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Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival

Blood, 2004-01, Vol.103 (2), p.689-694

2004

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Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL

Blood, 2007-01, Vol.109 (2), p.729-739

2007

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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

Nature (London), 2000-04, Vol.404 (6781), p.995-999

2000

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Increased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation

Autoimmunity (Chur, Switzerland), 2011-03, Vol.44 (2), p.69-81

2011

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Elevated Serum B-Lymphocyte Stimulator Levels in Patients With Familial Lymphoproliferative Disorders

Journal of clinical oncology, 2006-02, Vol.24 (6), p.983-987

2006

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MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Molecular cancer therapeutics, 2016-09, Vol.15 (9), p.2155-2165

2016

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An APRIL to remember: novel TNF ligands as therapeutic targets

Nature reviews. Drug discovery, 2006-03, Vol.5 (3), p.235-246

2006

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IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis

Journal of Allergy and Clinical Immunology, 2006-02, Vol.117 (2), p.418-425

2006

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Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

Nature immunology, 2004-07, Vol.5 (7), p.752-760

2004

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TACI-Ig Neutralizes Molecules Critical for B Cell Development and Autoimmune Disease: Impaired B Cell Maturation in Mice Lacking BLyS

Immunity (Cambridge, Mass.), 2001-08, Vol.15 (2), p.289-302

2001

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B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin

Arthritis research & therapy, 2010-01, Vol.12 (2), p.R48-R48, Article R48

2010

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Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome

Blood, 2004-10, Vol.104 (8), p.2247-2253

2004

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Abstract 4995: anti-ROR1 x anti-CD3 ADAPTIR™ molecule, ES425, redirects T-cell cytotoxicity and inhibits tumor growth in preclinical models of triple-negative breast cancer

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4995-4995

2016

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B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenström macroglobulinemia

Blood, 2006-04, Vol.107 (7), p.2882-2888

2006

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CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

Nature (London), 1992-04, Vol.356 (6370), p.607-609

1992

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A Role for B Cell-Activating Factor of the TNF Family in Chemically Induced Autoimmunity

The Journal of immunology (1950), 2005-11, Vol.175 (9), p.6163-6168

2005

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B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenström macroglobulinemia

Blood, 2006-04, Vol.107 (7), p.2882-2888

2006

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Abstract 280: Synergistic in vitro activity of MOR209/ES414 in combination with enzalutamide

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.280-280

2016

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Abstract LB-199: APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity with limited cytokine release, is well tolerated in repeat dose toxicology studies in cynomolgus macaques

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.LB-199-LB-199

2019

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Preliminary Results from a Phase 1 Study of APVO436, a Novel Anti-CD123 x Anti-CD3 Bispecific Molecule, in Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome

Blood, 2020-11, Vol.136 (Supplement 1), p.11-12

2020

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Abstract 1786: APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity, induces potent T-cell activation, proliferation and cytotoxicity with limited cytokine release

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1786-1786

2018

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Abstract B111: Characterization of APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity, in preclinical models of AML and nonhuman primates

Molecular cancer therapeutics, 2018-01, Vol.17 (1_Supplement), p.B111-B111

2018

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Abstract 597: Bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecules for redirected T-cell cytotoxicity in hematological malignancies

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.597-597

2017

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Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival

Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

Increased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation

Elevated Serum B-Lymphocyte Stimulator Levels in Patients With Familial Lymphoproliferative Disorders

MOR209/ES414, a Novel Bispecific Antibody Targeting PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

An APRIL to remember: novel TNF ligands as therapeutic targets

IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis

Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

TACI-Ig Neutralizes Molecules Critical for B Cell Development and Autoimmune Disease: Impaired B Cell Maturation in Mice Lacking BLyS

B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin

Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

The INNs and outs of antibody nonproprietary names

Abstract 4995: anti-ROR1 x anti-CD3 ADAPTIR™ molecule, ES425, redirects T-cell cytotoxicity and inhibits tumor growth in preclinical models of triple-negative breast cancer

B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenström macroglobulinemia

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

A Role for B Cell-Activating Factor of the TNF Family in Chemically Induced Autoimmunity

B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenström macroglobulinemia

Abstract 280: Synergistic in vitro activity of MOR209/ES414 in combination with enzalutamide

Abstract LB-199: APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity with limited cytokine release, is well tolerated in repeat dose toxicology studies in cynomolgus macaques

Preliminary Results from a Phase 1 Study of APVO436, a Novel Anti-CD123 x Anti-CD3 Bispecific Molecule, in Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome

Abstract 1786: APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity, induces potent T-cell activation, proliferation and cytotoxicity with limited cytokine release

Abstract B111: Characterization of APVO436, a bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecule for redirected T-cell cytotoxicity, in preclinical models of AML and nonhuman primates

Abstract 597: Bispecific anti-CD123 x anti-CD3 ADAPTIR™ molecules for redirected T-cell cytotoxicity in hematological malignancies

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