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A β-Oxidation-Resistant Lipoxin A4 Analog Treats Hapten-Induced Colitis by Attenuating Inflammation and Immune Dysfunction

Proceedings of the National Academy of Sciences - PNAS, 2004-11, Vol.101 (44), p.15736-15741

2004

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Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis

The Journal of immunology (1950), 2002-05, Vol.168 (10), p.5260-5267

2002

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Lipoxins and novel 15‐epi‐lipoxin analogs display potent anti‐inflammatory actions after oral administration

British journal of pharmacology, 2004-09, Vol.143 (1), p.43-52

2004

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Second-generation beta-oxidation resistant 3-oxa-lipoxin A4 analogs

Prostaglandins, leukotrienes and essential fatty acids, 2005-09, Vol.73 (3-4), p.245-250

2005

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Lipoxin A₄ stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism

The FASEB journal, 2007-12, Vol.21 (14), p.3877-3884

2007

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Novel 3-Oxa Lipoxin A4 Analogues with Enhanced Chemical and Metabolic Stability Have Anti-inflammatory Activity in Vivo

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.2157-2165

2004

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Design, Synthesis, and Activity of a Novel Series of Factor Xa Inhibitors: Optimization of Arylamidine Groups

Journal of medicinal chemistry, 2002-06, Vol.45 (12), p.2484-2493

2002

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Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase

Bioorganic & medicinal chemistry, 2008-05, Vol.16 (9), p.4963-4983

2008

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Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase

Bioorganic & medicinal chemistry letters, 2008-07, Vol.18 (14), p.3891-3894

2008

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Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors

Bioorganic & medicinal chemistry letters, 2008-07, Vol.18 (14), p.3895-3898

2008

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The mechanism of the chorismate mutase reaction

Journal of the American Chemical Society, 1987-08, Vol.109 (16), p.5013-5019

1987

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Synthesis, Characterization, and Structure−Activity Relationships of Amidine-Substituted (Bis)benzylidene-Cycloketone Olefin Isomers as Potent and Selective Factor Xa Inhibitors

Journal of medicinal chemistry, 1999-12, Vol.42 (26), p.5415-5425

1999

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Conformation of a Bound Inhibitor of Blood Coagulant Factor Xa

Biochemistry (Easton), 2003-07, Vol.42 (26), p.7942-7949

2003

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Human Factor Xa Bound Amidine Inhibitor Conformation by Double Rotational-Echo Double Resonance Nuclear Magnetic Resonance and Molecular Dynamics Simulations

Journal of medicinal chemistry, 2003-01, Vol.46 (3), p.359-363

2003

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Development of a homogeneous time-resolved fluorescence leukotriene B4 assay for determining the activity of leukotriene A4 hydrolase

Journal of biomolecular screening, 2007-06, Vol.12 (4), p.536-545

2007

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Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin

Acta crystallographica. Section D, Biological crystallography., 1999-08, Vol.55 (8), p.1395-1404

1999

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Conformations of Trypsin-Bound Amidine Inhibitors of Blood Coagulant Factor Xa by Double REDOR NMR and MD Simulations

Journal of medicinal chemistry, 1999-09, Vol.42 (19), p.3910-3918

1999

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Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines

Bioorganic & medicinal chemistry, 2002-03, Vol.10 (3), p.657-666

2002

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Benzimidazole-Based fXa inhibitors with improved thrombin and trypsin selectivity

Bioorganic & medicinal chemistry letters, 2002-05, Vol.12 (9), p.1311-1314

2002

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Synthesis of 13C3,15N4-labeled factor Xa inhibitor

Journal of labelled compounds & radiopharmaceuticals, 2001-03, Vol.44 (4), p.247-256

2001

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Design and synthesis of aminophenol-Based factor xa inhibitors

Bioorganic & medicinal chemistry letters, 2002-05, Vol.12 (9), p.1307-1310

2002

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Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A(4) hydrolase

Bioorganic & medicinal chemistry, 2008-05, Vol.16 (9), p.4963

2008

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Synthesis of brominated heptanones and bromoform by a bromoperoxidase of marine origin

Biochemistry (Easton), 1981-06, Vol.20 (13), p.3724-3731

1981

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(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: Identification of a Highly Active Inhibitor of Blood Coagulation Factor Xa

Journal of medicinal chemistry, 1998-09, Vol.41 (19), p.3551-3556

1998

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A β-Oxidation-Resistant Lipoxin A4 Analog Treats Hapten-Induced Colitis by Attenuating Inflammation and Immune Dysfunction

Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis

Lipoxins and novel 15‐epi‐lipoxin analogs display potent anti‐inflammatory actions after oral administration

Second-generation beta-oxidation resistant 3-oxa-lipoxin A4 analogs

Lipoxin A₄ stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism

Novel 3-Oxa Lipoxin A4 Analogues with Enhanced Chemical and Metabolic Stability Have Anti-inflammatory Activity in Vivo

Design, Synthesis, and Activity of a Novel Series of Factor Xa Inhibitors: Optimization of Arylamidine Groups

Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase

Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase

Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa

The mechanism of the chorismate mutase reaction

Synthesis, Characterization, and Structure−Activity Relationships of Amidine-Substituted (Bis)benzylidene-Cycloketone Olefin Isomers as Potent and Selective Factor Xa Inhibitors

Conformation of a Bound Inhibitor of Blood Coagulant Factor Xa

Human Factor Xa Bound Amidine Inhibitor Conformation by Double Rotational-Echo Double Resonance Nuclear Magnetic Resonance and Molecular Dynamics Simulations

Development of a homogeneous time-resolved fluorescence leukotriene B4 assay for determining the activity of leukotriene A4 hydrolase

Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin

Conformations of Trypsin-Bound Amidine Inhibitors of Blood Coagulant Factor Xa by Double REDOR NMR and MD Simulations

Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines

Benzimidazole-Based fXa inhibitors with improved thrombin and trypsin selectivity

Synthesis of 13C3,15N4-labeled factor Xa inhibitor

Design and synthesis of aminophenol-Based factor xa inhibitors

Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A(4) hydrolase

Synthesis of brominated heptanones and bromoform by a bromoperoxidase of marine origin

(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: Identification of a Highly Active Inhibitor of Blood Coagulation Factor Xa

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