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P2X receptor antagonists for pain management: examination of binding and physicochemical properties

Purinergic signalling, 2012-02, Vol.8 (Suppl 1), p.41-56

2012

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Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain

Bioorganic & medicinal chemistry, 2022-06, Vol.63, p.116743-116743, Article 116743

2022

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PTP1B Antisense Oligonucleotide Lowers PTP1B Protein, Normalizes Blood Glucose, and Improves Insulin Sensitivity in Diabetic Mice

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (17), p.11357-11362

2002

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Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3373-3391

2016

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Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

Diabetes (New York, N.Y.), 2003-01, Vol.52 (1), p.21-28

2003

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Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity

Journal of medicinal chemistry, 2006-06, Vol.49 (12), p.3563-3580

2006

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Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Diabetes (New York, N.Y.), 2002-08, Vol.51 (8), p.2405-2411

2002

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Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases

ACS chemical biology, 2011-03, Vol.6 (3), p.234-244

2011

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Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Journal of medicinal chemistry, 2006-07, Vol.49 (15), p.4455-4458

2006

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Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (3), p.668-672

2007

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Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1807-1810

2006

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Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

The Journal of biological chemistry, 1996-05, Vol.271 (18), p.10672-10680

1996

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Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.1811-1815

2006

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Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

Biochemical and biophysical research communications, 1997-06, Vol.235 (3), p.533-538

1997

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Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2590-2594

2006

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Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice

Molecular endocrinology (Baltimore, Md.), 2003-06, Vol.17 (6), p.1131-1143

2003

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Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes

Biochemical pharmacology, 2001-12, Vol.62 (12), p.1661-1673

2001

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Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5723-5730

2006

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Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket

The Journal of biological chemistry, 1998-06, Vol.273 (25), p.15605-15610

1998

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PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat

Molecular and cellular endocrinology, 2003-05, Vol.203 (1), p.155-168

2003

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Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras

The Journal of biological chemistry, 1995-09, Vol.270 (39), p.23007-23012

1995

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Reduction of PTP1B induces differential expression of PI3-kinase (p85α) isoforms

Biochemical and biophysical research communications, 2004-10, Vol.323 (2), p.652-659

2004

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Inhibitors of the p38 Mitogen-Activated Kinase Modulate IL-4 Induction of Low Affinity IgE Receptor (CD23) in Human Monocytes

The Journal of immunology (1950), 1998-12, Vol.161 (11), p.6005-6013

1998

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Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain

Bioorganic & medicinal chemistry, 2022-06, Vol.63, p.116743

2022

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Substituted Indazoles as Na v 1.7 Blockers for the Treatment of Pain

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3373-3391

2016

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P2X receptor antagonists for pain management: examination of binding and physicochemical properties

Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain

PTP1B Antisense Oligonucleotide Lowers PTP1B Protein, Normalizes Blood Glucose, and Improves Insulin Sensitivity in Diabetic Mice

Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain

Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice

Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity

Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis

Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors

Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode

Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors

Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice

Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond

Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket

PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat

Involvement of a Mitogen-activated Protein Kinase Signaling Pathway in the Regulation of Urokinase Promoter Activity by c-Ha-ras

Reduction of PTP1B induces differential expression of PI3-kinase (p85α) isoforms

Inhibitors of the p38 Mitogen-Activated Kinase Modulate IL-4 Induction of Low Affinity IgE Receptor (CD23) in Human Monocytes

Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain

Substituted Indazoles as Na v 1.7 Blockers for the Treatment of Pain

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