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Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series

Biochemistry (Easton), 2003-01, Vol.42 (3), p.718-727

2003

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Structure-based Optimization of MurF Inhibitors

Chemical biology & drug design, 2006-01, Vol.67 (1), p.58-65

2006

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Design, synthesis and structure–activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2653-2658

2005

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An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin

Organic & biomolecular chemistry, 2013-07, Vol.11 (28), p.4680-4685

2013

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From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae

Chemical biology & drug design, 2007-06, Vol.69 (6), p.395-404

2007

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Studies of mild dehydrogenations in heterocyclic systems

Tetrahedron letters, 1997-01, Vol.38 (3), p.331-334

1997

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Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway

The Journal of pharmacology and experimental therapeutics, 2008-02, Vol.324 (2), p.507-516

2008

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Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure

Protein science, 2005-12, Vol.14 (12), p.3039-3047

2005

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Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1961-1965

2007

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Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3- d]pyrimidines as adenosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (11), p.2803-2807

2005

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Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors

Journal of medicinal chemistry, 2006-06, Vol.49 (13), p.3770-3773

2006

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Structure-Based Characterization and Optimization of Novel Hydrophobic Binding Interactions in a Series of Pyrrolidine Influenza Neuraminidase Inhibitors

Journal of medicinal chemistry, 2005-06, Vol.48 (12), p.3980-3990

2005

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Corrosion and Cavitation Erosion Behaviors of Two Marine Propeller Materials in Clean and Sulfide-Polluted 3.5% NaCl Solutions

Acta metallurgica sinica : English letters, 2017-08, Vol.30 (8), p.712-720

2017

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Studies toward funiculosin. Intramolecular carbonyl condensations using carboxamidimidazolide intermediates

Tetrahedron letters, 1997-01, Vol.38 (3), p.327-330

1997

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Discovery of 4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine, an Orally Active, Non-Nucleoside Adenosine Kinase Inhibitor

Journal of medicinal chemistry, 2001-06, Vol.44 (13), p.2133-2138

2001

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trans-2,6-, 3,6- and 4,6-Diaza-5,6,6a,7,8,12b-hexahydrobenzo[ C]phenanthrene-10,11-diols as dopamine agonists

Bioorganic & medicinal chemistry letters, 1999-05, Vol.9 (10), p.1341-1346

1999

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Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (11), p.2716-2719

2005

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N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Acetyl-CoA Carboxylase InhibitorsImprovement of Cardiovascular and Neurological Liabilities via Structural Modifications

Journal of medicinal chemistry, 2007-03, Vol.50 (5), p.1078-1082

2007

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Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3299-3302

2004

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5,6,7-Trisubstituted 4-Aminopyrido[2,3-d]pyrimidines as Novel Inhibitors of Adenosine Kinase

Journal of medicinal chemistry, 2003-11, Vol.46 (24), p.5249-5257

2003

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Synthesis of 4-alkyl-3,5-dibromo-, 3-bromo-4,5-dialkyl- and 3,4,5-trialkylpyridines via sequential metalation and metal-halogen exchange of 3,5-dibromopyridine

Tetrahedron letters, 1996-04, Vol.37 (15), p.2565-2568

1996

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The synthesis and structure–activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1803-1807

2007

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Structure–activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6078-6081

2006

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Structure–activity relationships of novel potent MurF inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.267-270

2004

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Stereoselective synthesis of all four geometric isomers of internal 1,3-butadienes by the condensation reaction of aldehydes with the .gamma.-trimethylsilyl-substituted allylboranes

Journal of the American Chemical Society, 1990-05, Vol.112 (11), p.4424-4431

1990

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Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series

Structure-based Optimization of MurF Inhibitors

Design, synthesis and structure–activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae

An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin

From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae

Studies of mild dehydrogenations in heterocyclic systems

Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway

Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure

Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents

Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3- d]pyrimidines as adenosine kinase inhibitors

Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors

Structure-Based Characterization and Optimization of Novel Hydrophobic Binding Interactions in a Series of Pyrrolidine Influenza Neuraminidase Inhibitors

Corrosion and Cavitation Erosion Behaviors of Two Marine Propeller Materials in Clean and Sulfide-Polluted 3.5% NaCl Solutions

Studies toward funiculosin. Intramolecular carbonyl condensations using carboxamidimidazolide intermediates

Discovery of 4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine, an Orally Active, Non-Nucleoside Adenosine Kinase Inhibitor

trans-2,6-, 3,6- and 4,6-Diaza-5,6,6a,7,8,12b-hexahydrobenzo[ C]phenanthrene-10,11-diols as dopamine agonists

Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives

N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Acetyl-CoA Carboxylase InhibitorsImprovement of Cardiovascular and Neurological Liabilities via Structural Modifications

Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants

5,6,7-Trisubstituted 4-Aminopyrido[2,3-d]pyrimidines as Novel Inhibitors of Adenosine Kinase

Synthesis of 4-alkyl-3,5-dibromo-, 3-bromo-4,5-dialkyl- and 3,4,5-trialkylpyridines via sequential metalation and metal-halogen exchange of 3,5-dibromopyridine

The synthesis and structure–activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications

Structure–activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity

Structure–activity relationships of novel potent MurF inhibitors

Stereoselective synthesis of all four geometric isomers of internal 1,3-butadienes by the condensation reaction of aldehydes with the .gamma.-trimethylsilyl-substituted allylboranes

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