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Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity

Chemical research in toxicology, 2001-06, Vol.14 (6), p.611-650

Guengerich, F. Peter

2001

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Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide

The FEBS journal, 2008-07, Vol.275 (14), p.3706-3717

2008

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Degradation Pathway of Bisphenol A: Does ipso Substitution Apply to Phenols Containing a Quaternary α-Carbon Structure in the para Position

Applied and Environmental Microbiology, 2007-08, Vol.73 (15), p.4776-4784

2007

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Metabolism of chemical carcinogens

Carcinogenesis (New York), 2000-03, Vol.21 (3), p.345-351

GUENGERICH, F. P

2000

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Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians

The Journal of pharmacology and experimental therapeutics, 1994-07, Vol.270 (1), p.414

1994

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Rate-Limiting Steps in Cytochrome P450 Catalysis

Biological chemistry, 2002-10, Vol.383 (10), p.1553-1564

Guengerich, F Peter

2002

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Oxidation of Indole by Cytochrome P450 Enzymes

Biochemistry (Easton), 2000-11, Vol.39 (45), p.13817-13824

2000

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Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1

Cancer research (Chicago, Ill.), 1996-07, Vol.56 (13), p.2979-2984

1996

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Drug metabolism by Escherichia coli expressing human cytochromes P450

Nature biotechnology, 1997-08, Vol.15 (8), p.784-788

1997

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Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps

The Journal of biological chemistry, 2002-09, Vol.277 (37), p.33711-33719

2002

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Cytochrome P450s and other enzymes in drug metabolism and toxicity

The AAPS journal, 2006-03, Vol.8 (1), p.E101-E111

Guengerich, F Peter

2006

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Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability

Drug metabolism and disposition, 1995-12, Vol.23 (12), p.1315

1995

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Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

Chemical research in toxicology, 1991-07, Vol.4 (4), p.391-407

1991

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Rate-Determining Steps in Phenacetin Oxidations by Human Cytochrome P450 1A2 and Selected Mutants

Biochemistry (Easton), 2000-09, Vol.39 (37), p.11319-11329

2000

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Inhibition of Human Cytochrome P450 1A1-, 1A2-, and 1B1-Mediated Activation of Procarcinogens to Genotoxic Metabolites by Polycyclic Aromatic Hydrocarbons

Chemical research in toxicology, 2006-02, Vol.19 (2), p.288-294

2006

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Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat

Drug metabolism and disposition, 1992-09, Vol.20 (5), p.753

1992

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Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity

Toxicology Letters, 1994-02, Vol.70 (2), p.133-138

Peter Guengerich, F.

1994

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Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations

Xenobiotica, 2006-12, Vol.36 (12), p.1201-1209

2006

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Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro

Drug metabolism and disposition, 2000-08, Vol.28 (8), p.895

2000

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Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples

The Journal of pharmacology and experimental therapeutics, 1991-03, Vol.256 (3), p.1189

1991

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Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products

Archives of biochemistry and biophysics, 2001-11, Vol.395 (1), p.25

2001

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Uncommon P450-catalyzed reactions

Current drug metabolism, 2001-06, Vol.2 (2), p.93

Guengerich, F P

2001

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Comparative Studies on the Catalytic Roles of Cytochrome P450 2C9 and Its Cys- and Leu-Variants in the Oxidation of Warfarin, Flurbiprofen, and Diclofenac by Human Liver Microsomes

Biochemical pharmacology, 1998-07, Vol.56 (2), p.243-251

1998

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Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation

Drug metabolism and disposition, 1993-05, Vol.21 (3), p.403

1993

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Purification and characterization of human liver microsomal cytochrome P-450 2A6

Molecular pharmacology, 1991-11, Vol.40 (5), p.679-685

1991

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Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity

Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide

Degradation Pathway of Bisphenol A: Does ipso Substitution Apply to Phenols Containing a Quaternary α-Carbon Structure in the para Position

Metabolism of chemical carcinogens

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians

Rate-Limiting Steps in Cytochrome P450 Catalysis

Oxidation of Indole by Cytochrome P450 Enzymes

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1

Drug metabolism by Escherichia coli expressing human cytochromes P450

Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps

Cytochrome P450s and other enzymes in drug metabolism and toxicity

Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

Rate-Determining Steps in Phenacetin Oxidations by Human Cytochrome P450 1A2 and Selected Mutants

Inhibition of Human Cytochrome P450 1A1-, 1A2-, and 1B1-Mediated Activation of Procarcinogens to Genotoxic Metabolites by Polycyclic Aromatic Hydrocarbons

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat

Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity

Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations

Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples

Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products

Uncommon P450-catalyzed reactions

Comparative Studies on the Catalytic Roles of Cytochrome P450 2C9 and Its Cys- and Leu-Variants in the Oxidation of Warfarin, Flurbiprofen, and Diclofenac by Human Liver Microsomes

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation

Purification and characterization of human liver microsomal cytochrome P-450 2A6

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