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A metabolic pathway for bile acid dehydroxylation by the gut microbiome

Nature (London), 2020-06, Vol.582 (7813), p.566-570

2020

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A naturally occurring antiviral ribonucleotide encoded by the human genome

Nature (London), 2018-06, Vol.558 (7711), p.610-614

2018

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The new epoch of structural insights into radical SAM enzymology

Current opinion in structural biology, 2023-12, Vol.83, p.102720-102720, Article 102720

2023

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Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB

Nature (London), 2021-09, Vol.597 (7877), p.566-570

2021

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Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides

Journal of the American Chemical Society, 2017-08, Vol.139 (34), p.11734-11744

2017

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Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (38), p.19126-19135

2019

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CMPK2 restricts Zika virus replication by inhibiting viral translation

PLoS pathogens, 2023-04, Vol.19 (4), p.e1011286-e1011286

2023

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The Fragile Brain: Stress Vulnerability, Negative Affect and GABAergic Neurocircuits in Psychosis

Schizophrenia bulletin, 2019-10, Vol.45 (6), p.1170-1183

2019

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Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life

Biochemistry (Easton), 2021-07, Vol.60 (26), p.2116-2129

2021

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Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine

Nucleic acids research, 2018-09, Vol.46 (17), p.9160

2018

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high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (34), p.13815-13820

2013

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X‑ray and EPR Characterization of the Auxiliary Fe–S Clusters in the Radical SAM Enzyme PqqE

Biochemistry (Easton), 2018-02, Vol.57 (8), p.1306-1315

2018

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Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

Molecular cell, 2022-05, Vol.82 (9), p.1631-1642.e6

2022

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X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry

Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (40), p.15949-15954

2013

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X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (21), p.8519-8524

2013

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

Science (American Association for the Advancement of Science), 2011-05, Vol.332 (6033), p.1089-1092

2011

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Viperin Reveals Its True Function

Annual review of virology, 2020-09, Vol.7 (1), p.421-446

2020

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Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (33), p.10354-10358

2015

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Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA

Science (American Association for the Advancement of Science), 2016-04, Vol.352 (6283), p.309-312

2016

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Structural basis for non-radical catalysis by TsrM, a radical SAM methylase

Nature chemical biology, 2021-04, Vol.17 (4), p.485

2021

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A Radically Different Mechanism for S-Adenosylmethionine—Dependent Methyltransferases

Science (American Association for the Advancement of Science), 2011-04, Vol.332 (6029), p.604-607

2011

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Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

eLife, 2021-10, Vol.10

2021

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Substrate Positioning Controls the Partition between Halogenation and Hydroxylation in the Aliphatic Halogenase, SyrB2

Proceedings of the National Academy of Sciences - PNAS, 2009-10, Vol.106 (42), p.17723-17728

2009

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NosN, a Radical S‑Adenosylmethionine Methylase, Catalyzes Both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide

Journal of the American Chemical Society, 2017-12, Vol.139 (48), p.17438-17445

2017

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Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe–5S Cluster for Sulfur Insertion

Journal of the American Chemical Society, 2024-01, Vol.146 (3), p.1860-1873

2024

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A metabolic pathway for bile acid dehydroxylation by the gut microbiome

A naturally occurring antiviral ribonucleotide encoded by the human genome

The new epoch of structural insights into radical SAM enzymology

Structural basis for tRNA methylthiolation by the radical SAM enzyme MiaB

Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

CMPK2 restricts Zika virus replication by inhibiting viral translation

The Fragile Brain: Stress Vulnerability, Negative Affect and GABAergic Neurocircuits in Psychosis

Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life

Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine

high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases

X‑ray and EPR Characterization of the Auxiliary Fe–S Clusters in the Radical SAM Enzyme PqqE

Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication

X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry

X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

Viperin Reveals Its True Function

Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis

Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA

Structural basis for non-radical catalysis by TsrM, a radical SAM methylase

A Radically Different Mechanism for S-Adenosylmethionine—Dependent Methyltransferases

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

Substrate Positioning Controls the Partition between Halogenation and Hydroxylation in the Aliphatic Halogenase, SyrB2

NosN, a Radical S‑Adenosylmethionine Methylase, Catalyzes Both C1 Transfer and Formation of the Ester Linkage of the Side-Ring System during the Biosynthesis of Nosiheptide

Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe–5S Cluster for Sulfur Insertion

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