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Cardiovascular drug discovery: a perspective from a research-based pharmaceutical company

Cold Spring Harbor perspectives in medicine, 2014-06, Vol.4 (6), p.a014092-a014092

2014

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Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Cell reports (Cambridge), 2014-11, Vol.9 (3), p.810-820

2014

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Target selection in drug discovery

Nature reviews. Drug discovery, 2003-01, Vol.2 (1), p.63-69

2003

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Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

Circulation (New York, N.Y.), 1999-01, Vol.99 (3), p.384-391

1999

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Long-term growth of lymphokine-activated killer (LAK) cells: role of anti-CD3, beta-IL 1, interferon-gamma and -beta

The Journal of immunology (1950), 1987-04, Vol.138 (8), p.2728

1987

Volltextzugriff (PDF)

The macrophage-activating tetrapeptide tuftsin induces nitric oxide synthesis and stimulates murine macrophages to kill Leishmania parasites in vitro

Infection and Immunity, 1994-06, Vol.62 (6), p.2649-2652

1994

Volltextzugriff (PDF)

Effect of partially modified retro‐inverso analogues derived from C‐reactive protein on the induction of nitric oxide synthesis in peritoneal macrophages

British journal of pharmacology, 1997-04, Vol.120 (7), p.1383-1389

1997

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Delivery of saporin to human B-cell lymphoma using bispecific antibody : targeting via CD22 but not CD19, CD37, or immunoglobulin results in efficient killing

Cancer research (Chicago, Ill.), 1993-07, Vol.53 (13), p.3015-3021

1993

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A comparison of anti‐lymphocyte immunotoxins containing different ribosome‐inactivating proteins and antibodies

Clinical and experimental immunology, 1992-09, Vol.89 (3), p.341-346

1992

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Different cytotoxic activity and intracellular fate of an anti-CD5-momordin immunotoxin in normal compared to tumour cells

Cancer Immunology Immunotherapy, 1995-07, Vol.40 (4), p.213-218

1995

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In vitro and in vivo properties of an anti-CD5 momordin immunotoxin on normal and neoplastic T lymphocytes

Cancer Immunology Immunotherapy, 1993-09, Vol.36 (5), p.346-350

1993

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Cochaperonins Are Histone-Binding Proteins

Biochemical and biophysical research communications, 1995-01, Vol.206 (1), p.260-265

1995

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Initial experience in treating human lymphoma with a combination of bispecific antibody and saporin

International journal of cancer, 1992, Vol.7 (sup. 7), p.73-77

1992

Volltextzugriff (PDF)

Expression and Activity of Pre-dianthin 30 and Dianthin 30

Biochemical and biophysical research communications, 1993-05, Vol.192 (3), p.1230-1237

1993

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Thymopentin reduces the susceptibility of aged mice to cutaneous leishmaniasis by modulating CD4 T-cell subsets

Immunology, 1992-07, Vol.76 (3), p.362-366

1992

Volltextzugriff (PDF)

New Antianginal Nitro Esters with Reduced Hypotensive Activity. Synthesis and Pharmacological Evaluation of 3-[(Nitrooxy)alkyl]-2H-1,3-benzoxazin-4(3H)-ones

Journal of medicinal chemistry, 1995-01, Vol.38 (1), p.130-136

1995

Volltextzugriff (PDF)

Arthritogenic potential of the 65 kDa stress protein--an experimental model

Annals of the rheumatic diseases, 1994-03, Vol.53 (3), p.197-201

1994

Volltextzugriff (PDF)

Stepwise activation of T cells. Role of the calcium ionophore A23187

The Journal of immunology (1950), 1987-12, Vol.139 (12), p.3930

1987

Volltextzugriff (PDF)

Heterologous expression, purification, activity and conformational studies of different forms of dianthin 30

Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity, 1995, Vol.1 (2), p.61

1995

Volltextzugriff (PDF)

Cytotoxic T Lymphocytes: Blocked Differentiation at the ‘Poised’ Stage

Scandinavian journal of immunology, 1987-04, Vol.25 (4), p.383-391

1987

Volltextzugriff (PDF)

Anti-CD2 monoclonal antibodies and calcium ionophore A23187 modulate lytic activity in CD4+ and CD8+ alloreactive clones

The Journal of immunology (1950), 1988-05, Vol.140 (9), p.2876

1988

Volltextzugriff (PDF)

Fibroplastic endomyocarditis with eosinophilia: presentation of a fatal case and diagnostic considerations on eosinophilic leukemia

Haematologica (Roma), 1984-03, Vol.69 (2), p.218

1984

Volltextzugriff (PDF)

Role of CD2 and IL 1 beta in T cell responsiveness to IL 2

The Journal of immunology (1950), 1987-04, Vol.138 (7), p.2155

1987

Volltextzugriff (PDF)

Minimal signals and step-wise maturation of cytotoxic T cells

Transplantation proceedings, 1988-04, Vol.20 (2), p.296-297

1988

Volltextzugriff (PDF)

In vitro effects of adenosine induced supernatants on human T lymphocyte functions

Haematologica (Roma), 1987-05, Vol.72 (3), p.215

1987

Volltextzugriff (PDF)

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Cardiovascular drug discovery: a perspective from a research-based pharmaceutical company

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

Target selection in drug discovery

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

Long-term growth of lymphokine-activated killer (LAK) cells: role of anti-CD3, beta-IL 1, interferon-gamma and -beta

The macrophage-activating tetrapeptide tuftsin induces nitric oxide synthesis and stimulates murine macrophages to kill Leishmania parasites in vitro

Effect of partially modified retro‐inverso analogues derived from C‐reactive protein on the induction of nitric oxide synthesis in peritoneal macrophages

Delivery of saporin to human B-cell lymphoma using bispecific antibody : targeting via CD22 but not CD19, CD37, or immunoglobulin results in efficient killing

A comparison of anti‐lymphocyte immunotoxins containing different ribosome‐inactivating proteins and antibodies

Different cytotoxic activity and intracellular fate of an anti-CD5-momordin immunotoxin in normal compared to tumour cells

In vitro and in vivo properties of an anti-CD5 momordin immunotoxin on normal and neoplastic T lymphocytes

Cochaperonins Are Histone-Binding Proteins

Initial experience in treating human lymphoma with a combination of bispecific antibody and saporin

Expression and Activity of Pre-dianthin 30 and Dianthin 30

Thymopentin reduces the susceptibility of aged mice to cutaneous leishmaniasis by modulating CD4 T-cell subsets

New Antianginal Nitro Esters with Reduced Hypotensive Activity. Synthesis and Pharmacological Evaluation of 3-[(Nitrooxy)alkyl]-2H-1,3-benzoxazin-4(3H)-ones

Arthritogenic potential of the 65 kDa stress protein--an experimental model

Stepwise activation of T cells. Role of the calcium ionophore A23187

Heterologous expression, purification, activity and conformational studies of different forms of dianthin 30

Cytotoxic T Lymphocytes: Blocked Differentiation at the ‘Poised’ Stage

Anti-CD2 monoclonal antibodies and calcium ionophore A23187 modulate lytic activity in CD4+ and CD8+ alloreactive clones

Fibroplastic endomyocarditis with eosinophilia: presentation of a fatal case and diagnostic considerations on eosinophilic leukemia

Role of CD2 and IL 1 beta in T cell responsiveness to IL 2

Minimal signals and step-wise maturation of cytotoxic T cells

In vitro effects of adenosine induced supernatants on human T lymphocyte functions

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