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Oxidative Dearomatization of Indoles via Pd-Catalyzed C–H Oxygenation: An Entry to C2-Quaternary Indolin-3-ones

Organic letters, 2016-04, Vol.18 (7), p.1534-1537

2016

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Medicinal Chemistry Education: Molecular Level Understanding of All Medicinal Properties and Innovative Strategies

Journal of medicinal chemistry, 2024-10

Guchhait, Sankar K

2024

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Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents

ACS omega, 2018-08, Vol.3 (8), p.9754-9769

2018

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Molecular medicinal insights into scaffold hopping-based drug discovery success

Drug discovery today, 2024-01, Vol.29 (1), p.103845-103845, Article 103845

2024

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Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents

ACS omega, 2018-02, Vol.3 (2), p.1955-1969

2018

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ZrCl4-Mediated Regio- and Chemoselective Friedel–Crafts Acylation of Indole

Journal of organic chemistry, 2011-06, Vol.76 (11), p.4753-4758

2011

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CuSO4–Glucose for in Situ Generation of Controlled Cu(I)–Cu(II) Bicatalysts: Multicomponent Reaction of Heterocyclic Azine and Aldehyde with Alkyne, and Cycloisomerization toward Synthesis of N-Fused Imidazoles

Journal of organic chemistry, 2012-05, Vol.77 (9), p.4438-4444

2012

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Rutaecarpine-inspired scaffold-hopping strategy and Ullmann cross-coupling based synthetic approach: Identification of pyridopyrimidinone-indole based novel anticancer chemotypes

Bioorganic & medicinal chemistry, 2024-07, Vol.109, p.117799, Article 117799

2024

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Synthesis of Heterocyclic‐Fused Furans and Dihydrofurans via (4+1)‐Annulation with Ylide: Exploration of Unique Reactivity Behavior of α‐Carbonyl Sulfoxonium Ylide

European journal of organic chemistry, 2022-04, Vol.2022 (16), p.n/a

2022

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Natural‐Product‐Inspired Discovery of Trimethoxyphenyl‐1,2,4‐triazolosulfonamides as Potent Tubulin Polymerization Inhibitors

ChemMedChem, 2024-01, Vol.19 (1), p.e202300562-n/a

2024

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Annulation of Conjugated Azine-Imine with a Sulfoxonium Ylide in a Noncarbenoid Route to Synthesize Multisubstituted Imidazole-Fused Heterocycles

Journal of organic chemistry, 2021-04, Vol.86 (7), p.5380-5387

2021

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Pd-Catalyzed Ag(I)-Promoted C3-Arylation of Pyrido[1,2‑a]pyrimidin-4-ones with Bromo/Iodo-Arenes

Journal of organic chemistry, 2015-08, Vol.80 (16), p.8482-8488

2015

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Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile

Organic & biomolecular chemistry, 2010-08, Vol.8 (16), p.3631-3634

2010

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N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase

Journal of medicinal chemistry, 2011-07, Vol.54 (14), p.5013-5030

2011

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Synthesis of 2‑Arylpyridopyrimidinones, 6‑Aryluracils, and Tri- and Tetrasubstituted Conjugated Alkenes via Pd-Catalyzed Enolic C–O Bond Activation–Arylation

Journal of organic chemistry, 2015-06, Vol.80 (12), p.6342-6349

2015

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Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3439-3451

2016

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Desilylative activation of TMSCN in chemoselective Strecker-Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purines

Organic & biomolecular chemistry, 2014-09, Vol.12 (34), p.6694-6705

2014

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Organocatalyzed umpolung addition for synthesis of heterocyclic-fused arylidene-imidazolones as anticancer agents

Bioorganic & medicinal chemistry, 2022-08, Vol.67, p.116835-116835, Article 116835

2022

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Scaffold overlay of flavonoid-inspired molecules: Discovery of 2,3-diaryl-pyridopyrimidin-4-imine/ones as dual hTopo-II and tubulin targeting anticancer agents

Bioorganic chemistry, 2024-11, Vol.152, p.107738, Article 107738

2024

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Microtubule‐targeting agents impair kinesin‐2‐dependent nuclear transport of β‐catenin: Evidence of inhibition of Wnt/β‐catenin signaling as an important antitumor mechanism of microtubule‐targeting agents

The FASEB journal, 2021-04, Vol.35 (4), p.e21539-n/a

2021

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C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules

Biochemical pharmacology, 2019-12, Vol.170, p.113663-113663, Article 113663

2019

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A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C (sp 3 ) H–N synthon efficiently constructs indolylisoindolinones

Chemical communications (Cambridge, England), 2022-10, Vol.58 (84), p.11827-11830

2022

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Synthesis of Polysubstituted 2‑Aminoimidazoles via Alkene-Diamination of Guanidine with Conjugated α‑Bromoalkenones

Journal of organic chemistry, 2017-03, Vol.82 (5), p.2745-2752

2017

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Synthesis of Polyfunctionalized Pyrroles via a Tandem Reaction of Michael Addition and Intramolecular Cyanide-Mediated Nitrile-to-Nitrile Condensation

Journal of organic chemistry, 2018-05, Vol.83 (10), p.5807-5815

2018

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Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα

European journal of medicinal chemistry, 2016-10, Vol.122, p.43-54

2016

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Oxidative Dearomatization of Indoles via Pd-Catalyzed C–H Oxygenation: An Entry to C2-Quaternary Indolin-3-ones

Medicinal Chemistry Education: Molecular Level Understanding of All Medicinal Properties and Innovative Strategies

Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents

Molecular medicinal insights into scaffold hopping-based drug discovery success

Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents

ZrCl4-Mediated Regio- and Chemoselective Friedel–Crafts Acylation of Indole

CuSO4–Glucose for in Situ Generation of Controlled Cu(I)–Cu(II) Bicatalysts: Multicomponent Reaction of Heterocyclic Azine and Aldehyde with Alkyne, and Cycloisomerization toward Synthesis of N-Fused Imidazoles

Rutaecarpine-inspired scaffold-hopping strategy and Ullmann cross-coupling based synthetic approach: Identification of pyridopyrimidinone-indole based novel anticancer chemotypes

Synthesis of Heterocyclic‐Fused Furans and Dihydrofurans via (4+1)‐Annulation with Ylide: Exploration of Unique Reactivity Behavior of α‐Carbonyl Sulfoxonium Ylide

Natural‐Product‐Inspired Discovery of Trimethoxyphenyl‐1,2,4‐triazolosulfonamides as Potent Tubulin Polymerization Inhibitors

Annulation of Conjugated Azine-Imine with a Sulfoxonium Ylide in a Noncarbenoid Route to Synthesize Multisubstituted Imidazole-Fused Heterocycles

Pd-Catalyzed Ag(I)-Promoted C3-Arylation of Pyrido[1,2‑a]pyrimidin-4-ones with Bromo/Iodo-Arenes

Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile

N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase

Synthesis of 2‑Arylpyridopyrimidinones, 6‑Aryluracils, and Tri- and Tetrasubstituted Conjugated Alkenes via Pd-Catalyzed Enolic C–O Bond Activation–Arylation

Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety

Desilylative activation of TMSCN in chemoselective Strecker-Ugi type reaction: functional fused imidazoles as building blocks as an entry route to annulated purines

Organocatalyzed umpolung addition for synthesis of heterocyclic-fused arylidene-imidazolones as anticancer agents

Scaffold overlay of flavonoid-inspired molecules: Discovery of 2,3-diaryl-pyridopyrimidin-4-imine/ones as dual hTopo-II and tubulin targeting anticancer agents

Microtubule‐targeting agents impair kinesin‐2‐dependent nuclear transport of β‐catenin: Evidence of inhibition of Wnt/β‐catenin signaling as an important antitumor mechanism of microtubule‐targeting agents

C12, a combretastatin-A4 analog, exerts anticancer activity by targeting microtubules

A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C (sp 3 ) H–N synthon efficiently constructs indolylisoindolinones

Synthesis of Polysubstituted 2‑Aminoimidazoles via Alkene-Diamination of Guanidine with Conjugated α‑Bromoalkenones

Synthesis of Polyfunctionalized Pyrroles via a Tandem Reaction of Michael Addition and Intramolecular Cyanide-Mediated Nitrile-to-Nitrile Condensation

Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα

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