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Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

Journal of bone and mineral research, 2016-09, Vol.31 (9), p.1652-1665

2016

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Thoughts on "fitness for detention"

הרפואה, 2015-07, Vol.154 (7), p.464

Groppe, C

2015

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Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy

Expert opinion on drug discovery, 2019-12, Vol.14 (12), p.1237-1253

Groppe, Jay C.

2019

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Functional modeling of the ACVR1 (R206H) mutation in FOP

Clinical orthopaedics and related research, 2007-09, Vol.462, p.87-92

2007

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Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Biomolecules (Basel, Switzerland), 2023-07, Vol.13 (7), p.1129

2023

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Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN

PLoS genetics, 2009-11, Vol.5 (11), p.e1000747-e1000747

2009

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Pathogenic mechanisms of tooth agenesis linked to paired domain mutations in human PAX9

Human molecular genetics, 2009-08, Vol.18 (15), p.2863-2874

2009

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Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients

American journal of medical genetics. Part A, 2015-10, Vol.167A (10), p.2265-2271

2015

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Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3

Nature medicine, 2013-07, Vol.19 (7), p.809-810

2013

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Matrix metalloproteinase-9 deficiency confers resilience in fibrodysplasia ossificans progressiva in a man and mice

Journal of bone and mineral research, 2024-05, Vol.39 (4), p.382-398

2024

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Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole‐Exome Sequencing in a Patient with Delayed‐Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H‐Specific Human Cellular and Zebrafish Models

Journal of bone and mineral research, 2022-11, Vol.37 (11), p.2058-2076

2022

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Intricacies of BMP receptor assembly

Cytokine & growth factor reviews, 2009-10, Vol.20 (5), p.367-377

2009

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Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance

PloS one, 2012-04, Vol.7 (4), p.e35062

2012

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Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification

Bone (New York, N.Y.), 2018-07, Vol.112, p.71-89

2018

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An ACVR1 R375P pathogenic variant in two families with mild fibrodysplasia ossificans progressiva

American journal of medical genetics. Part A, 2022-03, Vol.188 (3), p.806-817

2022

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In vitro Analyses of the Dysregulated R206H ALK2 Kinase-FKBP12 Interaction Associated with Heterotopic Ossification in FOP

Cells, tissues, organs, 2011-08, Vol.194 (2-4), p.291-295

2011

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An ACVR1R375P pathogenic variant in two families with mild fibrodysplasia ossificans progressiva

American journal of medical genetics. Part A, 2022-03, Vol.188 (3), p.806-817

2022

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Structure and Dynamics of the Homodimeric Dynein Light Chain km23

Journal of molecular biology, 2005-09, Vol.352 (2), p.338-354

2005

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Expression, Purification, and Characterization of a Soluble Form of the First Extracellular Domain of the Human Type 1 Corticotropin Releasing Factor Receptor

The Journal of biological chemistry, 2001-08, Vol.276 (34), p.31528-31534

2001

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The TβR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding

Journal of molecular biology, 2011-09, Vol.412 (4), p.601-618

2011

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Assembly of TβRI:TβRII:TGFβ Ternary Complex in vitro with Receptor Extracellular Domains is Cooperative and Isoform-dependent

Journal of molecular biology, 2005-12, Vol.354 (5), p.1052-1068

2005

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Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds

Biochemical genetics, 2012-02, Vol.50 (1-2), p.12-18

2012

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Isolation of Full-Length RNA Templates for Reverse Transcription from Tissues Rich in RNase and Proteoglycans

Analytical biochemistry, 1993-05, Vol.210 (2), p.337-343

1993

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Molluscan Chymotrypsin-like Protease: Structure, Localization, and Substrate Specificity

Archives of biochemistry and biophysics, 1993-08, Vol.305 (1), p.159-169

1993

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Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1 R206H -Specific Human Cellular and Zebrafish Models

Journal of bone and mineral research, 2022-11, Vol.37 (11), p.2058

2022

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Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling

Thoughts on "fitness for detention"

Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy

Functional modeling of the ACVR1 (R206H) mutation in FOP

Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN

Pathogenic mechanisms of tooth agenesis linked to paired domain mutations in human PAX9

Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients

Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3

Matrix metalloproteinase-9 deficiency confers resilience in fibrodysplasia ossificans progressiva in a man and mice

Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole‐Exome Sequencing in a Patient with Delayed‐Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1R206H‐Specific Human Cellular and Zebrafish Models

Intricacies of BMP receptor assembly

Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance

Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification

An ACVR1 R375P pathogenic variant in two families with mild fibrodysplasia ossificans progressiva

In vitro Analyses of the Dysregulated R206H ALK2 Kinase-FKBP12 Interaction Associated with Heterotopic Ossification in FOP

An ACVR1R375P pathogenic variant in two families with mild fibrodysplasia ossificans progressiva

Structure and Dynamics of the Homodimeric Dynein Light Chain km23

Expression, Purification, and Characterization of a Soluble Form of the First Extracellular Domain of the Human Type 1 Corticotropin Releasing Factor Receptor

The TβR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding

Assembly of TβRI:TβRII:TGFβ Ternary Complex in vitro with Receptor Extracellular Domains is Cooperative and Isoform-dependent

Nucleotide Polymorphisms in the Canine Noggin Gene and Their Distribution Among Dog (Canis lupus familiaris) Breeds

Isolation of Full-Length RNA Templates for Reverse Transcription from Tissues Rich in RNase and Proteoglycans

Molluscan Chymotrypsin-like Protease: Structure, Localization, and Substrate Specificity

Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1 R206H -Specific Human Cellular and Zebrafish Models

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