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Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

Arteriosclerosis, thrombosis, and vascular biology, 2019-04, Vol.39 (4), p.799-809

2019

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P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

The Journal of clinical investigation, 2011-07, Vol.121 (7), p.2932-2944

2011

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Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H

The Journal of immunology (1950), 2021-04, Vol.206 (8), p.1784-1792

2021

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Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

The Journal of biological chemistry, 2017-05, Vol.292 (21), p.8616-8629

2017

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Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Blood, 2017-10, Vol.130 (14), p.1661-1670

2017

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Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates

Thrombosis and haemostasis, 2013, Vol.110 (1), p.162-172

2013

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The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

Blood, 2021-12, Vol.138 (22), p.2173-2184

2021

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A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo

Blood, 2010-11, Vol.116 (19), p.3981-3989

2010

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Factor XI–dependence of surface- and tissue factor–initiated thrombus propagation in primates

Blood, 2003-08, Vol.102 (3), p.953-955

2003

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Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

Blood, 2012-05, Vol.119 (20), p.4762-4768

2012

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The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear

Thrombosis research, 2015-01, Vol.135 (1), p.155-160

2015

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Skeletal muscle myosin promotes coagulation by binding factor XI via its A3 domain and enhancing thrombin-induced factor XI activation

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101567-101567, Article 101567

2022

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Thrombin generation and activity in multiple sclerosis

Metabolic brain disease, 2021-03, Vol.36 (3), p.407-420

2021

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Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low‐density lipoprotein receptor‐deficient mice

Journal of thrombosis and haemostasis, 2021-04, Vol.19 (4), p.1001-1017

2021

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Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI

PloS one, 2016-10, Vol.11 (10), p.e0165172-e0165172

2016

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Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Blood, 2015-02, Vol.125 (9), p.1488-1496

2015

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Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Blood, 2021-07, Vol.138 (2), p.178-189

2021

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Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function

American Journal of Physiology: Cell Physiology, 2016-03, Vol.310 (5), p.C373-C380

2016

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Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI)

Arteriosclerosis, thrombosis, and vascular biology, 2019-07, Vol.39 (7), p.1390-1401

2019

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Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2)

Arteriosclerosis, thrombosis, and vascular biology, 2009-10, Vol.29 (10), p.1602-1607

2009

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Suppression of Arterial Thrombosis Without Affecting Hemostatic Parameters With a Cell-Penetrating PAR1 Pepducin

Circulation (New York, N.Y.), 2012-07, Vol.126 (1), p.83-91

2012

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Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

Research and practice in thrombosis and haemostasis, 2020-02, Vol.4 (2), p.205-216

2020

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Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Platelets (Edinburgh), 2019-01, Vol.30 (1), p.126-135

2019

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Safety and tolerability of the protein C activator AB002 in end-stage renal disease patients on hemodialysis: a randomized phase 2 trial

Communications medicine, 2024-07, Vol.4 (1), p.153-11, Article 153

2024

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New Directions in Infection-Associated Ischemic Stroke

Journal of clinical neurology (Seoul, Korea), 2024-03, Vol.20 (2), p.140-152

2024

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Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates

The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial

A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo

Factor XI–dependence of surface- and tissue factor–initiated thrombus propagation in primates

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear

Skeletal muscle myosin promotes coagulation by binding factor XI via its A3 domain and enhancing thrombin-induced factor XI activation

Thrombin generation and activity in multiple sclerosis

Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low‐density lipoprotein receptor‐deficient mice

Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus

Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function

Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI)

Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2)

Suppression of Arterial Thrombosis Without Affecting Hemostatic Parameters With a Cell-Penetrating PAR1 Pepducin

Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Safety and tolerability of the protein C activator AB002 in end-stage renal disease patients on hemodialysis: a randomized phase 2 trial

New Directions in Infection-Associated Ischemic Stroke

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