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Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection

Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (28), p.7426-7431

2017

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Atomic structure of, and valine binding to the regulatory ACT domain of the Mycobacterium tuberculosis Rel protein

The FEBS journal, 2021-04, Vol.288 (7), p.2377-2397

2021

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Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (11), p.1-9

2021

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Mycobacterium tuberculosis PanD Structure–Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor

ACS chemical biology, 2021-06, Vol.16 (6), p.1030-1039

2021

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Power Stroke Angular Velocity Profiles of Archaeal A-ATP Synthase Versus Thermophilic and Mesophilic F-ATP Synthase Molecular Motors

The Journal of biological chemistry, 2016-12, Vol.291 (49), p.25351-25363

2016

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Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer

Nature communications, 2018-12, Vol.9 (1), p.5370-5370, Article 5370

2018

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The NMR solution structure of Mycobacterium tuberculosis F‐ATP synthase subunit ε provides new insight into energy coupling inside the rotary engine

The FEBS journal, 2018-03, Vol.285 (6), p.1111-1128

2018

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The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation

The Journal of biological chemistry, 2017-07, Vol.292 (27), p.11262-11279

2017

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Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD

ACS infectious diseases, 2017-11, Vol.3 (11), p.807-819

2017

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Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents

Bioorganic & medicinal chemistry, 2022-11, Vol.74, p.117046-117046, Article 117046

2022

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Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa

Journal of bacteriology, 2018-02, Vol.200 (3)

2018

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AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

Scientific reports, 2017-07, Vol.7 (1), p.5159-15, Article 5159

2017

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Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

Scientific reports, 2019-11, Vol.9 (1), p.16759-15, Article 16759

2019

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Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

Acta crystallographica. Section D, Biological crystallography., 2015-11, Vol.71 (11), p.2309-2327

2015

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Frozen and freeze‐dried solvent/detergent treated plasma: Two different pharmaceutical formulations with comparable quality

Transfusion (Philadelphia, Pa.), 2022-12, Vol.62 (12), p.2621-2630

2022

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Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

Journal of Virology, 2008-01, Vol.82 (1), p.173-183

2008

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Anti-Mycobacterium abscessus Activity of Tuberculosis F-ATP Synthase Inhibitor GaMF1

Antimicrobial agents and chemotherapy, 2022-05, Vol.66 (5), p.e0001822-e0001822

2022

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Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin‑α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells

ACS infectious diseases, 2019-06, Vol.5 (6), p.932-948

2019

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Barnacle cement protein as an efficient bioinspired corrosion inhibitor

Communications materials, 2024-02, Vol.5 (1), p.11-15, Article 11

2024

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GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876

Microbiology spectrum, 2023-12, Vol.11 (6), p.e0228223-e0228223

2023

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The Unique C-Terminal Extension of Mycobacterial F-ATP Synthase Subunit α Is the Major Contributor to Its Latent ATP Hydrolysis Activity

Antimicrobial agents and chemotherapy, 2020-11, Vol.64 (12)

2020

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Antituberculosis Activity of the Antimalaria Cytochrome bcc Oxidase Inhibitor SCR0911

ACS infectious diseases, 2020-04, Vol.6 (4), p.725-737

2020

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Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide

Trends in pharmacological sciences (Regular ed.), 2019-12, Vol.40 (12), p.930-940

2019

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NMR studies reveal a novel grab and release mechanism for efficient catalysis of the bacterial 2‐Cys peroxiredoxin machinery

The FEBS journal, 2015-12, Vol.282 (23), p.4620-4638

2015

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Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery

Expert opinion on drug discovery, 2023-08, Vol.18 (8), p.917-927

2023

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Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection

Atomic structure of, and valine binding to the regulatory ACT domain of the Mycobacterium tuberculosis Rel protein

Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis

Mycobacterium tuberculosis PanD Structure–Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor

Power Stroke Angular Velocity Profiles of Archaeal A-ATP Synthase Versus Thermophilic and Mesophilic F-ATP Synthase Molecular Motors

Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer

The NMR solution structure of Mycobacterium tuberculosis F‐ATP synthase subunit ε provides new insight into energy coupling inside the rotary engine

The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation

Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD

Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents

Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa

AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

Frozen and freeze‐dried solvent/detergent treated plasma: Two different pharmaceutical formulations with comparable quality

Crystal Structure of the NS3 Protease-Helicase from Dengue Virus

Anti-Mycobacterium abscessus Activity of Tuberculosis F-ATP Synthase Inhibitor GaMF1

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin‑α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells

Barnacle cement protein as an efficient bioinspired corrosion inhibitor

GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876

The Unique C-Terminal Extension of Mycobacterial F-ATP Synthase Subunit α Is the Major Contributor to Its Latent ATP Hydrolysis Activity

Antituberculosis Activity of the Antimalaria Cytochrome bcc Oxidase Inhibitor SCR0911

Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide

NMR studies reveal a novel grab and release mechanism for efficient catalysis of the bacterial 2‐Cys peroxiredoxin machinery

Novel targets and inhibitors of the Mycobacterium tuberculosis cytochrome bd oxidase to foster anti-tuberculosis drug discovery

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