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AMP-activated protein kinase and cancer

Acta Physiologica, 2009-05, Vol.196 (1), p.55-63

2009

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Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

Oncogene, 2013-01, Vol.32 (5), p.663-669

2013

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Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

Oncogene, 2006-10, Vol.25 (48), p.6347-6360

2006

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A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

Nature communications, 2018-03, Vol.9 (1), p.1061-15, Article 1061

2018

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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

Oncogene, 2013-06, Vol.32 (25), p.3091-3100

2013

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Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway

Oncogene, 2015-07, Vol.34 (27), p.3536-3546

2015

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The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

Cell death and differentiation, 2011-01, Vol.18 (1), p.133-144

2011

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Regulation of glycolysis and gluconeogenesis by acetylation of PKM and PEPCK

Cold Spring Harbor Symposia on Quantitative Biology, 2011, Vol.76, p.285-289

2011

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KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation

Oncogene, 2016-08, Vol.35 (32), p.4179-4190

2016

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Wildtype Kras2 can inhibit lung carcinogenesis in mice

Nature genetics, 2001-09, Vol.29 (1), p.25-33

2001

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Cell, 2003-11, Vol.115 (5), p.577-590

2003

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Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment

Human molecular genetics, 2009-04, Vol.18 (R1), p.R94-R100

2009

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Nature cell biology, 2002-09, Vol.4 (9), p.648-657

2002

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Regulation of STAT3 by Direct Binding to the Rac1 GTPase

Science (American Association for the Advancement of Science), 2000-10, Vol.290 (5489), p.144-147

2000

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The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus

Cellular Signalling, 1994-08, Vol.6 (6), p.581-589

Guan, K.-L.

1994

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

Genes & development, 2004-07, Vol.18 (13), p.1533-1538

2004

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Signalling mechanisms mediating neuronal responses to guidance cues

Nature reviews. Neuroscience, 2003-12, Vol.4 (12), p.941-956

2003

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Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae

Genes & development, 1997-07, Vol.11 (13), p.1690-1702

1997

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Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate

The Journal of biological chemistry, 1991-09, Vol.266 (26), p.17026-17030

1991

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A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase

Genes & development, 1999-11, Vol.13 (21), p.2811-2827

1999

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Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

The Journal of biological chemistry, 1999-06, Vol.274 (24), p.16741-16746

1999

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A Role for NF-κB Essential Modifier/IκB Kinase-γ (NEMO/IKKγ) Ubiquitination in the Activation of the IκB Kinase Complex by Tumor Necrosis Factor-α

The Journal of biological chemistry, 2003-09, Vol.278 (39), p.37297-37305

2003

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Glut3 addiction is a druggable vulnerability for a molecularly defined subpopulation of glioblastoma

Annals of oncology, 2017-10, Vol.28, p.vii24-vii24

2017

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Positive and negative regulation of Raf kinase activity and function by phosphorylation

The EMBO journal, 2001-07, Vol.20 (14), p.3716-3727

2001

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Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases

The Journal of biological chemistry, 1993-11, Vol.268 (32), p.23933-23939

1993

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AMP-activated protein kinase and cancer

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

Regulation of glycolysis and gluconeogenesis by acetylation of PKM and PEPCK

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation

Wildtype Kras2 can inhibit lung carcinogenesis in mice

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Regulation of STAT3 by Direct Binding to the Rac1 GTPase

The mitogen activated protein kinase signal transduction pathway: From the cell surface to the nucleus

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

Signalling mechanisms mediating neuronal responses to guidance cues

Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate

A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase

Negative Regulation of the Forkhead Transcription Factor FKHR by Akt

A Role for NF-κB Essential Modifier/IκB Kinase-γ (NEMO/IKKγ) Ubiquitination in the Activation of the IκB Kinase Complex by Tumor Necrosis Factor-α

Glut3 addiction is a druggable vulnerability for a molecularly defined subpopulation of glioblastoma

Positive and negative regulation of Raf kinase activity and function by phosphorylation

Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases

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