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Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer's disease in patients with rheumatoid arthritis and psoriasis

PloS one, 2020-03, Vol.15 (3), p.e0229819-e0229819

2020

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Genetic Association of Phosphodiesterases With Human Cognitive Performance

Frontiers in molecular neuroscience, 2019-02, Vol.12, p.22-22

Gurney, Mark E

2019

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The Use of Facebook Advertising to Recruit Healthy Elderly People for a Clinical Trial: Baseline Metrics

JMIR research protocols, 2018-01, Vol.7 (1), p.e20-e20

2018

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Structural basis for the design of selective phosphodiesterase 4B inhibitors

Cellular signalling, 2014-03, Vol.26 (3), p.657-663

2014

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Effects of chronic inhibition of phosphodiesterase-4D on behavior and regional rates of cerebral protein synthesis in a mouse model of fragile X syndrome

Neurobiology of disease, 2021-11, Vol.159, p.105485, Article 105485

2021

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Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury

PloS one, 2017-05, Vol.12 (5), p.e0178013-e0178013

2017

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COVID‐19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US

Alzheimer's & dementia, 2021-08, Vol.17 (8), p.1297-1306

2021

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Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

Alzheimer's research & therapy, 2021-10, Vol.13 (1), p.1-13, Article 177

2021

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Formation of High Molecular Weight Complexes of Mutant Cu,Zn-Superoxide Dismutase in a Mouse Model for Familial Amyotrophic Lateral Sclerosis

Proceedings of the National Academy of Sciences - PNAS, 2000-11, Vol.97 (23), p.12571-12576

2000

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Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy

Human molecular genetics, 2010-02, Vol.19 (3), p.454-467

2010

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A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway

Frontiers in cell and developmental biology, 2020-12, Vol.8, p.599389-599389

2020

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Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial

Nature medicine, 2021-05, Vol.27 (5), p.862-870

2021

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Synthesis and Biological Evaluation of Novel 2,4-Diaminoquinazoline Derivatives as SMN2 Promoter Activators for the Potential Treatment of Spinal Muscular Atrophy

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.449-469

2008

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PDE4 subtypes in cancer

Oncogene, 2020-05, Vol.39 (19), p.3791-3802

2020

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DcpS as a Therapeutic Target for Spinal Muscular Atrophy

ACS chemical biology, 2008-11, Vol.3 (11), p.711-722

2008

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Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)

Scientific reports, 2017-11, Vol.7 (1), p.14653-11, Article 14653

2017

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Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System

Scientific reports, 2017-01, Vol.7 (1), p.40115, Article 40115

2017

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Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

Neurotherapeutics, 2015-01, Vol.12 (1), p.49-56

2015

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Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Nature biotechnology, 2010-01, Vol.28 (1), p.63-70

2010

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Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

Neuropsychopharmacology (New York, N.Y.), 2018-10, Vol.43 (11), p.2299-2309

2018

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The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies

Journal of the neurological sciences, 1997-10, Vol.152, p.s67-s73

Gurney, Mark E

1997

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Protection from Amyloid β Peptide-Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor

The Journal of pharmacology and experimental therapeutics, 2019-11, Vol.371 (2), p.250-259

2019

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Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor

The Journal of neuroscience, 2016-07, Vol.36 (27), p.7095-7108

2016

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Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.4884-4901

2019

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Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer's disease in patients with rheumatoid arthritis and psoriasis

Genetic Association of Phosphodiesterases With Human Cognitive Performance

The Use of Facebook Advertising to Recruit Healthy Elderly People for a Clinical Trial: Baseline Metrics

Structural basis for the design of selective phosphodiesterase 4B inhibitors

Effects of chronic inhibition of phosphodiesterase-4D on behavior and regional rates of cerebral protein synthesis in a mouse model of fragile X syndrome

Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury

COVID‐19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US

Gut–microbiota–microglia–brain interactions in Alzheimer’s disease: knowledge-based, multi-dimensional characterization

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

Formation of High Molecular Weight Complexes of Mutant Cu,Zn-Superoxide Dismutase in a Mouse Model for Familial Amyotrophic Lateral Sclerosis

Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy

A Novel PDE4D Inhibitor BPN14770 Reverses Scopolamine-Induced Cognitive Deficits via cAMP/SIRT1/Akt/Bcl-2 Pathway

Inhibition of phosphodiesterase-4D in adults with fragile X syndrome: a randomized, placebo-controlled, phase 2 clinical trial

Synthesis and Biological Evaluation of Novel 2,4-Diaminoquinazoline Derivatives as SMN2 Promoter Activators for the Potential Treatment of Spinal Muscular Atrophy

PDE4 subtypes in cancer

DcpS as a Therapeutic Target for Spinal Muscular Atrophy

Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)

Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System

Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice

The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies

Protection from Amyloid β Peptide-Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor

Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders

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