.13895-13905

2020

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Atropisomerism in the Pharmaceutically Relevant Realm

Accounts of chemical research, 2022-10, Vol.55 (20), p.2904-2919

2022

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Catalysis by electrons and holes: formal potential scales and preparative organic electrochemistry

Organic Chemistry Frontiers, 2015-01, Vol.2 (7), p.823-848

2015

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Linear Free-Energy Relationship Analysis of a Catalytic Desymmetrization Reaction of a Diarylmethane-bis(phenol)

Organic letters, 2010-06, Vol.12 (12), p.2794-2797

2010

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Synthesis of Atropisomerically Defined, Highly Substituted Biaryl Scaffolds through Catalytic Enantioselective Bromination and Regioselective Cross-Coupling

Angewandte Chemie (International ed.), 2011-05, Vol.50 (22), p.5125-5129

International ed. in English, 2011

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Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

Chembiochem : a European journal of chemical biology, 2012-03, Vol.13 (4), p.538-541

2012

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A Case of Remote Asymmetric Induction in the Peptide-Catalyzed Desymmetrization of a Bis(phenol)

Journal of the American Chemical Society, 2008-12, Vol.130 (48), p.16358-16365

2008

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Catalytic in vivo protein knockdown by small-molecule PROTACs

Nature chemical biology, 2015-08, Vol.11 (8), p.611-617

2015

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HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

ACS chemical biology, 2015-08, Vol.10 (8), p.1831-1837

2015

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Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation

ACS chemical biology, 2017-10, Vol.12 (10), p.2570-2578

2017

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Targeting the RET tyrosine kinase in neuroblastoma: A review and application of a novel selective drug design strategy

Biochemical pharmacology, 2023-10, Vol.216, p.115751-115751, Article 115751

2023

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Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

Angewandte Chemie (International ed.), 2012-11, Vol.51 (46), p.11463-11467

2012

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Redox-Responsive H‑Bonding: Amplifying the Effect of Electron Transfer Using Proton-Coupled Electron Transfer

Journal of the American Chemical Society, 2020-10, Vol.142 (41), p.17271-17276

2020

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Catalytic atroposelective dynamic kinetic resolutions and kinetic resolutions towards 3-arylquinolines via SNAr

Chemical communications (Cambridge, England), 2021-09, Vol.57 (78), p.10087-10090

2021

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Leveraging conformational control about a potential atropisomeric axis as a strategy in medical chemistry

Future medicinal chemistry, 2021-03, Vol.13 (5), p.443-446

2021

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Enantioselective Synthesis of Pyrrolopyrimidine Scaffolds through Cation-Directed Nucleophilic Aromatic Substitution

Organic letters, 2018-04, Vol.20 (7), p.2037-2041

2018

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Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors

Angewandte Chemie (International ed.), 2015-09, Vol.54 (40), p.11754-11759

International ed. in English, 2015

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Atropisomerism in medicinal chemistry: challenges and opportunities

Catalytic Atroposelective Synthesis of N‑Aryl Quinoid Compounds

Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination

A Practical Lewis Base Catalyzed Electrophilic Chlorination of Arenes and Heterocycles

Lewis Base/Bronsted Acid Dual-Catalytic C–H Sulfenylation of Aromatics

Approaches toward Atropisomerically Stable and Conformationally Pure Diarylamines

Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

The Catalyst-Controlled Regiodivergent Chlorination of Phenols

Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst

Atropisomerism in the Pharmaceutically Relevant Realm

Catalysis by electrons and holes: formal potential scales and preparative organic electrochemistry

Linear Free-Energy Relationship Analysis of a Catalytic Desymmetrization Reaction of a Diarylmethane-bis(phenol)

Synthesis of Atropisomerically Defined, Highly Substituted Biaryl Scaffolds through Catalytic Enantioselective Bromination and Regioselective Cross-Coupling

Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

A Case of Remote Asymmetric Induction in the Peptide-Catalyzed Desymmetrization of a Bis(phenol)

Catalytic in vivo protein knockdown by small-molecule PROTACs

HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation

Targeting the RET tyrosine kinase in neuroblastoma: A review and application of a novel selective drug design strategy

Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

Redox-Responsive H‑Bonding: Amplifying the Effect of Electron Transfer Using Proton-Coupled Electron Transfer

Catalytic atroposelective dynamic kinetic resolutions and kinetic resolutions towards 3-arylquinolines via SNAr

Leveraging conformational control about a potential atropisomeric axis as a strategy in medical chemistry

Enantioselective Synthesis of Pyrrolopyrimidine Scaffolds through Cation-Directed Nucleophilic Aromatic Substitution

Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors

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