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Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (1), p.112-117

2015

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Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

Nature biotechnology, 2014-02, Vol.32 (2), p.191-198

2014

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Engineering a protein–protein interface using a computationally designed library

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (45), p.19296-19301

2010

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Circular permutation in the Ω-loop of TEM-1 β-lactamase results in improved activity and altered substrate specificity

PloS one, 2012-04, Vol.7 (4), p.e35998

2012

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Directed Evolution of Protein Switches and Their Application to the Creation of Ligand-Binding Proteins

Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (32), p.11224-11229

2005

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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors

mAbs, 2021-01, Vol.13 (1), p.1850395

2021

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Redesigning the NEDD8 Pathway with a Bacterial Genetic Screen for Ubiquitin-Like Molecule Transfer

Journal of molecular biology, 2012-05, Vol.418 (3-4), p.161-166

2012

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Creation of an Allosteric Enzyme by Domain Insertion

Journal of molecular biology, 2004-02, Vol.336 (1), p.263-273

2004

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A T cell receptor β chain-directed antibody fusion molecule activates and expands subsets of T cells to promote antitumor activity

Science translational medicine, 2023-11, Vol.15 (724), p.eadi0258

2023

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Protein switches identified from diverse insertion libraries created using S1 nuclease digestion of supercoiled-form plasmid DNA

Biotechnology and bioengineering, 2011-11, Vol.108 (11), p.2535-2543

2011

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Circular Permutation in the [OMEGA]-Loop of TEM-1 [beta]-Lactamase Results in Improved Activity and Altered Substrate Specificity

PloS one, 2012-04, Vol.7 (4), p.e35998

2012

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Abstract 2357: T cell receptor beta chain-directed Tri-specific antibody molecules retarget V-beta T cell subsets to tumors to promote potent and durable antitumor activity

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.2357-2357

2024

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Abstract LB338: A novel class of T cell-activators targeting germline encoded TCRβ chains promotes antitumor activity in PD1-refractory models through expansion of a clonally enriched effector memory T cell subset

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB338-LB338

2023

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Development of DQ-MHC Class II Monoclonal Antibodies—A New, Targeted Therapeutic Approach in Type 1 Diabetes

Diabetes (New York, N.Y.), 2018-07, Vol.67 (Supplement_1)

2018

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Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display

Protein engineering, design and selection, 2016-01, Vol.29 (1), p.1-9

2016

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Combined computational design of a zinc binding site and a protein-protein interaction: one open zinc coordination sphere was not a robust hotspot for de novo ubiquitin binding

Proteins, structure, function, and bioinformatics, 2013-04, Vol.81 (7), p.1245-1255

2013

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Combined computational design of a zinc-binding site and a protein-protein interaction: One open zinc coordination site was not a robust hotspot for de novo ubiquitin binding

Proteins, structure, function, and bioinformatics, 2013-07, Vol.81 (7), p.1245-1255

2013

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Combined computational design of a zinc-binding site and a protein-protein interaction: One open zinc coordination site was not a robust hotspot for de novo ubiquitin binding

Proteins, structure, function, and bioinformatics, 2013-09, Vol.81 (9), p.1678-1679

2013

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A Molecular Switch Created by In Vitro Recombination of Nonhomologous Genes

Chemistry & biology, 2004-11, Vol.11 (11), p.1483-1487

2004

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Creation of molecular switches by combinatorial protein engineering

Guntas, Gurkan

2006

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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors

mAbs, 2021, Vol.13 (1)

2021

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Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

Engineering a protein–protein interface using a computationally designed library

Circular permutation in the Ω-loop of TEM-1 β-lactamase results in improved activity and altered substrate specificity

Directed Evolution of Protein Switches and Their Application to the Creation of Ligand-Binding Proteins

Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors

Redesigning the NEDD8 Pathway with a Bacterial Genetic Screen for Ubiquitin-Like Molecule Transfer

Creation of an Allosteric Enzyme by Domain Insertion

A T cell receptor β chain-directed antibody fusion molecule activates and expands subsets of T cells to promote antitumor activity

Protein switches identified from diverse insertion libraries created using S1 nuclease digestion of supercoiled-form plasmid DNA

Circular Permutation in the [OMEGA]-Loop of TEM-1 [beta]-Lactamase Results in Improved Activity and Altered Substrate Specificity

Abstract 2357: T cell receptor beta chain-directed Tri-specific antibody molecules retarget V-beta T cell subsets to tumors to promote potent and durable antitumor activity

Abstract LB338: A novel class of T cell-activators targeting germline encoded TCRβ chains promotes antitumor activity in PD1-refractory models through expansion of a clonally enriched effector memory T cell subset

Development of DQ-MHC Class II Monoclonal Antibodies—A New, Targeted Therapeutic Approach in Type 1 Diabetes

Engineering a genetically encoded competitive inhibitor of the KEAP1–NRF2 interaction via structure-based design and phage display

Combined computational design of a zinc binding site and a protein-protein interaction: one open zinc coordination sphere was not a robust hotspot for de novo ubiquitin binding

Combined computational design of a zinc-binding site and a protein-protein interaction: One open zinc coordination site was not a robust hotspot for de novo ubiquitin binding

Combined computational design of a zinc-binding site and a protein-protein interaction: One open zinc coordination site was not a robust hotspot for de novo ubiquitin binding

A Molecular Switch Created by In Vitro Recombination of Nonhomologous Genes

Creation of molecular switches by combinatorial protein engineering

Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors

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