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General review on in vitro hepatocyte models and their applications

Methods in molecular biology (Clifton, N.J.), 2010-01, Vol.640, p.1

2010

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Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes

Free radical biology & medicine, 2018-02, Vol.115, p.166-178

2018

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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Nature reviews. Drug discovery, 2020-02, Vol.19 (2), p.131-148

2020

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Oxidative stress plays a major role in chlorpromazine‐induced cholestasis in human HepaRG cells

Hepatology (Baltimore, Md.), 2013-04, Vol.57 (4), p.1518-1529

2013

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Evolving concepts in liver tissue modeling and implications for in vitro toxicology

Expert opinion on drug metabolism & toxicology, 2008-10, Vol.4 (10), p.1279-1294

2008

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Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

Drug metabolism and disposition, 2010-03, Vol.38 (3), p.516

2010

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Pro-inflammatory cytokines enhance dilatation of bile canaliculi caused by cholestatic antibiotics

Toxicology in vitro, 2019-08, Vol.58, p.51-59

2019

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Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation

Drug metabolism and disposition, 2017-12, Vol.45 (12), p.1292-1303

2017

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Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1780-1793

2016

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Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes

Toxicological Sciences, 2015-10, Vol.147 (2), p.573-587

2015

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Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential

Toxicological Sciences, 2019-04, Vol.168 (2), p.474-485

2019

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Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies

Drug metabolism and disposition, 2008-06, Vol.36 (6), p.1111

2008

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Induction of vesicular steatosis by amiodarone and tetracycline is associated with up‐regulation of lipogenic genes in heparg cells

Hepatology (Baltimore, Md.), 2011-06, Vol.53 (6), p.1895-1905

2011

Volltextzugriff (PDF)

Antibiotics-induced oxidative stress

Current opinion in toxicology, 2020-04, Vol.20-21, p.23-28

2020

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Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells

Review of Economic Dynamics, 2014-09, Vol.141 (1), p.244-253

2014

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Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.151

2012

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Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α

Toxicology letters, 2016-09, Vol.258, p.71-86

2016

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Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds

Toxicology and applied pharmacology, 2012-01, Vol.258 (2), p.176-187

2012

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A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells

Toxicological Sciences, 2018-01, Vol.161 (1), p.48-57

2018

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Setup and Use of HepaRG Cells in Cholestasis Research

Methods in molecular biology (Clifton, N.J.), 2019, Vol.1981, p.291

2019

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The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

Chemico-biological interactions, 2007-05, Vol.168 (1), p.66-73

2007

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Optimization of the HepaRG cell model for drug metabolism and toxicity studies

Toxicology in vitro, 2012-12, Vol.26 (8), p.1278-1285

2012

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Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells

Chemico-biological interactions, 2014-02, Vol.209, p.68-76

2014

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Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells

Drug metabolism and disposition, 2014-09, Vol.42 (9), p.1556

2014

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General review on in vitro hepatocyte models and their applications

Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Oxidative stress plays a major role in chlorpromazine‐induced cholestasis in human HepaRG cells

Evolving concepts in liver tissue modeling and implications for in vitro toxicology

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

Pro-inflammatory cytokines enhance dilatation of bile canaliculi caused by cholestatic antibiotics

Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation

Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes

Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies

Induction of vesicular steatosis by amiodarone and tetracycline is associated with up‐regulation of lipogenic genes in heparg cells

Antibiotics-induced oxidative stress

Different dose-dependent mechanisms are involved in early cyclosporine a-induced cholestatic effects in hepaRG cells

Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells

Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α

Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds

A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells

Setup and Use of HepaRG Cells in Cholestasis Research

Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies

The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells

Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells

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