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Clinical Parameters and Metabolomic Biomarkers That Predict Inhospital Outcomes in Patients With ST-Segment Elevated Myocardial Infarctions

Frontiers in physiology, 2022-02, Vol.12, p.820240-820240

2022

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P186 - pH dependent CES1 mediated hydrolysis of vixotrigine in human liver microsomes

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S79-S79

2020

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The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects

Journal of labelled compounds & radiopharmaceuticals, 2021-02, Vol.64 (2), p.65-72

2021

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Developmental expression of the major human hepatic CYP3A enzymes

The Journal of pharmacology and experimental therapeutics, 2003-11, Vol.307 (2), p.573-582

2003

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BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS

Drug metabolism and pharmacokinetics, 2022-02, Vol.42, p.100433-100433, Article 100433

2022

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Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4775-4780

2016

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Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

ACS medicinal chemistry letters, 2015-03, Vol.6 (3), p.254-259

2015

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Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1151-1163

2012

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In vitro and in vivo metabolism of a selective δ-opioid receptor

Drug metabolism and disposition, 2011-10, Vol.39 (10), p.1883-1894

2011

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Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors

Bioorganic & medicinal chemistry, 2007-09, Vol.15 (17), p.5912-5949

2007

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Use of High-Performance Liquid Chromatography−Tandem Mass Spectrometry To Distinguish Panax ginseng C. A. Meyer (Asian Ginseng) and Panax quinquefolius L. (North American Ginseng)

Analytical chemistry (Washington), 2000-11, Vol.72 (21), p.5417-5422

2000

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Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors

Journal of the American Society for Mass Spectrometry, 2005-02, Vol.16 (2), p.271-279

2005

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Quantitative Analysis of Lycopene Isomers in Human Plasma Using High-Performance Liquid Chromatography−Tandem Mass Spectrometry

Analytical chemistry (Washington), 2003-02, Vol.75 (4), p.812-817

2003

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Late-occurring and long-circulating metabolites of GABA A receptor modulator AZD7325 involving metabolic cyclization and aromatization: Relevance to mist analysis and application for patient compliance

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S73

2018

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Selective Gas-Phase Cleavage at the Peptide Bond C-Terminal to Aspartic Acid in Fixed-Charge Derivatives of Asp-Containing Peptides

Analytical chemistry (Washington), 2000-12, Vol.72 (23), p.5804-5813

2000

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Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms

Journal of agricultural and food chemistry, 2001-05, Vol.49 (5), p.2472-2479

2001

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Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [ 14 C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [ 14 C]Thiocyanate

Drug metabolism and disposition, 2024-05, Vol.52 (5), p.323-336

2024

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Preclinical safety, toxicokinetics and metabolism of BIIB131, a novel prothrombolytic agent for acute stroke

Regulatory toxicology and pharmacology, 2023-12, Vol.145, p.105498-105498, Article 105498

2023

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Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes

Xenobiotica, 2022-02, Vol.52 (2), p.105-112

2022

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Metabolic aromatization of N-alkyl-1,2,3,4-tetrahydroquinoline substructures to quinolinium by human liver microsomes and horseradish peroxidase

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.2044-2055

2006

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Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

Journal of medicinal chemistry, 2020-12, Vol.63 (24), p.15564-15590

2020

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The Importance of Tracking “Missing” Metabolites: How and Why?

Journal of medicinal chemistry, 2023-12, Vol.66 (23), p.15586-15612

2023

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CYP-Mediated Sulfoximine Deimination of AZD6738

Drug metabolism and disposition, 2017-11, Vol.45 (11), p.1133-1138

2017

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Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors

Bioorganic & medicinal chemistry letters, 2022-03, Vol.60, p.128549-128549, Article 128549

2022

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Identification of the carboxylic acid functionality in protonated drug metabolite model compounds by using tandem mass spectrometry based on ion-molecule reactions coupled with high performance liquid chromatography

International journal of mass spectrometry, 2021-05, Vol.463, p.116551, Article 116551

2021

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Clinical Parameters and Metabolomic Biomarkers That Predict Inhospital Outcomes in Patients With ST-Segment Elevated Myocardial Infarctions

P186 - pH dependent CES1 mediated hydrolysis of vixotrigine in human liver microsomes

The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects

Developmental expression of the major human hepatic CYP3A enzymes

BTK-inhibitor drug covalent binding to lysine in human serum albumin using LC-MS/MS

Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct

In vitro and in vivo metabolism of a selective δ-opioid receptor

Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors

Use of High-Performance Liquid Chromatography−Tandem Mass Spectrometry To Distinguish Panax ginseng C. A. Meyer (Asian Ginseng) and Panax quinquefolius L. (North American Ginseng)

Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors

Quantitative Analysis of Lycopene Isomers in Human Plasma Using High-Performance Liquid Chromatography−Tandem Mass Spectrometry

Late-occurring and long-circulating metabolites of GABA A receptor modulator AZD7325 involving metabolic cyclization and aromatization: Relevance to mist analysis and application for patient compliance

Selective Gas-Phase Cleavage at the Peptide Bond C-Terminal to Aspartic Acid in Fixed-Charge Derivatives of Asp-Containing Peptides

Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms

Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [ 14 C]Cyanide from 2-Cyanothiophene and Subsequent Formation of [ 14 C]Thiocyanate

Preclinical safety, toxicokinetics and metabolism of BIIB131, a novel prothrombolytic agent for acute stroke

Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes

Metabolic aromatization of N-alkyl-1,2,3,4-tetrahydroquinoline substructures to quinolinium by human liver microsomes and horseradish peroxidase

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

The Importance of Tracking “Missing” Metabolites: How and Why?

CYP-Mediated Sulfoximine Deimination of AZD6738

Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors

Identification of the carboxylic acid functionality in protonated drug metabolite model compounds by using tandem mass spectrometry based on ion-molecule reactions coupled with high performance liquid chromatography

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