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Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain

Nature communications, 2022-07, Vol.13 (1), p.4086-4, Article 4086

Gunthorpe, Martin J

2022

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The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

Epilepsia (Copenhagen), 2012-03, Vol.53 (3), p.412-424

2012

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Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential

British journal of pharmacology, 2009-08, Vol.157 (8), p.1301-1317

2009

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Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

Drug discovery today, 2009, Vol.14 (1), p.56-67

2009

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The binding and mechanism of a positive allosteric modulator of Kv3 channels

Nature communications, 2024-03, Vol.15 (1), p.2533-2533, Article 2533

2024

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Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)

British journal of pharmacology, 2005-03, Vol.144 (6), p.781-790

2005

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The Voltage-Gated Sodium Channel Nav1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity

The Journal of neuroscience, 2006-12, Vol.26 (50), p.12852-12860

2006

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The diversity in the vanilloid (TRPV) receptor family of ion channels

Trends in Pharmacological Sciences, 2002-04, Vol.23 (4), p.183-191

2002

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The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: Implications for clinical use

Epilepsia (Copenhagen), 2012-03, Vol.53 (3), p.425-436

2012

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Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine

The Journal of pharmacology and experimental therapeutics, 2007-05, Vol.321 (2), p.564-572

2007

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Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms

Current pharmaceutical design, 2008, Vol.14 (1), p.32-41

2008

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Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer’s disease

Brain and neuroscience advances, 2022-01, Vol.6, p.23982128221086464

2022

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Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1183-1192

2007

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TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation

European journal of pharmacology, 2006-07, Vol.540 (1), p.73-81

2006

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An animal model of chronic inflammatory pain: Pharmacological and temporal differentiation from acute models

European journal of pain, 2006-08, Vol.10 (6), p.537-537

2006

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The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity

The Journal of neuroscience, 2006-12, Vol.26 (50), p.12852-12860

2006

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Discovery of small molecule antagonists of TRPV1

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (14), p.3631-3634

2004

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Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1)

The Journal of physiology, 2000-06, Vol.525 (3), p.747-759

2000

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Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8

Molecular pharmacology, 2005-08, Vol.68 (2), p.518-527

2005

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Targeting Gut T Cell Ca2+ Release-Activated Ca2+ Channels Inhibits T Cell Cytokine Production and T-Box Transcription Factor T-Bet in Inflammatory Bowel Disease

The Journal of immunology (1950), 2009-09, Vol.183 (5), p.3454-3462

2009

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Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy

Cell reports. Medicine, 2024-02, Vol.5 (2), p.101389-101389, Article 101389

2024

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TRPV channels as temperature sensors

Cell calcium (Edinburgh), 2003-05, Vol.33 (5), p.479-487

2003

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Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3287-3291

2006

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Characterisation of 5-HT₃C, 5-HT₃D and 5-HT₃E receptor subunits: evolution, distribution and function

Journal of neurochemistry, 2009, Vol.108 (2), p.384-396

2009

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Diltiazem causes open channel block of recombinant 5-HT3 receptors

The Journal of physiology, 1999-09, Vol.519 (3), p.713-722

1999

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Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

Allosteric modulators of NR2B‐containing NMDA receptors: molecular mechanisms and therapeutic potential

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

The binding and mechanism of a positive allosteric modulator of Kv3 channels

Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)

The Voltage-Gated Sodium Channel Nav1.9 Is an Effector of Peripheral Inflammatory Pain Hypersensitivity

The diversity in the vanilloid (TRPV) receptor family of ion channels

The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: Implications for clinical use

Effects of pan- and subtype-selective N-methyl-D-aspartate receptor antagonists on cortical spreading depression in the rat: therapeutic potential for migraine

Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer’s disease

Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor

TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation

An animal model of chronic inflammatory pain: Pharmacological and temporal differentiation from acute models

The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity

Discovery of small molecule antagonists of TRPV1

Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1)

Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8

Targeting Gut T Cell Ca2+ Release-Activated Ca2+ Channels Inhibits T Cell Cytokine Production and T-Box Transcription Factor T-Bet in Inflammatory Bowel Disease

Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy

TRPV channels as temperature sensors

Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development

Characterisation of 5-HT₃C, 5-HT₃D and 5-HT₃E receptor subunits: evolution, distribution and function

Diltiazem causes open channel block of recombinant 5-HT3 receptors

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