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Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats

Frontiers in endocrinology (Lausanne), 2023-01, Vol.13, p.1003017-1003017

2023

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In vitro and in vivo studies on the effect of a mitochondrial fusion promoter on Leydig cell integrity and function

Frontiers in toxicology, 2024-03, Vol.6, p.1357857-1357857

2024

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Axitinib inhibits retinal and choroidal neovascularization in in vitro and in vivo models

Experimental eye research, 2016-04, Vol.145, p.373-379

2016

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Evaluation of miR-216a and miR-217 as Potential Biomarkers of Acute Exocrine Pancreatic Toxicity in Rats

Toxicologic pathology, 2017-02, Vol.45 (2), p.321-334

2017

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Eyes on Lipinski's Rule of Five: A New "Rule of Thumb" for Physicochemical Design Space of Ophthalmic Drugs

Journal of ocular pharmacology and therapeutics, 2022-01, Vol.38 (1), p.43-55

2022

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Ocular biopharmaceutics: impact of modeling and simulation on topical ophthalmic formulation development

Drug discovery today, 2019-08, Vol.24 (8), p.1587-1597

2019

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Translational Pharmacokinetic-Pharmacodynamic Modeling for an Orally Available Novel Inhibitor of Epigenetic Regulator Enhancer of Zeste Homolog 2

The Journal of pharmacology and experimental therapeutics, 2020-05, Vol.373 (2), p.220-229

2020

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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.650-665

2018

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Ophthalmic Drug Discovery and Development

Pharmaceutical research, 2019-05, Vol.36 (5), p.69-3, Article 69

2019

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Safety Assessment of Formulation Vehicles Following Intravitreal Administration in Rabbits

Pharmaceutical research, 2018-09, Vol.35 (9), p.173-10, Article 173

2018

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Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug

Journal of medicinal chemistry, 2021-02, Vol.64 (3), p.1725-1732

2021

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Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.644-661

2021

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Antibody-Drug Conjugates

Pharmaceutical research, 2015-11, Vol.32 (11), p.3451-3452

2015

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Design, Synthesis, and Evaluation of NO-Donor Containing Carbonic Anhydrase Inhibitors To Lower Intraocular Pressure

Journal of medicinal chemistry, 2015-03, Vol.58 (6), p.2821-2833

2015

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Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2

Pharmaceutical research, 2017-12, Vol.34 (12), p.2488-2497

2017

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Pharmacokinetic Study of Vitreous and Serum Concentrations of Triamcinolone Acetonide After Posterior Sub-Tenon's Injection

American journal of ophthalmology, 2012-05, Vol.153 (5), p.939-948

2012

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Glutathione and Its Transporters in Ocular Surface Defense

The ocular surface, 2007-10, Vol.5 (4), p.269-279

2007

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Ocular disposition, pharmacokinetics, efficacy and safety of nanoparticle-formulated ophthalmic drugs

Current drug metabolism, 2007-02, Vol.8 (2), p.91-107

2007

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Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells: role in PLGA nanoparticle endocytosis

Molecular vision, 2003-10, Vol.9, p.559-568

2003

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An Assessment of the Ocular Safety of Excipient Maleic Acid Following Intravitreal Injection in Rabbits

Toxicologic pathology, 2012-07, Vol.40 (5), p.797-806

2012

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Correlation of in vitro and in vivo kinetics of nitric oxide donors in ocular tissues

Journal of ocular pharmacology and therapeutics, 2009-04, Vol.25 (2), p.105-112

2009

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Solution Formulation Development of a VEGF Inhibitor for Intravitreal Injection

AAPS PharmSciTech, 2011-03, Vol.12 (1), p.362-371

2011

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Nucleotide-induced restoration of conjunctival chloride and fluid secretion in adenovirus type 5-infected pigmented rabbit eyes

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1206-1211

2003

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Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats

In vitro and in vivo studies on the effect of a mitochondrial fusion promoter on Leydig cell integrity and function

Axitinib inhibits retinal and choroidal neovascularization in in vitro and in vivo models

Evaluation of miR-216a and miR-217 as Potential Biomarkers of Acute Exocrine Pancreatic Toxicity in Rats

Eyes on Lipinski's Rule of Five: A New "Rule of Thumb" for Physicochemical Design Space of Ophthalmic Drugs

Ocular biopharmaceutics: impact of modeling and simulation on topical ophthalmic formulation development

Translational Pharmacokinetic-Pharmacodynamic Modeling for an Orally Available Novel Inhibitor of Epigenetic Regulator Enhancer of Zeste Homolog 2

Ophthalmic Drug Discovery and Development

Safety Assessment of Formulation Vehicles Following Intravitreal Administration in Rabbits

Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)

Antibody-Drug Conjugates

Design, Synthesis, and Evaluation of NO-Donor Containing Carbonic Anhydrase Inhibitors To Lower Intraocular Pressure

Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2

Pharmacokinetic Study of Vitreous and Serum Concentrations of Triamcinolone Acetonide After Posterior Sub-Tenon's Injection

Glutathione and Its Transporters in Ocular Surface Defense

Ocular disposition, pharmacokinetics, efficacy and safety of nanoparticle-formulated ophthalmic drugs

Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells: role in PLGA nanoparticle endocytosis

An Assessment of the Ocular Safety of Excipient Maleic Acid Following Intravitreal Injection in Rabbits

Correlation of in vitro and in vivo kinetics of nitric oxide donors in ocular tissues

Solution Formulation Development of a VEGF Inhibitor for Intravitreal Injection

Nucleotide-induced restoration of conjunctival chloride and fluid secretion in adenovirus type 5-infected pigmented rabbit eyes

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