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Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing

Nucleic acids research, 2021-10, Vol.49 (18), p.10250

2021

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Recognition of double-stranded DNA using LNA-modified toehold Invader probes

Organic & biomolecular chemistry, 2021-11, Vol.19 (42), p.9276-929

2021

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4′‑C‑Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing

Journal of the American Chemical Society, 2017-10, Vol.139 (41), p.14542-14555

2017

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Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Nucleic acids research, 2018-09, Vol.46 (16), p.8090

2018

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Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications

Chemical science (Cambridge), 2015-08, Vol.6 (8), p.5006-5015

2015

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Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)

Journal of organic chemistry, 2014-06, Vol.79 (11), p.5047-5061

2014

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C5-amino acid functionalized LNA: positively poised for antisense applications

Chemical communications (Cambridge, England), 2014-08, Vol.50 (64), p.9007-9009

2014

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Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA

Journal of organic chemistry, 2013-10, Vol.78 (19), p.9560-9570

2013

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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Nature biotechnology, 2022-10, Vol.40 (10), p.1500-1508

2022

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Head-to-head comparison of LNA, γPNA, INA and Invader probes targeting mixed-sequence double-stranded DNA

Organic & biomolecular chemistry, 2020-01, Vol.18 (1), p.56-65

2020

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Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles

Chemical communications (Cambridge, England), 2015-10, Vol.51 (81), p.15051-15054

2015

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Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

Journal of the American Chemical Society, 2023-09, Vol.145 (36), p.19691-19706

2023

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Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β‑C‑methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects

Journal of the American Chemical Society, 2022-08, Vol.144 (32), p.14517-14534

2022

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Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes

Organic & biomolecular chemistry, 2020-06, Vol.18 (24), p.4645-4655

2020

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Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2'-triphenylene- and coronene-functionalized RNA monomers

Organic & biomolecular chemistry, 2017-11, Vol.15 (44), p.9362-9371

2017

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Recognition of Mixed-Sequence DNA Duplexes: Design Guidelines for Invaders Based on 2′‑O‑(Pyren-1-yl)methyl-RNA Monomers

Journal of organic chemistry, 2013-12, Vol.78 (23), p.12040-12048

2013

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Head-to-head comparison of LNA, MP γPNA, INA and Invader probes targeting mixed-sequence double-stranded DNA

Organic & biomolecular chemistry, 2020-01, Vol.18 (1), p.56-65

2020

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Synthesis and biophysical characterization of oligonucleotides modified with O2'-alkylated RNA monomers featuring substituted pyrene moieties

Organic & biomolecular chemistry, 2019-01, Vol.17 (3), p.609-621

2019

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Carbohydrate-Functionalized Locked Nucleic Acids: Oligonucleotides with Extraordinary Binding Affinity, Target Specificity, and Enzymatic Stability

Organic letters, 2014-06, Vol.16 (12), p.3308-3311

2014

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Sandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens

Chemical communications (Cambridge, England), 2013-10, Vol.49 (84), p.9851-9853

2013

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Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers

Organic & biomolecular chemistry, 2014-10, Vol.12 (39), p.7758-7773

2014

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C5-Functionalized LNA: Unparalleled Hybridization Properties and Enzymatic Stability

Chembiochem : a European journal of chemical biology, 2009-11, Vol.10 (17), p.2740-2743

2009

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C5-Alkynyl-Functionalized α‑L‑LNA: Synthesis, Thermal Denaturation Experiments and Enzymatic Stability

Journal of organic chemistry, 2014-06, Vol.79 (11), p.5062-5073

2014

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Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs)

Chemical communications (Cambridge, England), 2010-07, Vol.46 (27), p.4929-4931

2010

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Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2′-O-(Pyren-1-yl)methyl-ribonucleotides

Chembiochem : a European journal of chemical biology, 2013-09, Vol.14 (13), p.1534-1538

2013

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Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing

Recognition of double-stranded DNA using LNA-modified toehold Invader probes

4′‑C‑Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing

Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

Invader probes: Harnessing the energy of intercalation to facilitate recognition of chromosomal DNA for diagnostic applications

Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)

C5-amino acid functionalized LNA: positively poised for antisense applications

Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Head-to-head comparison of LNA, γPNA, INA and Invader probes targeting mixed-sequence double-stranded DNA

Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles

Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β‑C‑methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects

Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes

Recognition of mixed-sequence DNA using double-stranded probes with interstrand zipper arrangements of O2'-triphenylene- and coronene-functionalized RNA monomers

Recognition of Mixed-Sequence DNA Duplexes: Design Guidelines for Invaders Based on 2′‑O‑(Pyren-1-yl)methyl-RNA Monomers

Head-to-head comparison of LNA, MP γPNA, INA and Invader probes targeting mixed-sequence double-stranded DNA

Synthesis and biophysical characterization of oligonucleotides modified with O2'-alkylated RNA monomers featuring substituted pyrene moieties

Carbohydrate-Functionalized Locked Nucleic Acids: Oligonucleotides with Extraordinary Binding Affinity, Target Specificity, and Enzymatic Stability

Sandwich assay for mixed-sequence recognition of double-stranded DNA: invader-based detection of targets specific to foodborne pathogens

Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2'-alkylated RNA monomers

C5-Functionalized LNA: Unparalleled Hybridization Properties and Enzymatic Stability

C5-Alkynyl-Functionalized α‑L‑LNA: Synthesis, Thermal Denaturation Experiments and Enzymatic Stability

Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs)

Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2′-O-(Pyren-1-yl)methyl-ribonucleotides

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