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Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation

The Journal of pharmacology and experimental therapeutics, 2018-06, Vol.365 (3), p.447-459

2018

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Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells

Frontiers in pharmacology, 2021-08, Vol.12, p.725136-725136

2021

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Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma

Autophagy, 2014-08, Vol.10 (8), p.1415-1425

2014

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Identifying the ErbB/MAPK Signaling Cascade as a Therapeutic Target in Canine Bladder Cancer

Molecular pharmacology, 2019-07, Vol.96 (1), p.36-46

2019

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Predicting chemosensitivity using drug perturbed gene dynamics

BMC bioinformatics, 2021-01, Vol.22 (1), p.15-18, Article 15

2021

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Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics

Drug metabolism and disposition, 2019-03, Vol.47 (3), p.257-268

2019

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The efficacy and safety of cannabidiol as adjunct treatment for drug‐resistant idiopathic epilepsy in 51 dogs: A double‐blinded crossover study

Journal of veterinary internal medicine, 2023-11, Vol.37 (6), p.2291-2300

2023

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A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice

PLoS pathogens, 2022-06, Vol.18 (6), p.e1010606-e1010606

2022

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Individualized chemotherapy drug dose escalation in dogs with multicentric lymphoma

Journal of veterinary internal medicine, 2023-11, Vol.37 (6), p.2402-2409

2023

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A phase II clinical trial of the Aurora and angiogenic kinase inhibitor ENMD-2076 for previously treated, advanced, or metastatic triple-negative breast cancer

Breast cancer research : BCR, 2018-08, Vol.20 (1), p.82-82, Article 82

2018

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Long-term effects of a trophic cascade in a large lake ecosystem

Proceedings of the National Academy of Sciences - PNAS, 2011-01, Vol.108 (3), p.1070-1075

2011

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Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology

Science translational medicine, 2016-02, Vol.8 (324), p.324ps5

2016

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NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger

Molecular pharmacology, 2004-05, Vol.65 (5), p.1238-1247

2004

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Autophagy and cancer therapy

Molecular pharmacology, 2014-06, Vol.85 (6), p.830-838

2014

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Structure-activity relationships for biodistribution, pharmacokinetics, and excretion of atomically precise nanoclusters in a murine model

Nanoscale, 2013-11, Vol.5 (21), p.10525

2013

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A systematic analysis of genomics-based modeling approaches for prediction of drug response to cytotoxic chemotherapies

BMC medical genomics, 2019-06, Vol.12 (1), p.87-18, Article 87

2019

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Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer

Clinical cancer research, 2013-08, Vol.19 (15), p.4149-4162

2013

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Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma

Communications biology, 2021-10, Vol.4 (1), p.1178-1178, Article 1178

2021

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Mapatumumab, an Antibody Targeting TRAIL-R1, in Combination With Paclitaxel and Carboplatin in Patients With Advanced Solid Malignancies: Results of a Phase I and Pharmacokinetic Study

Journal of clinical oncology, 2009-09, Vol.27 (26), p.4413-4421

2009

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Multicenter Phase I/II Study of Cetuximab With Paclitaxel and Carboplatin in Untreated Patients With Stage IV Non–Small-Cell Lung Cancer

Journal of clinical oncology, 2005-12, Vol.23 (34), p.8786-8793

2005

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Plasma Concentrations of Oral Ondansetron in Hospitalized Dogs Exhibiting Clinical Signs of Nausea

Veterinary sciences, 2024-03, Vol.11 (3), p.112

2024

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Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus

PloS one, 2017-09, Vol.12 (9), p.e0185089

2017

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Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension

Frontiers in physiology, 2021-09, Vol.12, p.712583-712583

2021

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Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy

Journal of the American Veterinary Medical Association, 2019-06, Vol.254 (11), p.1301-1308

2019

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Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism

Pharmacology research & perspectives, 2023-02, Vol.11 (1), p.e01052-n/a

2023

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Hydroxychloroquine: A Physiologically-Based Pharmacokinetic Model in the Context of Cancer-Related Autophagy Modulation

Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells

Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma

Identifying the ErbB/MAPK Signaling Cascade as a Therapeutic Target in Canine Bladder Cancer

Predicting chemosensitivity using drug perturbed gene dynamics

Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics

The efficacy and safety of cannabidiol as adjunct treatment for drug‐resistant idiopathic epilepsy in 51 dogs: A double‐blinded crossover study

A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice

Individualized chemotherapy drug dose escalation in dogs with multicentric lymphoma

A phase II clinical trial of the Aurora and angiogenic kinase inhibitor ENMD-2076 for previously treated, advanced, or metastatic triple-negative breast cancer

Long-term effects of a trophic cascade in a large lake ecosystem

Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology

NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger

Autophagy and cancer therapy

Structure-activity relationships for biodistribution, pharmacokinetics, and excretion of atomically precise nanoclusters in a murine model

A systematic analysis of genomics-based modeling approaches for prediction of drug response to cytotoxic chemotherapies

Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer

Immune pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma

Mapatumumab, an Antibody Targeting TRAIL-R1, in Combination With Paclitaxel and Carboplatin in Patients With Advanced Solid Malignancies: Results of a Phase I and Pharmacokinetic Study

Multicenter Phase I/II Study of Cetuximab With Paclitaxel and Carboplatin in Untreated Patients With Stage IV Non–Small-Cell Lung Cancer

Plasma Concentrations of Oral Ondansetron in Hospitalized Dogs Exhibiting Clinical Signs of Nausea

Activation of the unfolded protein response in sarcoma cells treated with rapamycin or temsirolimus

Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension

Randomized blinded controlled clinical trial to assess the effect of oral cannabidiol administration in addition to conventional antiepileptic treatment on seizure frequency in dogs with intractable idiopathic epilepsy

Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism

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