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Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

Osteoarthritis and cartilage, 2016-12, Vol.24 (12), p.2013-2021

2016

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Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix

Osteoarthritis and cartilage, 2017-11, Vol.25 (11), p.1858-1867

2017

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Automated MRI assessment confirms cartilage thickness modification in patients with knee osteoarthritis: post-hoc analysis from a phase II sprifermin study

Osteoarthritis and cartilage, 2020-11, Vol.28 (11), p.1432-1436

2020

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Low levels of type II collagen formation (PRO-C2) are associated with response to sprifermin: a pre-defined, exploratory biomarker analysis from the FORWARD study

Osteoarthritis and cartilage, 2022-01, Vol.30 (1), p.92-99

2022

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Recombinant human FGF18 preserves depth-dependent mechanical inhomogeneity in articular cartilage

European Cells and Materials, 2019-08, Vol.38, p.23-38

2019

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Predicting knee replacement in participants eligible for disease-modifying osteoarthritis drug treatment with structural endpoints

Osteoarthritis and cartilage, 2020-06, Vol.28 (6), p.782-791

2020

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Tissue distribution of sprifermin (recombinant human fibroblast growth factor 18) in the rat following intravenous and intra-articular injection

Osteoarthritis and cartilage open, 2020-09, Vol.2 (3), p.100068-100068, Article 100068

2020

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OP0059 Efficacy and safety of intra-articular sprifermin in symptomatic radiographic knee osteoarthritis: pre-specified analysis of 3-year data from a 5-year randomised, placebo-controlled, phase ii study

Annals of the rheumatic diseases, 2018-06, Vol.77 (Suppl 2), p.80

2018

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Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice

The Journal of clinical investigation, 2001-02, Vol.107 (4), p.439-447

2001

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Sprifermin (rhfgf18) has an anabolic effect on human osteoarthritic chondrocytes involving fgfr3 and erk1/2 but not p38α and JNKS

Osteoarthritis and cartilage, 2014-04, Vol.22, p.S164-S164

2014

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Penalized linear discriminant analysis reveals divergent gait patterns in three surgically-induced OA models

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S107-S108

2016

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Establishment of a co-culture system to MIMIC OA progression without adding of cytokines

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S69-S70

2016

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Spontaneous home cage activity is sensitive to anti-NGF treatment or can be linked to joint stiffness in different models of surgery-induced osteoarthritis

Osteoarthritis and cartilage, 2016-04, Vol.24, p.S498-S499

2016

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Elevated levels of CRPM, an inflammatory biomarker correlating with disease activity in RA, are prognostic of radiographic knee OA

Osteoarthritis and cartilage, 2017-04, Vol.25, p.S83-S84

2017

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Elevated levels of CRPM, an inflammatory biomarker correlating with disease activity in RA, are prognostic of radiographic knee OA

Osteoarthritis and cartilage, 2017-04, Vol.25, p.S32-S32

2017

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Identification of fibroblast growth factor-18 as a molecule to protect and regenerate articular cartilage

Osteoarthritis and cartilage, 2013-04, Vol.21, p.S31-S31

2013

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Identification of fibroblast growth factor-18 as a molecule to protect and regenerate articular cartilage

Osteoarthritis and cartilage, 2013-04, Vol.21, p.S107-S107

2013

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Recombinant human fibroblast growth factor-18 (rhFG18) promotes bovine articular chondrocyte proliferation and cartilage matrix production in vitro

Osteoarthritis and cartilage, 2012-04, Vol.20, p.S135-S135

2012

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Intra-articular sprifermin therapy reduces total knee replacements: accumulated evidence from translational and clinical data

Osteoarthritis and cartilage, 2021-04, Vol.29, p.S277-S278

2021

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Two year tibiofemoral joint cartilage loss is weakly correlated with increased pain among knees with lower baseline cartilage thickness

Osteoarthritis and cartilage, 2018-04, Vol.26, p.S250-S250

2018

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Pain medication reporting and patient-reported outcomes in the years prior to knee replacement: challenges to assessing symptomatic experiences

Osteoarthritis and cartilage, 2018-04, Vol.26, p.S238-S239

2018

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Soluble markers of cartilage in the forward study - a prospective-retrospective hypothesis generating study for identification of a low cartilage repair endotype

Osteoarthritis and cartilage, 2020-04, Vol.28, p.S61-S62

2020

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A low repair endotype is predictive for response to FGF-18 treatment: data from the phase II oa forward study

Osteoarthritis and cartilage, 2021-04, Vol.29, p.S144

2021

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Progressor rates of femorotibial cartilage loss stratified by radiographic disease stage, 1 to 4-year observation intervals, and MRI protocols – Data from the osteoarthritis initiative

Osteoarthritis and cartilage, 2019-04, Vol.27, p.S53-S54

2019

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Structural progressor thresholds of femorotibial cartilage change over 1 to 4-years for different MRI orientations and contrasts – data from the osteoarthritis initiative

Osteoarthritis and cartilage, 2019-04, Vol.27, p.S315-S316

2019

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Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix

Automated MRI assessment confirms cartilage thickness modification in patients with knee osteoarthritis: post-hoc analysis from a phase II sprifermin study

Low levels of type II collagen formation (PRO-C2) are associated with response to sprifermin: a pre-defined, exploratory biomarker analysis from the FORWARD study

Recombinant human FGF18 preserves depth-dependent mechanical inhomogeneity in articular cartilage

Predicting knee replacement in participants eligible for disease-modifying osteoarthritis drug treatment with structural endpoints

Tissue distribution of sprifermin (recombinant human fibroblast growth factor 18) in the rat following intravenous and intra-articular injection

OP0059 Efficacy and safety of intra-articular sprifermin in symptomatic radiographic knee osteoarthritis: pre-specified analysis of 3-year data from a 5-year randomised, placebo-controlled, phase ii study

Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice

Sprifermin (rhfgf18) has an anabolic effect on human osteoarthritic chondrocytes involving fgfr3 and erk1/2 but not p38α and JNKS

Penalized linear discriminant analysis reveals divergent gait patterns in three surgically-induced OA models

Establishment of a co-culture system to MIMIC OA progression without adding of cytokines

Spontaneous home cage activity is sensitive to anti-NGF treatment or can be linked to joint stiffness in different models of surgery-induced osteoarthritis

Elevated levels of CRPM, an inflammatory biomarker correlating with disease activity in RA, are prognostic of radiographic knee OA

Elevated levels of CRPM, an inflammatory biomarker correlating with disease activity in RA, are prognostic of radiographic knee OA

Identification of fibroblast growth factor-18 as a molecule to protect and regenerate articular cartilage

Identification of fibroblast growth factor-18 as a molecule to protect and regenerate articular cartilage

Recombinant human fibroblast growth factor-18 (rhFG18) promotes bovine articular chondrocyte proliferation and cartilage matrix production in vitro

Intra-articular sprifermin therapy reduces total knee replacements: accumulated evidence from translational and clinical data

Two year tibiofemoral joint cartilage loss is weakly correlated with increased pain among knees with lower baseline cartilage thickness

Pain medication reporting and patient-reported outcomes in the years prior to knee replacement: challenges to assessing symptomatic experiences

Soluble markers of cartilage in the forward study - a prospective-retrospective hypothesis generating study for identification of a low cartilage repair endotype

A low repair endotype is predictive for response to FGF-18 treatment: data from the phase II oa forward study

Progressor rates of femorotibial cartilage loss stratified by radiographic disease stage, 1 to 4-year observation intervals, and MRI protocols – Data from the osteoarthritis initiative

Structural progressor thresholds of femorotibial cartilage change over 1 to 4-years for different MRI orientations and contrasts – data from the osteoarthritis initiative

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