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Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML

International journal of molecular sciences, 2023-02, Vol.24 (4), p.4235

2023

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Early changes in rpS6 phosphorylation and BH3 profiling predict response to chemotherapy in AML cells

PloS one, 2018-05, Vol.13 (5), p.e0196805-e0196805

2018

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Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling

PloS one, 2018-01, Vol.13 (1), p.e0190682-e0190682

2018

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The effects of temperature reduction on gene expression and oxidative stress in skeletal muscle from adult zebrafish

Comparative biochemistry and physiology. Toxicology & pharmacology, 2004-07, Vol.138 (3), p.363-373

2004

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A same‐day assay predicts apoptotic response to combined BCL‐2 and MCL‐1 BH3‐mimetic targeting in multiple myeloma cells

EJHaem, 2021-02, Vol.2 (1), p.40-47

2021

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The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells

Molecular cancer therapeutics, 2010-03, Vol.9 (3), p.661-672

2010

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P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the aurora-B kinase inhibitor barasertib-hQPA

BMC cancer, 2011-06, Vol.11 (1), p.254-254, Article 254

2011

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NK cells rapidly remove B16F10 tumor cells in a perforin and interferon-gamma independent manner in vivo

Cancer Immunology, Immunotherapy, 2007-08, Vol.56 (8), p.1153-1161

2007

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Impaired S-Phase Arrest in Acute Myeloid Leukemia Cells with a FLT3 Internal Tandem Duplication Treated with Clofarabine

Clinical cancer research, 2009-12, Vol.15 (23), p.7291-7298

2009

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Immunodeficient mice have elevated numbers of NK cells in non-lymphoid tissues

Experimental cell research, 2006-11, Vol.312 (19), p.3920-3926

2006

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Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials

Clinical cancer research, 2007-12, Vol.13 (23), p.7059-7066

2007

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P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway

Experimental hematology, 2005, Vol.33 (1), p.62-72

2005

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Ten‐minute chat

Veterinary record, 2011-10, Vol.169 (15), p.ii-ii

Grundy, Martin

2011

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Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

Oncotarget, 2017-03, Vol.8 (10), p.16220-16232

2017

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Comparison of Two Rapid Predictive Methods for Therapeutic Targeting in Acute Myeloid Leukaemia Cells

Blood, 2016-12, Vol.128 (22), p.1704-1704

2016

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The multi-kinase inhibitor TG02 overcomes signalling activation by survival factors to deplete MCL1 and XIAP and induce cell death in primary acute myeloid leukaemia cells

British journal of haematology, 2012-10, Vol.159 (2), p.191-203

2012

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A short term biomarker-based assay predicts apoptotic response to combined BCL-2/MCL-1 BH3 mimetic targeting in Myeloma cells

Clinical lymphoma, myeloma and leukemia, 2019-10, Vol.19 (10), p.e124-e124

2019

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Molecular cloning and sequence analysis of the Danio rerio catalase gene

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000-12, Vol.127 (4), p.447-457

2000

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Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells

Oncotarget, 2018-12, Vol.9 (102), p.37777-37789

2018

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Abstract 331: Targeting MCL1 in NPM1-mutant AML

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.331-331

2014

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The multi‐kinase inhibitor TG 02 overcomes signalling activation by survival factors to deplete MCL 1 and XIAP and induce cell death in primary acute myeloid leukaemia cells

British journal of haematology, 2012-10, Vol.159 (2), p.191-203

2012

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Analysis of the Interaction of Induction Regimens with P-Glycoprotein Expression In Patients with Acute Myeloid Leukaemia: Results From the MRC AML15 Trial

Blood, 2010-11, Vol.116 (21), p.2724-2724

2010

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A Polymorphism In the 3'UTR Region of ABCB1 Is Associated with Increased Allele Activity with Corresponding Increases In P-Glycoprotein Expression and Function

Blood, 2010-11, Vol.116 (21), p.3990-3990

2010

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FLT3‐ITD expression levels and their effect on STAT5 in AML with and without NPM mutations

British journal of haematology, 2009-12, Vol.147 (5), p.653-661

2009

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P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors

Experimental hematology, 2007-12, Vol.35 (12), p.1793-1800

2007

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Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML

Early changes in rpS6 phosphorylation and BH3 profiling predict response to chemotherapy in AML cells

Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling

The effects of temperature reduction on gene expression and oxidative stress in skeletal muscle from adult zebrafish

A same‐day assay predicts apoptotic response to combined BCL‐2 and MCL‐1 BH3‐mimetic targeting in multiple myeloma cells

The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells

P-glycoprotein and breast cancer resistance protein in acute myeloid leukaemia cells treated with the aurora-B kinase inhibitor barasertib-hQPA

NK cells rapidly remove B16F10 tumor cells in a perforin and interferon-gamma independent manner in vivo

Impaired S-Phase Arrest in Acute Myeloid Leukemia Cells with a FLT3 Internal Tandem Duplication Treated with Clofarabine

Immunodeficient mice have elevated numbers of NK cells in non-lymphoid tissues

Sequential Influences of Leukemia-Specific and Genetic Factors on P-Glycoprotein Expression in Blasts from 817 Patients Entered into the National Cancer Research Network Acute Myeloid Leukemia 14 and 15 Trials

P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway

Ten‐minute chat

Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

Comparison of Two Rapid Predictive Methods for Therapeutic Targeting in Acute Myeloid Leukaemia Cells

The multi-kinase inhibitor TG02 overcomes signalling activation by survival factors to deplete MCL1 and XIAP and induce cell death in primary acute myeloid leukaemia cells

A short term biomarker-based assay predicts apoptotic response to combined BCL-2/MCL-1 BH3 mimetic targeting in Myeloma cells

Molecular cloning and sequence analysis of the Danio rerio catalase gene

Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells

Abstract 331: Targeting MCL1 in NPM1-mutant AML

The multi‐kinase inhibitor TG 02 overcomes signalling activation by survival factors to deplete MCL 1 and XIAP and induce cell death in primary acute myeloid leukaemia cells

Analysis of the Interaction of Induction Regimens with P-Glycoprotein Expression In Patients with Acute Myeloid Leukaemia: Results From the MRC AML15 Trial

A Polymorphism In the 3'UTR Region of ABCB1 Is Associated with Increased Allele Activity with Corresponding Increases In P-Glycoprotein Expression and Function

FLT3‐ITD expression levels and their effect on STAT5 in AML with and without NPM mutations

P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors

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