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A method for intuitively extracting macromolecular dynamics from structural disorder

Nature communications, 2021-09, Vol.12 (1), p.5493-5493, Article 5493

2021

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The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Genes & development, 2014-02, Vol.28 (4), p.305-316

2014

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Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense

Immunological reviews, 2016-11, Vol.274 (1), p.33-58

2016

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Modelling dynamics in protein crystal structures by ensemble refinement

eLife, 2012-12, Vol.1, p.e00311-e00311

2012

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Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Nature communications, 2019-01, Vol.10 (1), p.365-365, Article 365

2019

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Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

Nature structural & molecular biology, 2017-08, Vol.24 (8), p.643-651

2017

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Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

Science (American Association for the Advancement of Science), 2018-02, Vol.359 (6377), p.794-797

2018

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Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

Science (American Association for the Advancement of Science), 2014-03, Vol.343 (6176), p.1260-1263

2014

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Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography

Cell reports (Cambridge), 2016-04, Vol.15 (1), p.1-8

2016

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Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry

Nature communications, 2017-11, Vol.8 (1), p.1280-9, Article 1280

2017

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Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors

Nature communications, 2022-09, Vol.13 (1), p.5519-5519, Article 5519

2022

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Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode

The EMBO journal, 2016-05, Vol.35 (10), p.1133-1149

2016

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Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

Nature communications, 2018-10, Vol.9 (1), p.4337-9, Article 4337

2018

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Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D

Acta crystallographica. Section D, Biological crystallography., 2014-03, Vol.70 (3), p.733-743

2014

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Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Frontiers in immunology, 2019-09, Vol.10, p.2097-2097

2019

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Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

Cell reports (Cambridge), 2012-03, Vol.1 (3), p.200-207

2012

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Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1)

The Journal of biological chemistry, 2020-07, Vol.295 (28), p.9502-9512

2020

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Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

Nature immunology, 2009-07, Vol.10 (7), p.721-727

2009

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Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling

PloS one, 2013-12, Vol.8 (12), p.e83110-e83110

2013

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Structure of the translocator domain of a bacterial autotransporter

The EMBO journal, 2004-03, Vol.23 (6), p.1257-1266

2004

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Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

Cell reports (Cambridge), 2013-06, Vol.3 (6), p.1885-1892

2013

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Analysis of C3 Gene Variants in Patients With Idiopathic Recurrent Spontaneous Pregnancy Loss

Frontiers in immunology, 2018-08, Vol.9 (AUG), p.1813

2018

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Structural insights into the Slit-Robo complex

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (38), p.14923-14928

2007

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‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development

Nature immunology, 2019-11, Vol.20 (11), p.1409-1413

2019

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Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition

The Journal of biological chemistry, 2007-10, Vol.282 (40), p.29241-29247

2007

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A method for intuitively extracting macromolecular dynamics from structural disorder

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense

Modelling dynamics in protein crystal structures by ensemble refinement

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography

Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry

Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1)

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling

Structure of the translocator domain of a bacterial autotransporter

Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5

Analysis of C3 Gene Variants in Patients With Idiopathic Recurrent Spontaneous Pregnancy Loss

Structural insights into the Slit-Robo complex

‘Stealth’ corporate innovation: an emerging threat for therapeutic drug development

Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition

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