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Efficacy and Safety of Sacubitril/Valsartan in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction　― Results From the PARALLEL-HF Study

Circulation Journal, 2021/04/23, Vol.85(5), pp.584-594

2021

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Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension: Results of a Randomized, Double-Blind, Placebo- and Active-Controlled Phase 2 Trial

Circulation (New York, N.Y.), 2011-11, Vol.124 (18), p.1945-1955

2011

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Angiotensin Receptor Neprilysin Inhibitor in Japanese Patients With Heart Failure and Reduced Ejection Fraction　― Baseline Characteristics and Treatment of PARALLEL-HF Trial

Circulation Journal, 2018/09/25, Vol.82(10), pp.2575-2583

2018

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Efficacy and safety of sacubitril/valsartan (LCZ696) in Japanese patients with chronic heart failure and reduced ejection fraction: Rationale for and design of the randomized, double-blind PARALLEL-HF study

Journal of cardiology, 2017-09, Vol.70 (3), p.225-231

2017

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Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles

The Journal of physiology, 2004-08, Vol.559 (1), p.103-120

2004

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Targeted Deletion of Kv4.2 Eliminates Ito,f and Results in Electrical and Molecular Remodeling, With No Evidence of Ventricular Hypertrophy or Myocardial Dysfunction

Circulation research, 2005-12, Vol.97 (12), p.1342-1350

2005

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Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes

The Journal of general physiology, 1999-05, Vol.113 (5), p.661-678

1999

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Role of Heteromultimers in the Generation of Myocardial Transient Outward K+ Currents

Circulation research, 2002-03, Vol.90 (5), p.586-593

2002

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Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes

The Journal of physiology, 1999-12, Vol.521 (3), p.587-599

1999

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Effects of Sacubitril/Valsartan Versus Olmesartan on Central Hemodynamics in the Elderly With Systolic Hypertension: The PARAMETER Study

Hypertension (Dallas, Tex. 1979), 2017-03, Vol.69 (3), p.411-420

2017

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Modulation of Kv4-encoded K+ Currents in the Mammalian Myocardium by Neuronal Calcium Sensor-1

The Journal of biological chemistry, 2002-07, Vol.277 (29), p.26436-26443

2002

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Heterogeneous Expression of Voltage-Gated Potassium Channels in the Heart: Roles in Normal Excitation and Arrhythmias

Journal of cardiovascular electrophysiology, 2002-04, Vol.13 (4), p.406-409

2002

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Efficacy and safety of sacubitril/valsartan compared with olmesartan in Asian patients with essential hypertension: A randomized, double‐blind, 8‐week study

The journal of clinical hypertension (Greenwich, Conn.), 2019-01, Vol.21 (1), p.67-76

2019

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Attenuation of the Slow Component of Delayed Rectification, Action Potential Prolongation, and Triggered Activity in Mice Expressing a Dominant-Negative Kv2 α Subunit

Circulation research, 1999-10, Vol.85 (7), p.623-633

1999

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Targeted Replacement of Kv1.5 in the Mouse Leads to Loss of the 4-Aminopyridine-Sensitive Component of IK,slow and Resistance to Drug-Induced QT Prolongation

Circulation research, 2001-05, Vol.88 (9), p.940-946

2001

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CONSISTENT ANTIHYPERTENSIVE EFFICACY OF THE RNA INTERFERENCE THERAPEUTIC ZILEBESIRAN: SUBGROUP RESULTS FROM THE KARDIA-1 PHASE 2 STUDY IN PATIENTS WITH HYPERTENSION

Journal of the American College of Cardiology, 2024-04, Vol.83 (13), p.1669-1669

2024

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Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial Infarction (PARADISE‐MI): design and baseline characteristics

European journal of heart failure, 2021-06, Vol.23 (6), p.1040-1048

2021

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Interim phase 1 part A results for ALN‐APP, the first investigational RNAi therapeutic in development for Alzheimer’s disease

Alzheimer's & dementia, 2023-12, Vol.19 (S24), p.n/a

2023

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Developing Topics

Alzheimer's & dementia, 2023-12, Vol.19 Suppl 24, p.e082650

2023

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Efficacy and Safety of Sacubitril/Valsartan in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction　― Results From the PARALLEL-HF Study

Circulation Journal, 2021/03/16, pp.CJ-20-0854

2021

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Cell Cycle-related Changes in the Voltage-gated Ca2+Currents in Cultured Newborn Rat Ventricular Myocytes

Journal of molecular and cellular cardiology, 1998-06, Vol.30 (6), p.1095-1103

1998

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Regulation of Kv4.2 and Kv1.4 K+Channel Expression by Myocardial Hypertrophic Factors in Cultured Newborn Rat Ventricular Cells

Journal of molecular and cellular cardiology, 1998-07, Vol.30 (7), p.1449-1455

1998

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Paracrine hypertrophic factors from cardiac non-myocyte cells downregulate the transient outward current density and Kv4.2 K+ channel expression in cultured rat cardiomyocytes

Cardiovascular research, 1999, Vol.41 (1), p.157-165

1999

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Characterization of mice with a combined suppression of Ito and IK, slow

American journal of physiology. Heart and circulatory physiology, 2001-09, Vol.50 (3), p.H1201-H1209

2001

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Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit

Circulation research, 2000-07, Vol.87 (1), p.73-79

2000

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Efficacy and Safety of Sacubitril/Valsartan in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction　― Results From the PARALLEL-HF Study

Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension: Results of a Randomized, Double-Blind, Placebo- and Active-Controlled Phase 2 Trial

Angiotensin Receptor Neprilysin Inhibitor in Japanese Patients With Heart Failure and Reduced Ejection Fraction　― Baseline Characteristics and Treatment of PARALLEL-HF Trial

Efficacy and safety of sacubitril/valsartan (LCZ696) in Japanese patients with chronic heart failure and reduced ejection fraction: Rationale for and design of the randomized, double-blind PARALLEL-HF study

Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles

Targeted Deletion of Kv4.2 Eliminates Ito,f and Results in Electrical and Molecular Remodeling, With No Evidence of Ventricular Hypertrophy or Myocardial Dysfunction

Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes

Role of Heteromultimers in the Generation of Myocardial Transient Outward K+ Currents

Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes

Effects of Sacubitril/Valsartan Versus Olmesartan on Central Hemodynamics in the Elderly With Systolic Hypertension: The PARAMETER Study

Modulation of Kv4-encoded K+ Currents in the Mammalian Myocardium by Neuronal Calcium Sensor-1

Heterogeneous Expression of Voltage-Gated Potassium Channels in the Heart: Roles in Normal Excitation and Arrhythmias

Efficacy and safety of sacubitril/valsartan compared with olmesartan in Asian patients with essential hypertension: A randomized, double‐blind, 8‐week study

Attenuation of the Slow Component of Delayed Rectification, Action Potential Prolongation, and Triggered Activity in Mice Expressing a Dominant-Negative Kv2 α Subunit

Targeted Replacement of Kv1.5 in the Mouse Leads to Loss of the 4-Aminopyridine-Sensitive Component of IK,slow and Resistance to Drug-Induced QT Prolongation

CONSISTENT ANTIHYPERTENSIVE EFFICACY OF THE RNA INTERFERENCE THERAPEUTIC ZILEBESIRAN: SUBGROUP RESULTS FROM THE KARDIA-1 PHASE 2 STUDY IN PATIENTS WITH HYPERTENSION

Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial Infarction (PARADISE‐MI): design and baseline characteristics

Interim phase 1 part A results for ALN‐APP, the first investigational RNAi therapeutic in development for Alzheimer’s disease

Developing Topics

Efficacy and Safety of Sacubitril/Valsartan in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction　― Results From the PARALLEL-HF Study

Cell Cycle-related Changes in the Voltage-gated Ca2+Currents in Cultured Newborn Rat Ventricular Myocytes

Regulation of Kv4.2 and Kv1.4 K+Channel Expression by Myocardial Hypertrophic Factors in Cultured Newborn Rat Ventricular Cells

Paracrine hypertrophic factors from cardiac non-myocyte cells downregulate the transient outward current density and Kv4.2 K+ channel expression in cultured rat cardiomyocytes

Characterization of mice with a combined suppression of Ito and IK, slow

Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit

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